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Michigan vs Michigan State Prediction 10/25/2025 Today’s College Football Picks

Pick details

Michigan (5-2) vs Michigan State (3-4)

October 25, 2025 at 07:30 PM EDT

The Line: Betting Odds: Michigan State +13.5 — Over/Under: +48.5

(Get latest betting odds)

The Michigan Wolverines and the Michigan State Spartans meet Saturday in college football action from Spartan Stadium. Here’s a Michigan vs Michigan State prediction. We will look at this from a betting perspective and determine the best Michigan vs Michigan State pick. We will examine:

The Michigan Wolverines recent form and player performance

The Michigan State Spartans recent form and player performance

Recent betting trends and streaks involving the Michigan Wolverines

Recent betting trends and streaks involving the Michigan State Spartans

Recent betting trends in games played between Michigan and Michigan State

A summary that ties it all together and produces a favorable betting outcome for the Michigan vs Michigan State game

Michigan Wolverines Betting Preview


The Wolverines didn’t have too much trouble in their opener this year, dispatching New Mexico by 17 points. Game two was a loss to Oklahoma, but Michigan would then rattle off wins over Central Michigan, Nebraska and Wisconsin in the next three. Game six was another loss though, this time versus USC. In the road defeat at the hands of the Trojans, Michigan gave up 489 yards on defense alongside 224 rush yards, 7.2 yards per play and 6-of-12 on third downs. The Wolverines’ offense notched just 2-of-9 on third downs themselves and had a couple of interceptions in the defeat.

In Saturday’s matchup with Washington, Michigan had a 7-7 tie by halftime. The Wolverines got going on a 17-0 run after that though, winning 24-7 in the end at home. QB Bryce Underwood was 21-of-27 for 230 yards and two scores, while Jordan Marshall led the rush on 25 totes for 133 yards and a TD. Zach Marshall was the leading receiver with five catches for 72 yards and a touchdown of his own in the winning effort.

Michigan State Spartans Betting Preview


Over on the Spartans’ side, they started out quite well themselves with a win over Western Michigan in the opener this year. After a two-point escape at home versus Boston College, Michigan State beat Youngstown State. Next came a losing streak however, as Michigan State would fall to USC, Nebraska and UCLA in the ensuing trio. In the Bruins loss, the Spartans could only gain 253 total yards (87 rushing) with 4.2 yards per play and 14 first downs. The defense gave up 238 rushing yards on the other side and couldn’t generate a takeaway.

Matched up against Indiana over the weekend, the Spartans gave up points in all four quarters—including 14 in both the second and third—along the way to a 38-13 road defeat. QB Aidan Chiles was 27-of-33 for 243 yards and one touchdown, while also leading the rush with eight carries for 48 yards in the loss. Nick Marsh was the team’s leading receiver with seven catches for 64 yards along the way.

Michigan Wolverines @ Michigan State Spartans Betting Trends: Week 9

Michigan State Spartans Player Prop Facts

 
 
Heading into Week 9, Aidan Chiles leads Michigan State for touchdowns (5) this season.

Michigan Wolverines Player Prop Facts

 
 
Heading into Week 9, Justice Haynes ranks T9th amongst FBS players for rushing yards (705) this season.

Matchup/League Facts

 
 
Michigan State ranks T114th among FBS teams for H2 opponent points per game this season (14.6).
Michigan State ranks T113th among FBS teams for H1 opponent points per game this season (16.3).
Michigan ranks 12th among FBS teams for H2 opponent points per game this season (6.7).
Michigan ranks 15th among FBS teams for rushing yards allowed per game this season (93.0).

Michigan vs Michigan State Prediction


I’ll stay with Michigan. The Wolverines contained a good Washington team well last weekend, giving up just 249 yards, 40 rushing yards, 4.5 yards per play and 14 first downs alongside three interceptions. The offense took a while to get going but it was a nice bounce-back effort overall after scoring just 13 points in a road blowout versus USC in their previous outing.

As for Michigan State, they ran into the buzzsaw of a very good Indiana team last weekend. The Spartans generated a respectable 293 pass yards and 5.9 yards per play, but the 19 first downs and 5-of-14 on third-down tries weren’t enough to keep pace. The Spartans defense gave up 464 yards (332 passing), 8.3 yards per play and 24 first downs on the other side. That makes four straight losses for Michigan State, and they’ve been outscored 38-13 in each of the last two. I don’t see them keeping up with the Wolverines in any meaningful capacity.

Andrew Jett's Pick: Michigan Wolverines -13.5

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