Michigan State vs Iowa Prediction 11/22/2025 Today’s College Football Picks

The Michigan State Spartans and the Iowa Hawkeyes meet in week 13 college football action from Kinnick Stadium on Saturday. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Michigan State Spartans vs. Iowa Hawkeyes prediction.

Michigan State Spartans Recap

The Michigan State Spartans come into this game looking to bounce back from a 28-10 loss at the hands of Penn State last time out to sit at 3-7 this season. After this game, Michigan State will head home for a game against Maryland to close out the regular season.

Spartans Drop 7 In A Row

Aidan Chiles has thrown for 1,392 yards, 10 touchdowns and 3 interceptions on 63.1% passing while Alessio Milivojevic has thrown for 720 yards, 4 touchdowns and an interception on 64.1% passing. Makhi Frazier has a team-high 520 rushing yards and 2 TDs while Elijah Tau-Tolliver has 298 rushing yards and 2 TDs. Nick Marsh has a team-high 48 catches for 559 yards and 5 TDs to lead MSU in receiving while Omari Kelly has 41 grabs for 544 yards and a TD. Jordan Hall leads the Spartans’s defense with 74 total tackles while Michigan State’s defense as a whole has combined for 17 sacks and 3 interceptions so far this season. 

Iowa Hawkeyes Recap

The Iowa Hawkeyes come into this game looking to bounce back from a 26-21 loss at the hands of USC last time out to sit at 6-4 this season. After this game, Iowa will head on the road to close out the regular season against Nebraska.

Hawkeyes Drop Back-To-Back Games

Mark Gronowski has thrown for 1,216 yards, 6 touchdowns and 5 interceptions on 63.9% passing while also rushing for 370 yards and 13 touchdowns this season. Kamari Moulton leads Iowa with 612 rushing yards along with 2 touchdowns while Xavier Williams has 258 rushing yards and 3 TDs and Jaziun Patterson has 263 rushing yards. Jacob Gill leads the Hawkeyes in receiving with 18 grabs for 237 yards while Sam Phillips has 216 receiving yards this season. On defense, Karson Sharar leads Iowa with 63 total tackles while Max Llewellyn has a team-high 6 sacks and Ethan Hurkett and Aaron Graves each have 5 sacks. As a unit, Iowa’s defense has combined for 19 sacks and 10 interceptions this season. 

Michigan State Spartans @ Iowa Hawkeyes Betting Trends: Week 13

Why the Iowa Hawkeyes will win

• Iowa has won each of its last nine home games against non-AP-ranked teams.
• Michigan State has lost each of its last eight road games.
• Iowa has covered the spread in seven of its last eight games.
• Michigan State has failed to cover the spread in six of its last seven games in November.
• Michigan State has lost the first half in each of its last eight games against conference opponents.

Why the Michigan State Spartans will win

• The road team has covered the spread in 11 of Michigan State’s last 12 games.
• Iowa has failed to cover the spread in 12 of its last 16 November games as a home favorite against non-AP-ranked teams.

Total Points Facts

• Each of Iowa’s last four games as a favorite against teams from Michigan have gone OVER the total points line.
• Six of Michigan State’s last seven road games in November have gone UNDER the total points line.

Iowa Hawkeyes Player Prop Facts

• Heading into Week 13, Kaden Wetjen is the only player in the FBS to have both a punt and kick return touchdown this season.

Michigan State Spartans Player Prop Facts

• Heading into Week 13, Ryan Eckley ranks 1st amongst qualified players for gross average yards per punt (49.6) this season.

Matchup/League Facts

• Iowa ranks 1st among FBS teams for 4th down conversion percentage against this season (20.0).
• Iowa ranks T3rd among FBS teams for H2 opponent points per game this season (5.5).
• Michigan State ranks T125th among FBS teams for interceptions this season (3).
• Michigan State ranks 115th among FBS teams for points allowed per game this season (31.1).

Michigan State Spartans vs. Iowa Hawkeyes Prediction

I’m on Michigan State and the points here. This is the first time we’re seeing Iowa as a big favorite in conference play, and admittedly their conference losses have come to three of the best in the Big Ten. However, Michigan State needs to win to clinch a bowl game, and I’m not saying they win, but I think Sparty puts out an inspired effort to at least keep their hopes alive in this one. I’ll go with Michigan State and the points here.

Chris Ruffolo's Pick: Michigan State +16.5