Michigan State vs Nebraska Prediction 10/4/2025 Today’s College Football Picks

The Michigan State Spartans and the Nebraska Cornhuskers meet in week 6 college football action from the Memorial Stadium on Saturday. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Michigan State Spartans vs. Nebraska Cornhuskers prediction.

Michigan State Spartans Recap

The Michigan State Spartans come into this game looking to rebound from a 45-31 loss at the hands of USC prior to their bye week last week, falling to 3-1 on the year as a result. After this game, Michigan State will head home for a matchup against UCLA. 

Spartans Looking To Regroup After First L

Aidan Chiles has thrown for 868 yards, 9 touchdowns and an interception on 68.6% passing while also rushing for 154 yards and 2 TDs. Makhi Frazier has 267 rushing yards with 2 touchdowns to lead Michigan State while Brandon Tullis has 128 rushing yards with 2 TDs. Omari Kelly leads Michigan State in receiving with 21 catches for 317 yards while Nick Marsh has 18 catches for 222 yards and 3 touchdowns so far this season. Chrishon McCray’s also added 128 receiving yards and Michael Masunas also has a pair of receiving TDs as well for Michigan State so far this season. On defense, Jordan Hall leads the Spartans with 30 total tackles including a team-high 16 solo tackles and a pair of sacks while Wayne Matthews III has 26 total tackles and Anelu Lafaele has a pair of sacks as well this season.

Nebraska Cornhuskers Recap

The Nebraska Cornhuskers come into this game looking to bounce back thanks to a 30-27 loss at the hands of Michigan in their last game, sitting at 3-1 this season as a result prior to last week’s bye week. After this game, Nebraska will head on the road for a game against the Maryland Terrapins.

Cornhuskers Looking For Rebound Performance

Dylan Raiola has thrown for 1,137 yards, 11 touchdowns and an interception on 75.6% passing while Emmett Johnson leads the Cornhuskers in rushing with 391 yards on the ground along with 4 touchdowns and Kwinten Ives has 119 rushing yards and 2 TDs as well this season. Jacory Barney Jr. has a team-high 21 catches for 301 yards and 3 touchdowns while Dane Key’s added 16 catches for 226 yards and 3 TDs as well this season. Three more Cornhuskers each have 100+ receiving yards as well on the year for Nebraska. On defense, three tacklers are tied for the team lead with 17 total tackles while Dasan McCullough has a team-high 2 sacks so far this season.

Michigan State Spartans @ Nebraska Cornhuskers Betting Trends: Week 6

Why the Nebraska Cornhuskers will win

• Michigan State has lost each of its last six road games in October.
• The favorite has won each of Nebraska’s last eight games.
• Michigan State has failed to cover the spread in each of its last seven games against non-AP-ranked teams.
• The favorite has covered the spread in each of Nebraska’s last four games at Memorial Stadium (Lincoln).
• Michigan State has lost the first half in each of its last four road games against conference opponents.

Why the Michigan State Spartans will win

• Nebraska has lost each of its last six games against teams from Michigan.
• Michigan State has won four of its last five games against non-AP-ranked teams.
• The road team has covered the spread in each of Michigan State’s last six games.
• Nebraska has failed to cover the spread in each of its last six games against teams from Michigan.

Total Points Facts

• Each of Nebraska’s last five games at Memorial Stadium (Lincoln) have gone OVER the total points line.
• Each of Michigan State’s last five games as an underdog have gone OVER the total points line.

Nebraska Cornhuskers Player Prop Facts

• Heading into Week 6, Dylan Raiola ranks T3rd in the league for TD:INT ratio (11.00) this season.

Michigan State Spartans Player Prop Facts

• Heading into Week 6, Ryan Eckley ranks 1st amongst qualified players for gross average yards per punt (53.0) this season.

Matchup/League Facts

• Nebraska ranks 1st among FBS teams for Q2 points per game this season (18.8).
• Nebraska ranks 1st among FBS teams for passing yards allowed per game this season (75.8).
• Michigan State has recorded the equal-most home wins by a margin of five points or less of any FBS team this season (1).
• Michigan State has recorded the equal-most home wins by a margin of three points or less of any FBS team this season (1).

Michigan State Spartans vs. Nebraska Cornhuskers Prediction

I’m going to lean towards Nebraska here. I think what we’ve seen so far is Nebraska’s blown out two subpar teams and the two teams on their level, Nebraska won against Cincinnati and lost to Michigan, both by 3 points. That being said, I just don’t think Michigan State has the talent to hang with Nebraska here as I think the Cornhuskers are just the better team across the board here and should have no problems winning this game by a couple of scores, something like 31-17. Give me Nebraska in this one.