Duke vs Syracuse Prediction 9/27/2025 Today’s College Football Picks

In this article, we will formulate a Duke vs Syracuse Prediction for this College Football Week 5 game on Saturday, September 27th at the JMA Wireless Dome. Let’s take a look at the prediction for this College Football matchup.

Syracuse Preview

Syracuse has a 3-1 record this season and are sitting on the 2nd place of the Atlantic Coast Conference. They are 2-1-1 ATS, 3-1 in Over/Under and have a 2-0 home record and 1-0 away record. They rank 33rd in the AP Power Rankings. The Orange are coming off a 34-21 away victory over Clemson and are playing Duke, SMU and Pitt next.

Offensively, the Orange average 38.2 points per game, which ranks 33rd in the nation. Defensively, they allow 27.5 points per game, which is 96th. Syracuse averages 472.8 total yards per game, with 119.0 rushing yards and 353.8 passing yards per game. They allow 455.0 total yards per game, with 158.8 rushing and 296.3 passing yards per game.

Steve Angeli leads the Orange with 1316 passing yards and 62.8% completed passes. Yasin Willis leads the team in rushing yards, with 233, while Darrell Gill Jr. has a team-high 14 caught passes for 310 receiving yards, and has three touchdowns.

Defensively, Demetres Samuel Jr. has a team-high 22 total tackles, 15 of them solo. Braheem Long Jr. leads the Orange in sacks, with 2.0, while Demetres Samuel Jr. has one interception.

Duke Preview

Duke has a 2-2 record this season and are sitting on the 4th place of the Atlantic Coast Conference. They are 1-3 ATS, 4-0 in Over/Under and have a 2-1 home record and 0-1 away record. They rank 71st in the AP Power Rankings. The Blue Devils are coming off a 45-33 home victory over North Carolina State and are playing Syracuse, California and Georgia Tech next.

Offensively, the Blue Devils average 34.0 points per game, which ranks 54th in the nation. Defensively, they allow 32.2 points per game, which is 112th. Duke averages 464.0 total yards per game, with 132.3 rushing yards and 331.8 passing yards per game. They allow 413.8 total yards per game, with 153.3 rushing and 260.5 passing yards per game.

Darian Mensah leads the Blue Devils with 1305 passing yards and 67.3% completed passes. Anderson Castle leads the team in rushing yards, with 193, while Cooper Barkate has a team-high 17 caught passes for 337 receiving yards, and has one touchdown.

Defensively, DaShawn Stone has a team-high 31 total tackles, 15 of them solo. Vincent Anthony Jr. leads the Blue Devils in sacks, with 5.0, while DaShawn Stone has one interception.

Duke Blue Devils @ Syracuse Orange Betting Trends: Week 5

Syracuse Orange Player Prop Facts

• Heading into Week 5, Steve Angeli ranks 2nd amongst FBS players for passing yards (1316) this season.

Duke Blue Devils Player Prop Facts

• Darian Mensah has recorded 250+ passing yards in four consecutive games – equal-longest streak in the FBS, heading into Week 5.

Matchup/League Facts

• Syracuse ranks 3rd among FBS teams for passing yards per game this season (353.8).
• Syracuse ranks 134th among FBS teams for passing yards allowed per game this season (296.3).
• Duke ranks 10th among FBS teams for passing yards per game this season (331.8).
• Duke ranks 124th among FBS teams for time of possession per game this season (26:12).

Duke vs Syracuse Prediction

Duke is 2-1 in their three meetings against Syracuse, having won their most recent meeting back in 2020 by 38-24 on the road. Their last two meetings have gone over the total.

In this Duke vs Syracuse Prediction, Duke is coming as -5.5-point road favorites, with the total set at 60 points. Syracuse has won three straight games, and have covered their last two. Duke’s only road game was a loss and they failed to cover the spread, and their defense looks terrible right now, having allowed 33+ points in their last three games. I like home team as an underdog in this matchup, so take Syracuse and the +5.5 points in your back pocket in this one.