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Michigan vs USC Prediction 10/11/2025 Today’s College Football Picks
Pick details
Michigan (4-1) vs USC (4-1)
October 11, 2025 at 07:30 PM EDT
The Line: Betting Odds: USC -2.5 — Over/Under: +57.5
The Michigan Wolverines and USC Trojans meet Saturday in college football action at Los Angeles Memorial Coliseum. Here’s a Michigan vs USC Prediction. This article will include a Michigan vs USC Pick.
The Michigan Wolverines beat Wisconsin and Nebraska, and they play Washington next. Michigan has won 7 of its last 8 games. Bryce Underwood is completing 59.2 percent of his passes for 1,003 yards, 3 touchdowns, and 1 interception. Donaven McCulley and Semaj Morgan have combined for 496 receiving yards and 2 touchdowns, while Marlin Klein has 11 receptions.
The Michigan Wolverines ground game is averaging 237.8 yards per contest, and Justice Haynes leads the way with 654 yards and 8 touchdowns. Defensively, Michigan is allowing 16.2 points and 283.8 yards per game. Ernest Hausmann leads the Michigan Wolverines with 31 tackles, Jaishawn Barham has 3 sacks and Cole Sullivan has 2 interceptions.
The USC Trojans beat Michigan State, lost to Illinois and play Notre Dame next. The USC Trojans have won 7 of their last 9 games. Jayden Maiava is completing 70.5 percent of his passes for 1,587 yards, 11 touchdowns and 1 interception. Makai Lemon and Jacobi Lane have combined for 867 receiving yards and 6 touchdowns, while Lake McRee has 12 receptions.
The USC Trojans ground game is averaging 227 yards per contest, and Waymond Jordan leads the way with 537 yards and 5 touchdowns. Defensively, USC is allowing 23 points and 359.4 yards per game. Eric Gentry leads the USC Trojans with 35 tackles, Braylan Shelby has 3.5 sacks and Bishop Fitzgerald has 3 interceptions.
USC is getting a lot of love because it’s at home, and it doesn’t hurt to be led by one of the best offenses in the country. However, we’re getting points with the better team overall, and there’s usually value in this business when you can find spots like this. Michigan is the more proven team up to this point with notable wins, and its defense is far more trustworthy. USC can’t stop the pass at all, so a young potential star QB in Underwood will have his chances to make plays through the air. Should be a fun one, but I want the points with the Wolverines.
Michigan Wolverines Betting Preview
The Michigan Wolverines beat Wisconsin and Nebraska, and they play Washington next. Michigan has won 7 of its last 8 games. Bryce Underwood is completing 59.2 percent of his passes for 1,003 yards, 3 touchdowns, and 1 interception. Donaven McCulley and Semaj Morgan have combined for 496 receiving yards and 2 touchdowns, while Marlin Klein has 11 receptions.
The Michigan Wolverines ground game is averaging 237.8 yards per contest, and Justice Haynes leads the way with 654 yards and 8 touchdowns. Defensively, Michigan is allowing 16.2 points and 283.8 yards per game. Ernest Hausmann leads the Michigan Wolverines with 31 tackles, Jaishawn Barham has 3 sacks and Cole Sullivan has 2 interceptions.
USC Trojans Betting Preview
The USC Trojans beat Michigan State, lost to Illinois and play Notre Dame next. The USC Trojans have won 7 of their last 9 games. Jayden Maiava is completing 70.5 percent of his passes for 1,587 yards, 11 touchdowns and 1 interception. Makai Lemon and Jacobi Lane have combined for 867 receiving yards and 6 touchdowns, while Lake McRee has 12 receptions.
The USC Trojans ground game is averaging 227 yards per contest, and Waymond Jordan leads the way with 537 yards and 5 touchdowns. Defensively, USC is allowing 23 points and 359.4 yards per game. Eric Gentry leads the USC Trojans with 35 tackles, Braylan Shelby has 3.5 sacks and Bishop Fitzgerald has 3 interceptions.
Why the USC Trojans will win
- The favorite has won each of USC’s last nine games at United Airlines Field at the Los Angeles Memorial Coliseum.
- USC has covered the spread in seven of its last eight games as a favorite in California.
- The team ranked 15th in the AP Poll has failed to cover the spread in three of its last four games.
- USC has won the first half in three of its last four games against conference opponents.
- USC has won the first quarter in three of its last four home games against conference opponents.
Why the Michigan Wolverines will win
- Michigan has won 39 of its last 40 games against non-AP-ranked teams.
- USC has lost each of its last five games as a favorite against AP-ranked teams.
- USC has failed to cover the spread in each of its last five games as a favorite against AP-ranked teams.
- Michigan has covered the spread in four of its last five games against conference opponents.
- Michigan has won the first half in 32 of its last 41 games against conference opponents.
Total Points Facts
- Each of USC’s last nine games as a favorite against AP-ranked teams have gone OVER the total points line.
- Each of Michigan’s last seven road games against non-AP-ranked teams have gone OVER the total points line.
USC Trojans Player Prop Facts
- Heading into Week 7, Makai Lemon ranks 2nd amongst FBS players for receiving yards (589) this season.
Michigan Wolverines Player Prop Facts
- Heading into Week 7, Justice Haynes leads the Big Ten Conference for rushing yards (654) this season.
Matchup/League Facts
- USC ranks T1st among FBS teams for H2 points per game this season (23.6).
- USC ranks 2nd among FBS teams for yards per game this season (565.0).
- Michigan ranks 135th among FBS teams for 4th down conversion percentage this season (20.0).
- Michigan ranks 7th among FBS teams for rushing yards allowed per game this season (77.4).
Michigan vs USC Prediction
USC is getting a lot of love because it’s at home, and it doesn’t hurt to be led by one of the best offenses in the country. However, we’re getting points with the better team overall, and there’s usually value in this business when you can find spots like this. Michigan is the more proven team up to this point with notable wins, and its defense is far more trustworthy. USC can’t stop the pass at all, so a young potential star QB in Underwood will have his chances to make plays through the air. Should be a fun one, but I want the points with the Wolverines.
