Oklahoma State Cowboys safety Kenneth Harris (23) knocks the ball away as Houston Cougars wide receiver Amare Thomas (0) misses the catch during a college football game between the Oklahoma State Cowboys (OSU) and the Houston Cougars at Boone Pickens Stadium in Stillwater, Okla., Saturday, Oct. 11, 2025. Houston won 39-17.
BRYAN TERRY/THE OKLAHOMAN / USA TODAY NETWORK via Imagn Images

Houston vs Arizona State Prediction 10/25/2025 Today’s College Football Picks

Pick details

Houston (6-1) vs Arizona State (5-2)

October 25, 2025 at 08:00 PM EDT

The Line: Betting Odds: Arizona State -7.5 — Over/Under: +46.5

(Get latest betting odds)

In this article, we will formulate a Houston vs Arizona State Prediction for this College Football Week 9 game on Saturday, October 25th. Let’s take a look at the prediction for this College Football matchup.

Arizona State Sun Devils Preview

Arizona State has a 5-2 record this season and is sitting 3rd in the Big 12. They are 4-3 ATS, 2-5 in Over/Under and have a 4-0 home record and a 1-2 away record. Arizona State is coming off a 26-22 home win against Texas Tech and will face Iowa State, West Virginia and Colorado next.

Offensively, Arizona State averages 26.0 points per game, ranking 82nd in the nation, while defensively, they allow 24.3 points per game, which is 69th. Arizona State averages 397.6 total yards per game (211.7 passing and 185.9 rushing), while allowing 327.6 total yards per game (110.9 rushing and 216.7 passing).

Sam Leavitt leads Arizona State with 1,358 passing yards with 62.3% completed passes and 9 touchdowns. Raleek Brown leads the team in rushing yards with 642, while Jordyn Tyson has a team-high 57 receptions for 628 receiving yards. Defensively, Keyshaun Elliot has a team-high 54 total tackles (30 of them solo), while Keyshaun Elliot leads the team in sacks, with 4.0, and Martell Hughes has a team-high 2 interceptions.

Houston Cougars Preview

Houston has a 6-1 record this season and is sitting 5th in the Big 12. They are 5-2 ATS, 5-2 in Over/Under and have a 3-1 home record and a 3-0 away record. Houston is coming off a 31-28 home win against Arizona and will face West Virginia, UCF and Texas Christian next.

Offensively, Houston averages 29.4 points per game, ranking 63rd in the nation, while defensively, they allow 19.0 points per game, which is 27th. Houston averages 380.9 total yards per game (211.3 passing and 169.6 rushing), while allowing 317.1 total yards per game (123.6 rushing and 193.6 passing).

Conner Weigman leads Houston with 1,380 passing yards with 62.0% completed passes and 11 touchdowns. Dean Connors leads the team in rushing yards with 538, while Tanner Koziol has a team-high 36 receptions for 350 receiving yards. Defensively, Carlos Allen and Jalen Garner have a team-high 48 total tackles (20 and 21 of them solo), while Brandon Mack leads the team in sacks, with 3.0, and Will James has a team-high one interception.

Houston vs Arizona State Prediction

In this Houston vs Arizona State Prediction, Arizona State is coming as -7.5-point home favorites, with the total set at 47 points. The wrong team is favored in this matchup, as Houston has a better record, having lost only once this season, and are better both offensively and defensively. They are winning by an average of 10.4 points this season, so they are a live road dog in this spot. Take the Houston Cougars and get the +7.5 points in this one.

Nikos Lagouretos's Pick: Houston +7.5

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