Georgia Southern vs USC Prediction 9/6/2025 Today’s College Football Picks

The Georgia Southern Eagles and the USC Trojans meet in week 2 college football action from the Los Angeles Memorial Coliseum on Saturday. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Georgia Southern Eagles vs. USC Trojans prediction.

Georgia Southern Eagles Recap

The Georgia Southern Eagles come into this game looking to bounce back from a 42-14 loss at the hands of the Fresno State Bulldogs last time out to slip to 0-1 this season. After this game, the Eagles will head home for a game against the Jacksonville State Gamecocks.

Eagles Looking For Bounce Back

JC French IV threw for 158 yards, 2 touchdowns and an interception on 17 of 28 passing while OJ Arnold had 9 carries for 41 yards and Camden Brown led Georgia Southern’s receiving group with 55 receiving yards and a touchdown coming on 4 catches. Josh Dallas had a team-high 5 grabs for 48 yards while River Helms added a receiving TD as well. On defense, Jayden Davis led the Eagles with 10 total tackles including 6 solo tackles while Chance Gamble and Brandon Tyson each had an interception on in the losing effort.

Why the Georgia Southern Eagles will win

• Georgia Southern has won five of its last six games as an underdog.
• Georgia Southern has covered the spread in eight of its last nine September games against non-AP-ranked teams.

USC Trojans Recap

The USC Trojans come into this game looking to add on to their 73-13 rout over Missouri State last time out to sit at 1-0 on the year. After this game, the Trojans will head on the road for a game against the Purdue Boilermakers. 

Trojans Looking To Add On To Rout

Jayden Maiava threw for 295 yards and 2 touchdowns on 15 of 18 passing while Husan Longstreet threw for 69 yards and a score on 9 of 9 passing while also rushing for 54 yards and 2 TDs. Maiava also had a TD while King Miller led USC with 4 carries for 80 yards and a score. Waymond Jordan also chipped in 42 rushing yards and a touchdown. Makai Lemon led the Trojans with 7 grabs for 90 yards while Eli Sanders had 73 receiving yards with a touchdown and Lake McRee added 72 receiving yards and a TD. Carson Tabaracci also chipped in a receiving score. On defense, Elijah Newby led the Trojans with 5 total tackles including 4 solo tackles while Braylan Shelby had a pair of sacks and Kennedy Urlacher, Kameryn Fountain and Jide Abasiri each had a sack. Bishop Fitzgerald added a 39-yard pick-six for the USC defense and Garrett Pomerantz added an interception of his own.

Why the USC Trojans will win

• USC has won each of its last 10 September games against non-AP-ranked teams.
• Georgia Southern has lost each of its last three games against non-conference opponents.
• USC has covered the spread in each of its last six games as a favorite in California.
• Georgia Southern has failed to cover the spread in each of its last three games against non-conference opponents.

Total Points Facts

• Five of USC’s last six home games have gone OVER the total points line.
• Five of Georgia Southern’s last six road games in September have gone UNDER the total points line.

Georgia Southern Eagles vs. USC Trojans Prediction

I’m on USC here. It’s a huge number, and maybe I’m backing USC out of spite after Georgia Southern burned me last week, but I just think that the Eagles looked horrible last week and I’m in no position to want to back them in any way, shape or form here. The defense is still a huge problem, and now you have to take on a Trojan team that just hung 73 on Missouri State? I look for this one to be over fairly quickly and for USC to have this one wrapped up, done and dusted by halftime. Give me USC.