Sep 13, 2025; Blacksburg, Virginia, USA;  Virginia Tech Hokies safety Tyson Flowers (11) tackles Old Dominion Monarchs quarterback Colton Joseph (1) during the third quarter at Lane Stadium. Mandatory Credit: Brian Bishop-Imagn Images

Liberty vs Old Dominion Prediction 9/27/2025 Today’s College Football Picks

Pick details

Liberty (1-3) vs Old Dominion (2-1)

September 27, 2025 at 06:00 PM EDT

The Line: Betting Odds: Old Dominion -16 — Over/Under: +51.5

(Get latest betting odds)

In this article we will formulate a Liberty vs Old Dominion prediction for this College Football game on Saturday, September 27th at S.B. Ballard Stadium in Norfolk, Virginia. Let’s take a look at the prediction for this week 5 matchup. 

Liberty Flames Betting Preview

The Liberty Flames are 1-3 this year after they lost to James Madison by a score of 31-13 last week. Liberty was tied at three after the first quarter and tied at 10 at the half, but they only managed three points in the second half in the loss. The Flames were out gained by a total of 440-233, went 3-14 on third downs, and won the turnover battle by a margin of 1-0 in the game. Ethan Vasko went 4-10 for 37 yards, while also rushing for 52 yards and one touchdown on 11 carries. Evan Dickens rushed 17 times for 67 yards, while Jamari Person caught two passes for 29 yards in the game. The Liberty defense recorded zero sacks and just two tackles for loss in the defeat. 

Liberty started the season with a 28-7 win over Maine, but they lost to Jacksonville State by a score of 34-24 and Bowling Green by a score of 23-13. The Flames are averaging 19.5 points per game with 200.3 passing yards and 172.3 rushing yards per game, while they are allowing 23.8 points against per game this season. Ethan Vasko has completed 57.3% of his passes for 763 yards, six touchdowns, and three interceptions, while Evan Dickens has rushed for 297 yards and two scores. Donte Lee Jr has caught nine passes for 208 yards and three scores this year. 

Old Dominion Monarchs Betting Preview

The Old Dominion Monarchs are 2-1 this season after they defeated Virginia Tech by a score of 45-26 in their last game. Old Dominion led 28-0 at halftime and 45-13 in the fourth quarter, before allowing VT to score two garbage time touchdowns. The Monarchs out gained Virginia Tech by a total of 526-433, went 4-9 on third downs, and won the turnover battle by a margin of 2-1 in the game. Colton Joseph went 16-22 for 276 yards and two touchdowns, while Trequan Jones rushed for 101 yards and one score. Ja’Cory Thomas was the leading receiver with three catches for 83 yards in the game. The ODU defense recorded four sacks and eight tackles for loss in the victory. 

Old Dominion started the season with a 27-14 loss to Indiana, but did beat NC Central by a score of 54-6 after that. The Monarchs are averaging 37.7 points per game with 216.3 passing yards and 245.0 rushing yards per game, while they are allowing 19.7 points against per game this season. Colton Joseph has completed 67.6% of his passes for 629 yards, five touchdowns, and three interceptions, while also rushing for 291 yards and four scores. Ja’Cory Thomas has led the receivers with 11 catches for 193 yards and one touchdown this season. 

Why Old Dominion will beat Liberty 

Liberty has lost five of its last six games against non-AP-ranked teams.
Old Dominion has won each of its last three games against non-AP-ranked teams.
Liberty has failed to cover the spread in each of its last six games against non-AP-ranked teams.
Old Dominion has covered the spread in each of its last four games against non-conference opponents.

Total Points Facts

Each of Liberty’s last six games as an underdog have gone UNDER the total points line.
Each of Old Dominion’s last five games in Virginia have gone OVER the total points line.

Matchup/League Facts

Old Dominion ranks 6th among FBS teams for Q3 points per game this season (12.7).
Old Dominion ranks 130th among FBS teams for time of possession per game this season (25:20).
Liberty ranks T125th among FBS teams for red zone percentage this season (70.0).
Liberty ranks T124th among FBS teams for Q3 points per game this season (2.5).

Liberty vs Old Dominion Prediction 

Old Dominion is coming off of a bye week, but they have a ton of momentum after dominating Virginia Tech and battling Indiana for four quarters. The Monarchs have looked very strong in the non-conference and they have scored 99 points in their last two games. Liberty has not defeated a FBS team through their first four games and has scored just 13 points in each of their last two. I don’t really see how Liberty is going to keep this game close, especially with their issues at quarterback, so give me ODU to cover at home. 

David Racey is 18-9 (67%) in his last 27 College Football plays this season and is #1 on the leaderboard. Click here for his premium plays for this week!

David Racey's Pick: Old Dominion -16

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