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Duke vs Clemson Prediction 11/1/2025 Today’s College Football Picks
Pick details
Duke (4-3) vs Clemson (3-4)
November 1, 2025 at 12:00 PM EDT
The Line: Betting Odds: Clemson -2.5 — Over/Under: +54.5
The Duke Blue Devils and Clemson Tigers meet Saturday in college football action at Memorial Stadium. Here’s a Duke vs Clemson Prediction. This article will include a Duke vs Clemson Pick.
The Duke Blue Devils beat Cal, lost to Georgia Tech, and they play UCONN next. Duke has split its last 6 games. Darian Mensah is completing 70.3 percent of his passes for 2,211 yards, 17 touchdowns, and 2 interceptions. Cooper Barkate and Que’Sean Brown have combined for 1,090 receiving yards and 5 touchdowns, while Sahmir Hagans has 24 receptions.
The Duke Blue Devils ground game is averaging 144.3 yards per contest, and Nate Sheppard leads the way with 497 yards and 4 touchdowns. Defensively, Duke is allowing 5.7 points and 375.9 yards per game. Caleb Waver leads the Duke Blue Devils with 50 tackles, Vincent Anthony Jr. has 6.5 sacks and Moussa Kane has 2 interceptions.
The Clemson Tigers ground game is averaging 116.4 yards per contest, and Adam Randall leads the way with 433 yards and 4 touchdowns. Defensively, Clemson is allowing 20.9 points and 337.6 yards per game. Sammy Brown leads the Clemson Tigers with 48 tackles, Will Heldt has 3.5 sacks and Ricardo Jones has 3 interceptions.
I’m not excited to back Duke, as this team is poorly coached and has some questionable performances, but Clemson in the favorite role is nuts. Clemson has been one of the biggest underachievers in college football. Clemson can’t run the ball, doesn’t finish drives, and you can pass on this defense. Duke is one of the best passing offenses in the country, so there should be some success there. Clemson is the more talented team and should be favored at home, but I’m not laying points with this group regardless. It’s Duke and the points or pass for me.
Duke Blue Devils Betting Preview
The Duke Blue Devils beat Cal, lost to Georgia Tech, and they play UCONN next. Duke has split its last 6 games. Darian Mensah is completing 70.3 percent of his passes for 2,211 yards, 17 touchdowns, and 2 interceptions. Cooper Barkate and Que’Sean Brown have combined for 1,090 receiving yards and 5 touchdowns, while Sahmir Hagans has 24 receptions.
The Duke Blue Devils ground game is averaging 144.3 yards per contest, and Nate Sheppard leads the way with 497 yards and 4 touchdowns. Defensively, Duke is allowing 5.7 points and 375.9 yards per game. Caleb Waver leads the Duke Blue Devils with 50 tackles, Vincent Anthony Jr. has 6.5 sacks and Moussa Kane has 2 interceptions.
Clemson Tigers Betting Preview
The Clemson Tigers beat Boston College, lost to SMU, and they play Florida State next. Clemson has split its last 6 games. Cade Klubnik is completing 65.8 percent of his passes for 1,530 yards, 11 touchdowns, and 5 interceptions. Bryant Wesco Jr. and T.J. Moore have combined for 944 receiving yards and 9 touchdowns, while Antonio Williams has 23 receptions.
The Clemson Tigers ground game is averaging 116.4 yards per contest, and Adam Randall leads the way with 433 yards and 4 touchdowns. Defensively, Clemson is allowing 20.9 points and 337.6 yards per game. Sammy Brown leads the Clemson Tigers with 48 tackles, Will Heldt has 3.5 sacks and Ricardo Jones has 3 interceptions.
Why the Clemson Tigers will win
- Clemson has won 43 of its last 47 home games against non-AP-ranked teams.
- Clemson has covered the spread in seven of its last eight games as a home favorite against teams from North Carolina.
Why the Duke Blue Devils will win
- Duke has won eight of its last nine games against non-AP-ranked teams.
- Clemson has lost four of its last five home games.
- Clemson has failed to cover the spread in each of its last eight games at Memorial Stadium (Clemson).
- Duke has covered the spread in each of its last four road games against conference opponents.
- Duke has won the first half in six of its last eight games against conference opponents.
Total Points Facts
- Six of Duke’s last seven games as an underdog have gone OVER the total points line.
- Four of Clemson’s last five November games as a home favorite against non-AP-ranked teams have gone OVER the total points line.
Clemson Tigers Player Prop Facts
- Heading into Week 10, Avieon Terrell leads the Atlantic Coast Conference for forced fumbles (3) this season.
Duke Blue Devils Player Prop Facts
- Heading into Week 10, Vincent Anthony Jr. leads the Atlantic Coast Conference for sacks (6.5) this season.
Matchup/League Facts
- Clemson ranks 23rd among FBS teams for rushing yards allowed per game this season (109.7).
- Clemson ranks 113th among FBS teams for rushing yards per game this season (116.4).
- Duke ranks 13th among FBS teams for Q4 points per game this season (10.1).
- Duke ranks 18th among FBS teams for yards per game this season (463.3).
Duke vs Clemson Prediction
I’m not excited to back Duke, as this team is poorly coached and has some questionable performances, but Clemson in the favorite role is nuts. Clemson has been one of the biggest underachievers in college football. Clemson can’t run the ball, doesn’t finish drives, and you can pass on this defense. Duke is one of the best passing offenses in the country, so there should be some success there. Clemson is the more talented team and should be favored at home, but I’m not laying points with this group regardless. It’s Duke and the points or pass for me.
