Iowa vs USC Prediction 11/15/2025 Today’s College Football Picks

The Iowa Hawkeyes and USC Trojans meet Saturday in college football action at Los Angeles Memorial Coliseum. Here’s a Iowa vs USC Prediction. This article will include a Iowa vs USC Pick.

Iowa Hawkeyes Betting Preview

The Iowa Hawkeyes beat Minnesota, lost to Oregon, and they play Michigan State next. The Iowa Hawkeyes have won 3 of their last 4 games. Mark Gronowski is completing 63.9 percent of his passes for 1,084 yards, 5 touchdowns, and 4 interceptions. Jacob Gill and Sam Phillips have combined for 409 receiving yards on 30 catches, while Kaden Wetjen has 17 receptions.

The Iowa Hawkeyes ground game is averaging 175.9 yards per contest, and Kamari Moulton leads the way with 522 yards and 2 touchdowns. Defensively, Iowa is allowing 13.7 points and 250.2 yards per game. Karson Sharar leads the Iowa Hawkeyes with 56 tackles, Max Liewellyn has 6 sacks and Zach Lutmer has 2 interceptions.

USC Trojans Betting Preview

The USC Trojans beat Nebraska and Northwestern, and they play Oregon next. The USC Trojans have won 8 of their last 10 games. Jayden Maiava is completing 66.2 percent of his passes for 2,614 yards, 17 touchdowns and 6 interceptions. Makai Lemon and Ja’Kobi Lane have combined for 1,457 receiving yards and 11 touchdowns, while Lake McRee has 21 receptions.

The USC Trojans ground game is averaging 200.2 yards per contest, and King Miller leads the way with 636 yards and 5 touchdowns. Defensively, USC is allowing 21.8 points and 346.8 yards per game. Eric Gentry leads the USC Trojans with 61 tackles, Braylan Shelby has 3.5 sacks and Bishop Fitzgerald has 5 interceptions.

Why the USC Trojans will win

• USC has won 18 of its last 19 home games against non-AP-ranked teams.
• Iowa has lost each of its last 11 games as an underdog against AP-ranked teams.
• USC has covered the spread in eight of its last nine games as a home favorite.
• Iowa has failed to cover the spread in nine of its last 11 games as an underdog against AP-ranked teams.

Why the Iowa Hawkeyes will win

• Iowa has won five of its last six November games as an underdog.
• Iowa has covered the spread in each of its last five November games as a road underdog.
• USC has failed to cover the spread in three of its last four games as a favorite against non-AP-ranked teams.

Total Points Facts

• Each of Iowa’s last five November games as an underdog have gone UNDER the total points line.
• Each of USC’s last four games against non-AP-ranked teams at United Airlines Field at the Los Angeles Memorial Coliseum have gone OVER the total points line.

USC Trojans Player Prop Facts

• Heading into Week 12, Makai Lemon ranks 3rd amongst FBS players for receiving yards (937) this season.

Iowa Hawkeyes Player Prop Facts

• Heading into Week 12, Mark Gronowski ranks T7th amongst FBS players for rushing touchdowns (12) this season.

Matchup/League Facts

• USC ranks 4th among FBS teams for H2 points per game this season (19.8).
• USC ranks T6th among FBS teams for average point differential in fourth quarters this season (+5.6).
• Iowa ranks T3rd among FBS teams for Q3 opponent points per game this season (1.4).
• Iowa ranks 4th among FBS teams for yards allowed per game this season (250.2).

Iowa vs USC Prediction

USC is the more talented team and has the explosive offense to pull away. If Iowa gets down a couple of scores early, I’ll be afraid due to a passing attack that’s nonexistent. However, we’re getting a full touchdown with an Iowa defense that’s one of the best in the country. Iowa was getting owned in the trenches last week against Oregon, but still allowed just 16 points and had a chance to win late. It’s not pretty, but Iowa is still a tough-minded team that doesn’t get blown out often. Iowa’s three losses this season have been decided by an average of 3.33 points. Give me the free touchdown with the Hawkeyes.

Randy Chambers's Pick: Iowa +7