Kentucky vs Vanderbilt Prediction 11/22/2025 Today’s College Football Picks

In this article we will formulate a Kentucky vs Vanderbilt prediction for this College Football game on Saturday, November 22nd at FirstBank Stadium in Nashville, Tennessee. Let’s take a look at the prediction for this week 13 matchup. 

Kentucky Wildcats Betting Preview

The Kentucky Wildcats are 5-5 (2-5) this season after they defeated Tennessee Tech by a score of 42-10 in their last game. Kentucky led 28-7 at halftime and added 14 points in the second half for the easy victory over an easy opponent. The Wildcats out gained Tennessee Tech by a total of 468-264, went 4-10 on third downs, and won the turnover battle by a total of 1-0 in the game. Cutter Boley went 18-21 for 236 yards and one touchdown, while Dante Dowdell rushed 13 times for 87 yards and one score. Kendrick Law led the receivers with 11 receptions for 124 yards in the win. The Kentucky defense recorded one sack and three tackles for loss in the game. 

Prior to that game, Kentucky defeated Florida by a score of 38-7 and Auburn by a score of 10-3. The Wildcats have won three games in a row and they are currently tied for 11th in the SEC standings. Kentucky has scored 25.9 points per game with 203.9 passing yards and 159.9 rushing yards per game, while they have allowed 23.1 points against per game this season. Cutter Boley has thrown for 1,780 yards, 13 touchdowns, and eight interceptions, while Kendrick Law has 47 catches for 519 yards and three scores this season. 

Vanderbilt Commodores Betting Preview

The Vanderbilt Commodores are 8-2 (4-2) this year after they defeated Auburn in overtime by a score of 45-38 in their last game. Vanderbilt trailed 20-10 at halftime, but they led 38-30 in the fourth, before blowing the lead and getting the win in overtime. The Commodores were out gained by a total of 563-544, went 7-12 on third downs, and lost the turnover battle by a total of 1-0 in the game. Diego Pavia went 25-33 for 377 yards and three touchdowns, while also rushing 18 times for 112 yards and one score. Tre Richardson led the receivers with three catches for 124 yards and one touchdown in the win. The Vanderbilt defense recorded two sacks and five tackles for loss in the game. 

Prior to that game, Vanderbilt lost to Texas by a score of 34-31, but did beat Missouri by a score of 17-10 before that. The Commodores have won three of their last four games and they are currently tied for fifth in the SEC standings. Vanderbilt has scored 38.3 points per game with 258.4 passing yards and 185.2 rushing yards per game, while they have allowed 22.2 points against per game this season. Diego Pavia has thrown for 2,440 yards, 21 touchdowns, and five interceptions, while also leading the rushing attack with 613 yards and seven scores on 117 carries this year. 

Why the Kentucky Wildcats will win

• The road team has won each of the last four games between Kentucky and Vanderbilt.
• Vanderbilt has lost 17 of its last 21 games in November.
• Kentucky has covered the spread in seven of its last eight games in November.
• Vanderbilt has failed to cover the spread in four of its last five November games at FirstBank Stadium.

Total Points Facts

• Each of Vanderbilt’s last four games against non-AP-ranked teams have gone OVER the total points line.
• Four of Kentucky’s last five games as an underdog in Tennessee have gone UNDER the total points line.

Matchup/League Facts

• Vanderbilt ranks T7th among FBS teams for Q4 points per game this season (10.4).
• Vanderbilt ranks 8th among FBS teams for average point differential in fourth quarters this season (+5.3).
• Kentucky ranks 22nd among FBS teams for time of possession per game this season (32:02).
• Kentucky ranks T23rd among FBS teams for interceptions this season (11).

Kentucky vs Vanderbilt Prediction 

Kentucky comes into this contest looking to extend their three game winning streak and they have allowed just 20 total points in those three wins. The Wildcats have seen their offense take a step forward and they are playing with plenty of confidence right now. Vanderbilt has won three of their last four games, but they did have trouble with a bad Auburn team last time out. The Commodores are having another special season, but their defense is vulnerable and they haven’t covered this number in any of their last five games. Take Kentucky and the points here.

David Racey is 128-108 (54%) in College Football this season and is one of the top College Football Handicappers on the site. Click here for his premium plays for the week!

David Racey's Pick: Kentucky +9.5