Louisville vs Virginia Tech Prediction 11/1/2025 Today’s College Football Picks

The Louisville Cardinals and the Virginia Tech Hokies meet in week 10 college football action from Lane Stadium on Saturday. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Louisville Cardinals vs. Virginia Tech Hokies prediction.

Louisville Cardinals Recap

The Louisville Cardinals come into this game looking to build on a 38-24 win over Boston College last time out to improve to 6-1 this season. After this game, Louisville will head home for a game against Cal.

Cardinals Win Back-To-Back Games

Miller Moss leads Louisville in passing with 1,793 yards, 10 touchdowns and 5 interceptions on 65% passing while Isaac Brown has a team-high 652 rushing yards and 4 touchdowns. Chris Bell leads Louisville’s receiving group with 48 grabs for 687 yards and 6 touchdowns while Caullin Lacy has 38 catches for 369 yards and a TD. On defense, TJ Quinn has a team-high 49 total tackles while Antonio Watts has a team-high 3 INTs and Clev Lubin and Wesley Bailey each have 4 sacks. As a unit, Louisville’s defense has combined for 16 sacks and 12 interceptions so far this season.

Virginia Tech Hokies Recap

The Virginia Tech Hokies come into this game looking to add on to their 42-34 win over Cal in their last game to sit at 3-5 this season. After this game, Virginia Tech will head out for a bye before going on the road to take on Florida State.

Hokies Snap Two-Game Slide

Kyron Drones has thrown for 1,516 yards, 14 touchdowns and 6 interceptions on 59.7% passing while also rushing for 414 yards and 7 TDs. Marcellous Hawkins has 531 rushing yards to lead the Hokies while Terion Stewart has 373 rushing yards. Ayden Greene leads the Hokies with 23 catches for 365 yards and 2 TDs while Donavon Greene has 274 receiving yards as well on the year. Kaleb Spencer leads Virginia Tech’s defense with 42 total tackles while Kemari Copeland has a team-high 4 sacks. As a unit, Virginia Tech’s defense has combined for 17 sacks and 3 interceptions.

Louisville Cardinals @ Virginia Tech Hokies Betting Trends: Week 10

Why the Virginia Tech Hokies will win

• Virginia Tech has won seven of its last nine games after coming off overtime.
• The underdog has covered the spread in seven of Louisville’s last eight games.
• Louisville has failed to cover the spread in each of its last four games against teams from Virginia.
• Virginia Tech has won the first quarter in each of its last three home games against conference opponents.

Why the Louisville Cardinals will win

• Louisville has won each of its last eight games against non-AP-ranked teams.
• Virginia Tech has lost eight of its last nine games against AP-ranked teams.
• Virginia Tech has failed to cover the spread in each of its last four November games against AP-ranked teams.
• Louisville has covered the spread in four of its last five November games as a road favorite.
• Virginia Tech has lost the first half in each of its last three games against conference opponents.

Total Points Facts

• Each of Virginia Tech’s last eight November games as an underdog against AP-ranked teams have gone UNDER the total points line.
• Eight of Louisville’s last nine games as a favorite against teams from Virginia have gone UNDER the total points line.

Virginia Tech Hokies Player Prop Facts

• Heading into Week 10, Cameron Seldon ranks 5th amongst qualified players for catch rate (95.0%) this season.

Louisville Cardinals Player Prop Facts

• Heading into Week 10, Isaac Brown ranks 1st amongst qualified players for Yards Per Carry (8.7) this season.

Matchup/League Facts

• Virginia Tech ranks T134th among FBS teams for red zone percentage against this season (100.0).
• Virginia Tech ranks T119th among FBS teams for Q4 opponent points per game this season (8.6).
• Louisville ranks T4th among FBS teams for interceptions this season (12).
• Louisville ranks T6th among FBS teams for 1st downs against this season (106).

Louisville Cardinals vs. Virginia Tech Hokies Prediction

I’m on Louisville here. I get that it’s a Saturday game here in Blacksburg, but the problem for Virginia Tech is just that I don’t trust this team offensively to sustain the success they had against Cal and go score for score against a superior Louisville offense. The Cardinals are just the better team by a fair margin and I look for them to get the W rather comfortably here. Give me Louisville.