Jacksonville State vs Southern Mississippi Prediction 9/27/2025 Today’s College Football Picks

The Jacksonville State Gamecocks and the Southern Miss Golden Eagles meet in week 5 college football action from M.M. Roberts Stadium on Saturday. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Jacksonville State Gamecocks vs. Southern Miss Golden Eagles prediction.

Jacksonville State Gamecocks Recap

The Jacksonville State Gamecocks come into this game looking to add on to their 45-10 win over Murray State last time out to sit at 2-2 on the year. After this game, Jacksonville State will head on the road for a game against Sam Houston.

Gamecocks Looking To Get Back Above .500

Gavin Wimsatt has thrown for 557 yards, 2 touchdowns and 2 interceptions on 56.3% passing while also rushing for 216 yards and 4 touchdowns. Cam Cook has rushed for a team-high 537 yards and 4 touchdowns. Brock Rechsteiner leads the Gamecocks with 191 receiving yards and 2 touchdowns while Caleb Coombs has a team-high 15 catches for 132 yards this season. On defense, Trevor Woods leads the Gamecocks with 24 total tackles including 16 solo tackles this season. As a unit, Jacksonville State has combined for 8 sacks and 3 interceptions so far this season.

Southern Miss Golden Eagles Recap

The Southern Miss Golden Eagles come into this game looking to bounce back from a 30-20 loss to Louisiana Tech last time out to sit at 2-2 on the year. After this game, the Golden Eagles will head on hte road for a game against Georgia Southern.

Southern Miss Looking To Rebound

Braylon Braxton has thrown for 1,084 yards, 9 touchdowns and 3 interceptions on 65.8% passing while also rushing for 128 yards on 39 carries. Jeffery Pittman has 126 rushing yards and 2 touchdowns while Robert Briggs also has 116 rushing yards. Carl Chester leads Southern Miss with 13 grabs for 211 yards while Elijah Metcalf has 12 catches for 153 yards. Three more Golden Eagles have 100+ receiving yards, including Micah Davis who has a team-high 3 receiving touchdowns so far this season. On defense, Chris Jones has a team-high 45 total tackles while J’Mond Tapp has a team-high 3 sacks. Garrick Ponder also has a pair of sacks for the Golden Eagles. As a unit, USM’s defense has combined for 11 sacks and 6 interceptions so far this season.

Jacksonville State Gamecocks @ Southern Miss Golden Eagles Betting Trends: Week 5

Why the Southern Miss Golden Eagles will win

• The favorite has won 17 of Southern Miss’ last 18 games.
• Jacksonville State has lost each of its last four road games against non-conference opponents.
• Southern Miss has covered the spread in each of its last five September games as a home favorite.
• Jacksonville State has failed to cover the spread in three of its last four road games.
• Southern Miss has won the first half in 16 of its last 21 games against opponents from the Conference USA at M. M. Roberts Stadium.
• Southern Miss has won the first quarter in 21 of its last 28 games against opponents from the Conference USA at M. M. Roberts Stadium.

Why the Jacksonville State Gamecocks will win

• Southern Miss has lost each of its last 11 games against teams from Alabama.
• Jacksonville State has won three of its last four games in September.
• Southern Miss has failed to cover the spread in 12 of its last 13 games against teams from Alabama.
• Jacksonville State has covered the spread in six of its last seven games as an underdog against non-AP-ranked teams.
• Southern Miss has lost the first half in eight of its last 10 games against non-conference opponents.

Total Points Facts

• Each of Southern Miss’ last four games as a favorite against teams from Alabama have gone UNDER the total points line.
• Each of Jacksonville State’s last four road games in September have gone OVER the total points line.

Southern Miss Golden Eagles Player Prop Facts

• Heading into Week 5, Jeffery Pittman ranks T1st amongst qualified players for catch rate (100.0%) this season.

Jacksonville State Gamecocks Player Prop Facts

• Heading into Week 5, Cam Cook ranks 1st amongst FBS players for rushing attempts (89) this season.

Matchup/League Facts

• Southern Miss ranks T3rd among FBS teams for interceptions this season (6).
• Southern Miss ranks T132nd among FBS teams for 4th down conversion percentage this season (20.0).
• Jacksonville State ranks 8th among FBS teams for rushing yards per game this season (261.5).
• Jacksonville State ranks 125th among FBS teams for passing yards per game this season (147.8).

Jacksonville State Gamecocks vs. Southern Miss Golden Eagles Prediction

I’m on Southern Miss here. I haven’t given up on Southern Miss here, as I still like all of the moves that the Golden Eagles and the coaching staff come over from Marshall, and Jacksonville State I’m still not sold on based on the quarterback play being wildly inconsistent at ties so far this season. I think Southern Miss gets the job done at home here so give me the Golden Eagles in this one.