Kansas vs Iowa State Prediction 11/22/2025 Today’s College Football Picks

The Kansas Jayhawks and the Iowa State Cyclones meet Saturday in college football action from Jack Trice Stadium. Here’s a Kansas vs Iowa State prediction. We will look at this from a betting perspective and determine the best Kansas vs Iowa State pick. We will examine the recent form and player performances for both teams, as well as the recent betting trends and streaks pertaining to this matchup. As we conclude, we will tie it all together with a summary that produces a sensible pick for a favorable betting outcome in this game.

Kansas Jayhawks Betting Preview

The Jayhawks put up a 3-1 run over their first four games this year, losing to Missouri among wins versus Fresno State, Wagner and West Virginia. Kansas would go 2-3 over the next five with losses to Cincinnati, Texas Tech and Kansas State mixed with wins over UCF and Oklahoma State. On November 1 in the 38-21 victory versus the Cowboys, Kansas scored 28 points in the second half on the way to the win. The offense gathered 342 yards with 232 rush yards and 5.9 yards per play, going 6-of-10 on third-down tries as well. Defensively the Jayhawks gave up 316 total yards and 19 first downs with 5.1 yards per play on average.

In their latest matchup versus Arizona back on November 8, the Jayhawks fell back into the loss column. Kansas was up 17-14 by the break but got outscored 10-3 from there in a tough result 24-20. QB Jalon Daniels put up a 15-of-29 line for 199 yards and one TD while also leading the rush on 14 carries for 74 yards and another score. Tops in receiving was Emmanuel Henderson with five grabs for 65 yards and a touchdown in the losing effort for Kansas.

Iowa State Cyclones Betting Preview

Over on the Iowa State side, they kicked things off with a string of wins this year over Kansas State, South Dakota, Iowa, Arkansas State and Arizona. The Cyclones hit the skids in the next four though, losing to Cincinnati, Colorado, BYU and Arizona State in succession. In the loss to the Sun Devils 24-19 on November 1, the Cyclones gave up 14 points in the second quarter and never recovered. Iowa State posted 336 yards of offense with 21 first downs but went just 2-of-14 on third-down conversion attempts. The defense came up with three takeaways but did give up 290 yards on the ground in the losing effort.

Back on November 8 versus TCU in their most recent outing, the Cyclones were up by a field goal in the first half. Iowa State had to hang on (and score twice in the fourth) but won it 20-17 in the end. QB Rocco Becht put up 111 yards with one TD and two picks on 9-of-24 passing and Carson Hansen led the rush with 28 carries for 108 yards and a TD. Chase Sowell led the receivers with just 31 yards on four catches in the winning effort for the Cyclones.

Kansas Jayhawks @ Iowa State Cyclones Betting Trends: Week 13

Iowa State Cyclones Player Prop Facts

• Heading into Week 13, Brett Eskildsen ranks 14th amongst qualified players for Yards Per Reception (18.9) this season.

Kansas Jayhawks Player Prop Facts

• Heading into Week 13, Jalon Daniels is one of only nine players in the FBS to record 20+ passing TDs and throw less than five INTs this season.

Matchup/League Facts

• Iowa State ranks T32nd among FBS teams for Q4 opponent points per game this season (4.8).
• Iowa State ranks T36th among FBS teams for 4th down conversion percentage this season (61.9).
• Kansas ranks T118th among FBS teams for Q1 opponent points per game this season (8.0).
• Kansas ranks T22nd among FBS teams for Q1 points per game this season (8.0).

Kansas vs Iowa State Prediction

I’ll lean toward Kansas. You could probably make a case either way here, though. The Jayhawks had a bad second half in their last matchup versus Arizona and ended up with 369 total yards, 19 first downs and 6-of-17 on third-down tries. The defense gave up 323 yards on the other side with 5.4  yards per play, 18 first downs and 5-of-13 on third downs. That makes fewer than 21 points in three of the last four games for Kansas. The one time they eclipsed that total, they won (38-21 over Oklahoma State).

As for Iowa State, they’ve been below 21 points in consecutive games. We could have a fairly low-scoring finish here, but it should be a good game to watch.

Andrew Jett's Pick: Kansas Jayhawks +4