Indiana vs Purdue Prediction 11/28/2025 Today’s College Football Picks

The Indiana Hoosiers and the Purdue Boilermakers meet in week 14 college football action from Ross-Ade Stadium on Friday. We will look at this from a betting perspective and determine the best bets for this game. Here’s an Indiana Hoosiers vs. Purdue Boilermakers prediction.

Indiana Hoosiers Recap

The Indiana Hoosiers come into this game looking to add on to their 31-7 win over Wisconsin prior to last week’s bye week to improve to 11-0 on the year. 

Hoosiers Looking To Stay Perfect

Fernando Mendoza leads Indiana in passing with 2,641 yards, 30 touchdowns and 5 interceptions on 73% passing while Roman Hemby has a team-high 714 rushing yards with 5 TDs and Kaelon Black has 663 rushing yards and 5 TDs as well this season. Khobie Martin has also added 402 rushing yard and 5 touchdowns. Omar Cooper Jr. has a team-high 55 catches for 740 yards and 10 touchdowns while Elijah Sarratt has 45 grabs for 609 yards and 10 touchdowns this season. E.J. Williams Jr. also has 404 receiving yards and 5 TDs. On defense, Louis Moore has a team-high 68 total tackles along with 5 interceptions while Rolijah Hardy has a team-high 7 sacs and Isaiah Jones has 5 sacks. Amare Ferrell also has 3 interceptions and Tyrique Tucker has 5.5 sacks as well this season. As a unit, Indiana’s defense has combined for 33 sacks and 15 interceptions so far this season.

Purdue Boilermakers Recap

The Purdue Boilermakers come into this game looking to shake off a 49-13 loss at the hands of Washington to fall to 2-9 on the year prior to last week’s bye week.

Boilermakers Looking For Massive First Big Ten Win

Ryan Browne has thrown for 1,915 yards, 9 touchdowns and 9 inteceptions on 59.8% passing while Malachi Singleton has thrown for 439 yards, 5 touchdowns and 2 picks on 59.4% passing. Devin Mockobee leads the Boilermakers in rushing with 521 rushing yards and 4 touchdowns and Michael Jackson III has a team-high 57 catches for 504 yards and Nitro Tuggle has 29 grabs for 420 yards and 4 TDs this season. On defense, Mani Powell has a team-high 103 total tackles along with 5 sacks while CJ Nunnally IV has 5 sacks as well this season. As a unit, Purdue’s defense has combined for 24 sacks and 4 interceptions so far this season.

Indiana Hoosiers @ Purdue Boilermakers Betting Trends: Week 14

Why the Purdue Boilermakers will win

• Purdue has won five of its last six home games against teams from Indiana.
• Indiana has lost three of its last four games at Ross-Ade Stadium.
• The team ranked 2nd in the AP Poll has failed to cover the spread in eight of its last 10 games.
• The underdog has covered the spread in four of Purdue’s last five games at Ross-Ade Stadium.
• Purdue has won the first quarter in each of its last three home games against conference opponents.

Why the Indiana Hoosiers will win

• Indiana has won each of its last 20 games against non-AP-ranked teams.
• Purdue has lost each of its last 17 games against conference opponents.
• Purdue has failed to cover the spread in each of its last four games as an underdog against teams from Indiana.
• Indiana has covered the spread in five of its last six November road games against non-AP-ranked teams.
• Indiana has won the first half in each of its last six games against conference opponents.
• Indiana has won the first quarter in each of its last 11 games against conference opponents.

Total Points Facts

• Eight of Indiana’s last nine road games in November have gone OVER the total points line.
• Each of Purdue’s last four games as a home underdog against teams from Indiana have gone OVER the total points line.

Purdue Boilermakers Player Prop Facts

• Heading into Week 14, Devin Mockobee is one of only 20 players averaging over 50.0 rushing yards and 20.0 receiving yards per game this season.

Indiana Hoosiers Player Prop Facts

• Heading into Week 14, Fernando Mendoza ranks T1st amongst FBS players for passing touchdowns (30) this season.

Matchup/League Facts

• Purdue ranks 136th among FBS teams for Q2 opponent points per game this season (13.1).
• Purdue ranks 135th among FBS teams for average point differential in second quarters this season (-7.6).
• Indiana has recorded the equal-most home wins by a margin of 10+ points of any FBS team this season (7).
• Indiana has recorded the equal-most home wins by a margin of 35+ points of any FBS team this season (4).

Indiana Hoosiers vs. Purdue Boilermakers Prediction

I’m on the under in this one. Curt Cignetti’s hinted at the ideology that he’s focusing on keeping guys healthy for the potential Big Ten title game and the college football playoffs and not necessarily keeping his foot on the gas for a full 60 minutes here. Purdue has not been able to do much of anything offensively in conference play and I think that the under is the way to go in this one. Give me the under here.

Chris Ruffolo's Pick: Under 53.5