Nov 1, 2025; Ann Arbor, Michigan, USA;  Michigan Wolverines running back Bryson Kuzdzal (24) rushes in the second half against the Purdue Boilermakers at Michigan Stadium. Mandatory Credit: Rick Osentoski-Imagn Images
Rick Osentoski-Imagn Images

Michigan vs Northwestern Prediction 11/15/2025 Today’s College Football Picks

Pick details

MATCHUP Michigan Wolverines Northwestern Wildcats
Team Records 7-2 5-4
Spread -12.5 -108 +12.5 -112
Moneyline -535 +400
Total Over 41.5 (-105) Under 41.5 (-115)
Where Wrigley Field, Chicago, IL
When Saturday, November 15, 2025
Time 12:00 PM EST
TV FOX

In this article, we will formulate a Michigan vs Northwestern Prediction for this College Football Week 12 game on Saturday, November 15th. Let’s take a look at the prediction for this College Football matchup.

Northwestern Wildcats Preview

Northwestern has a 5-4 record this season and is sitting 7th in the Big Ten. They are 5-3-1 ATS, 3-6 in Over/Under and have a 4-1 home record and a 1-3 away record. Northwestern is coming off a 17-38 road loss against USC and will face Minnesota next.

Offensively, Northwestern averages 21.9 points per game, ranking 108th in the nation, while defensively, they allow 19.1 points per game, which is 22nd. Northwestern averages 351.3 total yards per game (169.9 passing and 181.4 rushing), while allowing 323.9 total yards per game (142.8 rushing and 181.1 passing).

Preston Stone leads Northwestern with 1,522 passing yards with 59.3% completed passes and 14 touchdowns. Joseph Himon II leads the team in rushing yards with 397, while Griffin Wilde has a team-high 43 receptions for 598 receiving yards. Defensively, Robert Fitzgerald has a team-high 77 total tackles (49 of them solo), while Aidan Hubbard leads the team in sacks, with 3.5, and Ore Adeyi has a team-high one interception.

Michigan Wolverines Preview

Michigan has a 7-2 record this season and is sitting 5th in the Big Ten. They are 3-6 ATS, 4-5 in Over/Under and have a 5-0 home record and a 2-2 away record. Michigan is coming off a 21-16 home win against Purdue and will face Maryland next.

Offensively, Michigan averages 28.1 points per game, ranking 69th in the nation, while defensively, they allow 17.2 points per game, which is 14th. Michigan averages 409.4 total yards per game (185.7 passing and 223.8 rushing), while allowing 304.0 total yards per game (100.2 rushing and 203.8 passing).

Bryce Underwood leads Michigan with 1,671 passing yards with 60.9% completed passes and 7 touchdowns. Justice Haynes leads the team in rushing yards with 857, while Donaven McCulley has a team-high 26 receptions for 383 receiving yards. Defensively, Ernest Hausmann has a team-high 66 total tackles (42 of them solo), while Derrick Moore leads the team in sacks, with 8.5, and Cole Sullivan has a team-high 3 interceptions.

Michigan Wolverines @ Northwestern Wildcats Betting Trends: Week 12


Why the Northwestern Wildcats will win

  • The home team has won five of Northwestern’s last six games.
  • The home team has covered the spread in each of the last five games between Michigan and Northwestern.
  • Michigan has failed to cover the spread in each of its last four games in Illinois.
  • Northwestern has won the first quarter in three of its last four home games against conference opponents.

Why the Michigan Wolverines will win

  • Northwestern has lost each of its last 13 games against AP-ranked teams.
  • Michigan has won 42 of its last 44 games against non-AP-ranked teams.
  • Michigan has covered the spread in seven of its last eight road games in November.
  • Northwestern has failed to cover the spread in each of its last five games against teams from Michigan.
  • Michigan has won the first quarter in each of its last three games against conference opponents.
  • Northwestern has lost the first half in seven of its last nine games against conference opponents.

Total Points Facts

  • Eight of Michigan’s last nine road games against non-AP-ranked teams have gone OVER the total points line.
  • Five of Northwestern’s last six home games against conference opponents have gone UNDER the total points line.

Northwestern Wildcats Player Prop Facts

  • Heading into Week 12, Joseph Himon II has the most rushing attempts without a rushing touchdown this season (81).

Michigan Wolverines Player Prop Facts

  • Heading into Week 12, Derrick Moore ranks T8th amongst FBS players for sacks (8.5) this season.

Matchup/League Facts

  • Northwestern ranks 13th among FBS teams for time of possession per game this season (32:43).
  • Northwestern ranks 119th among FBS teams for passing yards per game this season (169.9).
  • Michigan ranks 136th among FBS teams for 4th down conversion percentage this season (20.0).
  • Michigan ranks T9th among FBS teams for H2 opponent points per game this season (7.7).

Michigan vs Northwestern Prediction

In this Michigan vs Northwestern Prediction, Michigan is coming as -11.5-point road favorites, with the total set at 41 points. Michigan has the better overall record and has been in very good form lately, with a 6-1 record in its last 7 games. They have the 14th-best defense in the country and are up against Northwestern, who also have an efficient defensive line, ranking 22nd in the country and both teams allow just 36.3 points per game combined. I expect a tight low-scoring affair, so take the under 41 in this one.

Nikos Lagouretos's Pick: Over 41

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