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Duke vs Tulane Prediction 9/13/2025 Today’s College Football Picks
Pick details
Duke (1-1) vs Tulane (2-0)
September 13, 2025 at 08:00 PM EDT
The Line: Betting Odds: Tulane -3 — Over/Under: +52.5
In this article, we will formulate a Duke vs Tulane Prediction for this College Football Week 3 game on Saturday, September 13th at the Yulman Stadium. Let’s take a look at the prediction for this College Football matchup.
Jake Retzlaff had 13/24 passes, a team-high 125 passing yards and one touchdown. Zuberi Mobley added a team-high 82 rushing yards, while Bryce Bohanon caught 5 passes for 62 yards. Defensively, Dickson Agu had 11 total tackles, while Harvey Dyson had 0.5 sacks. Tulane had no interceptions.
Darian Mensah had 23/34 passes, a team-high 334 passing yards and two touchdowns but also threw one interception. Jaquez Moore added a team-high 30 rushing yards, while Andrel Anthony caught 5 passes for 58 yards and two touchdowns. Defensively, Caleb Weaver had 9 total tackles, while Vincent Anthony Jr. had 2.5 sacks. Duke had no interceptions.
In this Duke vs Tulane Prediction, Tulane is coming in as -3-point home favorites, with the total set at 52.5 points. Tulane is looking better so far this season, with a perfect 2-0 record, having won their only home game by 20 points against NorthWestern. On the flip side, Duke does not look good this season, and have lost their only road game this season by 20-52 in Ole Miss. I like the hosts in this spot as small home favorites, so take the Tulane Green Wave to win and cover in this one.
Tulane Green Wave Preview
The Green Wave have a 2-0 record this season and are ranked as No.44 in the College Football Top 136 Team Rankings for 2025. Ohio State is number 1, Penn State is number 2 and LSU is number 3 in the rankings. The Green Wave are coming off a 33-31 road victory in South Alabama. Tulane got outgained by their opponents by 421-406 yards. They had 16/27 completed passes, 165 passing yards, 241 rushing yards, with South Alabama winning the turnover battle 2-1. The Green Wave went 9-17 in third down efficiency and had 11-87 penalties.Jake Retzlaff had 13/24 passes, a team-high 125 passing yards and one touchdown. Zuberi Mobley added a team-high 82 rushing yards, while Bryce Bohanon caught 5 passes for 62 yards. Defensively, Dickson Agu had 11 total tackles, while Harvey Dyson had 0.5 sacks. Tulane had no interceptions.
Duke Blue Devils Preview
The Blue Devils have a 1-2 record this season and are ranked as No.43 in the College Football Top 136 Team Rankings for 2025. Ohio State is number 1, Penn State is number 2 and LSU is number 3 in the rankings. The Blue Devils are coming off a 19-45 home defeat by Illinois. Duke outgained their opponents by 438-419 yards. They had 25/39 completed passes, 356 passing yards, 82 rushing yards, with Illinois winning the turnover battle 0-5. The Blue Devils went 4-10 in third down efficiency and had 6-69 penalties.Darian Mensah had 23/34 passes, a team-high 334 passing yards and two touchdowns but also threw one interception. Jaquez Moore added a team-high 30 rushing yards, while Andrel Anthony caught 5 passes for 58 yards and two touchdowns. Defensively, Caleb Weaver had 9 total tackles, while Vincent Anthony Jr. had 2.5 sacks. Duke had no interceptions.
Duke vs Tulane Prediction
Duke has won all three previous meetings against Tulane, having covered the spread in all three, and winning their only visit in Tulane back in 2015 by 37-7.In this Duke vs Tulane Prediction, Tulane is coming in as -3-point home favorites, with the total set at 52.5 points. Tulane is looking better so far this season, with a perfect 2-0 record, having won their only home game by 20 points against NorthWestern. On the flip side, Duke does not look good this season, and have lost their only road game this season by 20-52 in Ole Miss. I like the hosts in this spot as small home favorites, so take the Tulane Green Wave to win and cover in this one.
