Illinois vs Indiana Prediction 9/20/2025 Today’s College Football Picks

In this article, we will formulate an Illinois vs Indiana Prediction for this College Football Week 4 game on Saturday, September 20th at the Memorial Stadium (Bloomington, IN). Let’s take a look at the prediction for this College Football matchup.

Indiana Hoosiers Preview

Indiana has a 3-0 record this season and are coming off a 73-0 home victory over Indiana State. Offensively, the Hoosiers average 52.0 points per game, which ranks 8th in the nation. Defensively, they allow 7.7 points per game, which ranks 6th in the nation. Indiana averages 591.7 total yards per game, with 307.7 rushing yards and 284.0 passing yards per game. They allow 220.7 total yards per game, 115.3 of them rushing and 105.3 passing yards per game.

Fernando Mendoza leads the Hoosiers with 55/76 completed passes and 708 total passing yards. He also adds 72 rushing yards and 2 touchdowns. Kaelon Black leads the team in rushing yards, with 217 and 1 touchdown, while Lee Beebe adds 209 rushing yards and 1 touchdown. Elijah Sarratt has a team-high 15 caught passes for 164 receiving yards, and has 3 touchdowns. Omar Cooper Jr. has caught 13 passes for 299 yards, and 4 touchdowns.

Defensively, Louis Moore has a team-high 17 total tackles, 10 of them solo. D’Angelo Ponds adds 10 total tackles, 9 of them solo and 1 interception. Isaiah Jones leads the Hoosiers in sacks, with 2, while Louis Moore has a team-high 2 total interceptions.

Illinois Fighting Illini Preview

Illinois has a 3-0 record this season and are coming off a 38-0 home victory over Western Michigan. Offensively, the Illini average 45.0 points per game, which ranks 18th in the nation. Defensively, they allow 7.3 points per game, which ranks 5th in the nation. Illinois averages 405.7 total yards per game, with 164.7 rushing yards and 241.0 passing yards per game. They allow 267.7 total yards per game, 74.0 of them rushing and 193.7 passing yards per game.

Luke Altmyer leads Illinois with 56/78 completed passes and 709 total passing yards. He also adds 1 rushing touchdown. Kaden Feagin leads the team in rushing yards, with 222 and 3 touchdowns, while Ca’Lil Valentine adds 158 rushing yards and 2 touchdowns. Hank Beatty has a team-high 19 caught passes for a team-high 289 receiving yards, and has 1 touchdown. Justin Bowick has caught 8 passes for 86 yards, and 3 touchdowns.

Defensively, Miles Scott has a team-high 14 total tackles, 11 of them solo. Tanner Heckel adds 4 total tackles, 3 of them solo and 1 interception. Gabe Jacas leads Illinois in sacks, with 3.5, while Tanner Heckel has a team-high 1 interception.

Illinois vs Indiana Prediction

In their previous meeting back in 2023, Illinois won 48-45 at home in overtime, not covering the spread, as the game went over the point total. Indiana has won their four meetings before that, and are 3-1 in their last home meetings against Illinois. Indiana is 4-1 ATS in their last 5 meetings.

In this Illinois vs Indiana Prediction, Indiana is coming as -4.5-point home favorites. Both teams are red-hot to start the season, as they are both undefeated in their three games played. Indiana’s offense is scorching hot, having scored 129 total points in their last two games, while Illinois has scored 38+ in their last three games. Their most recent meeting had 93 points in overtime, and I expect another high-scoring affair today. Take the over 52.5 points in this one.