Eastern Michigan vs Buffalo Prediction 10/4/2025 Today’s College Football Picks

In this article, we will formulate an Eastern Michigan vs Buffalo Prediction for this College Football Week 6 game on Saturday, October 4th at the UB Stadium. Let’s take a look at the prediction for this College Football matchup.

Buffalo Preview

Buffalo has a 2-3 record this season and are sitting on the 7th place of the MAC. They are 2-2-1 ATS, 2-3 in Over/Under and have a 1-2 home record and 1-1 away record. The Bulls are coming off a 17-20 home loss by Connecticut and are playing Massachusetts and Akron next.

Offensively, the Bulls average 24.0 points per game, which ranks 91st in the nation. Defensively, they allow 19.6 points per game, which is 45th. Buffalo averages 342.4 total yards per game, with 175.2 rushing yards and 167.2 passing yards per game. They allow 334.0 total yards per game, with 125.8 rushing and 208.2 passing yards per game.

Ta’Quan Roberson leads the Bulls with 662 passing yards and 62.1% completed passes. Al-Jay Henderson leads the team in rushing yards, with 337, while Victor Snow has a team-high 23 caught passes for 274 receiving yards, and has three touchdowns. Defensively, Khalil Murdock has a team-high 53 total tackles, 23 of them solo. Kobe Stewart leads the Bulls in sacks, with 2.5, while Mitchell Gonser has one interception.

Eastern Michigan Preview

Eastern Michigan has a 1-4 record this season and are sitting on the 13th place of the MAC. They are 2-3 ATS, 3-2 in Over/Under and have a 1-1 home record and 0-3 away record. The Eagles are coming off a 13-24 road loss in Central Michigan and are playing Northern Illinois and Miami (OH) next.

Offensively, the Eagles average 24.0 points per game, which ranks 92nd in the nation. Defensively, they allow 36.6 points per game, which is 128th. Eastern Michigan averages 374.0 total yards per game, with 140.4 rushing yards and 233.6 passing yards per game. They allow 494.6 total yards per game, with 278.8 rushing and 215.8 passing yards per game.

Noah Kim leads the Eagles with 1168 passing yards and 63.4% completed passes. Dontae McMillan leads the team in rushing yards, with 416, while Terry Lockett Jr. has a team-high 19 caught passes for 263 receiving yards, and has one touchdown. Defensively, Bryce Llewellyn has a team-high 41 total tackles, 11 of them solo. Sterling Miles leads the Eagles in sacks, with two, while Bryce Llewellyn has one interception.

Eastern Michigan Eagles @ Buffalo Bulls Betting Trends: Week 6

Buffalo Bulls Player Prop Facts

• Heading into Week 6, Red Murdock leads the league for forced fumbles (3) this season.

Eastern Michigan Eagles Player Prop Facts

• Heading into Week 6, Ben Prosper ranks T1st amongst qualified players for catch rate (100.0%) this season.

Matchup/League Facts

• Buffalo ranks T12th among FBS teams for Q1 opponent points per game this season (1.4).
• Buffalo ranks 15th among FBS teams for red zone percentage against this season (71.4).
• Eastern Michigan has suffered the equal-most road losses by a margin of 10+ points of any FBS team this season (3).
• Eastern Michigan ranks 136th among FBS teams for rushing yards allowed per game this season (278.8).

Eastern Michigan vs Buffalo Prediction

In their previous meeting last season, Buffalo won 37-20 on the road. Buffalo is 4-1 in their last 5 meetings against Eastern Michigan, but both teams are tied 2-2 wins in their last 4 meetings in Buffalo. Over is 6-1 in their last 7 meetings.

In this Eastern Michigan vs Buffalo Prediction, Buffalo is coming as -9.5-point home favorites, with the total set at 49.5 points. Both teams are coming off defeats in their previous matches, but Eastern Michigan has been struggling mightily on the road, having lost all of their 3 road games. They have a bottom-8 defense, allowing 36.6 points per game, and have been losing by an average of 12.5 points per game this season. Buffalo won by 17 points last season, and I expect them to win comfortably again today at home. Take Buffalo and lay the -9.5 points in this one.