Eastern Kentucky vs Louisville Prediction 8/30/2025 Today’s College Football Picks

In this article we will formulate an Eastern Kentucky vs Louisville prediction for this College Football game on Saturday, August 30th at L&N Federal Credit Union Stadium in Louisville, Kentucky. Let’s take a look at the prediction for this week 1 matchup. 

Eastern Kentucky Colonels Betting Preview

The Eastern Kentucky Colonels went 8-5 (6-2) last year, which was tied for second in the United Athletic Conference standings with Tarleton State and Southern Utah. Eastern Kentucky started the 2024 season with losses to Mississippi State by a score of 56-7 and Western Kentucky by a score of 31-0. The Colonels picked up wins against West Georgia, Morehead State, Robert Morris, Utah Tech, Tarleton State, Central Arkansas, Austin Peay, and North Alabama, while they lost to Mississippi State, Western Kentucky, Southern Utah, and Abilene Christian. The Colonels did qualify for the FCS playoffs, but they lost to Villanova by a score of 22-17 in their first game. 

Louisville Cardinals Betting Preview

The Louisville Cardinals were 9-4 (5-3) last season and they finished tied for fourth in the ACC standings with Syracuse, Georgia Tech, and Duke. Louisville opened the 2024 season with a 62-0 win over Austin Peay and had a very successful season. The Cardinals got wins against Austin Peay, Jacksonville State, Georgia Tech, Virginia, Boston College, Clemson, Pittsburgh, and Kentucky, while they lost to Notre Dame, SMU, Miami, and Stanford. The Cardinals went to the Sun Bowl, where they beat Washington by a score of 35-34. Louisville scored 36.5 points per game last year, which was ranked 9th in the nation, while they allowed 24.1 points against per game, which was 56th. 

This year, Louisville will have Miller Moss under center, who transferred from USC. The Cardinals should have a very strong passing attack this year and the running backs are solid, but the offensive line is most likely going to take a step back from last season’s very impressive unit. On defense, Louisville had a very good 2024 season and they should be just as good this year. Louisville’s front seven should be one of the best in the ACC and should make up for just an average secondary. We saw the Cardinals play very well at times last year and I think we will see a more consistent team here. 

Why Louisville will beat Eastern Kentucky

• Louisville has won six of its last seven games against non-conference opponents at L&N Federal Credit Union Stadium.
• Louisville has covered the spread in four of its last five games against non-conference opponents.

Total Points Facts

• Four of Louisville’s last five games against non-AP-ranked teams have gone OVER the total points line.

Matchup/League Facts

• Louisville ranked 6th among FBS teams for average point differential in third quarters last season (+6.3).
• Louisville ranked 9th among FBS teams for points per game last season (36.5).

Eastern Kentucky vs Louisville Prediction 

Louisville comes into this season with high expectations and they should cruise to an easy win here. The Cardinals blew by Austin Peay by a score of 62-0 in their first game last year and they will have another blowout win here. Eastern Kentucky is a decent FCS program and they could have a solid year, but they don’t have the playmakers needed to trouble a team like Louisville. I think the Louisville team total is worth a look, as they should score early and often, but I will just take them to cover.