Colorado vs West Virginia Prediction 11/8/2025 Today’s College Football Picks

The Colorado Buffaloes and the West Virginia Mountaineers meet in week 11 college football action from Milan Puksar Stadium on Saturday. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Colorado Buffaloes vs. West Virginia Mountaineers prediction.

Colorado Buffaloes Recap

The Colorado Buffaloes come into this game looking to rebound from a 52-17 loss at the hands of Arizona last time out to sit at 3-6 this season. After this game, Colorado will head home for a game against Arizona State following next week’s bye. 

Buffaloes Drop Back-To-Back Games

Kaidon Salter leads Colorado in passing with 1,242 yards, 10 touchdowns and 6 interceptions on 63.1% passing while also rushing for 293 yards and 5 TDs. Micah Welch leads Colorado in rushing with 313 yards and 2 touchdowns while Omarion Miller has 28 catches for 521 yards and 6 TDs and Joseph Williams has 386 receiving yards with 27 catches and 3 TDs. Tawfiq Byard leads Colorado’s defense with 63 total tackles including 46 solo tackles while the Buffaloes’ defense as a whole has combined for 10 sacks and 3 interceptions so far this season.

West Virginia Mountaineers Recap

The West Virginia Mountaineers come into this game looking to add on to their 45-35 win over Houston last time out to improve to 3-6 this season. After this game, West Virginia will head on the road for a game against Arizona State.

Mountaineers Snap Five-Game Slide

Nicco Marchiol has thrown for 720 yards, 2 touchdowns and 2 INTs on 67.3% passing while Scotty Fox Jr. has thrown for 620 yards, 4 touchdowns and 2 picks on 59.1% passing and Khalil Wilkins has thrown for 176 yards, a TD and 2 INTs on 48.4% passing while also rushing for 243 yards and 2 touchdowns. Diore Hubbard has a team-high 264 rushing yards and 4 touchdowns. Cam Vaughn leads West Virginia with 28 catches for 444 yards and 4 touchdowns while four more Mountaineers have 100+ receiving yards as well this season. On defense, Fred Perry leads West Virginia with 63 total tackles while Darrian Lewis and Chase Wilson each have 2 interceptions. As a unit, West Virginia’s defense has combined for 17 sacks and 10 interceptions this season.

Colorado Buffaloes @ West Virginia Mountaineers Betting Trends: Week 11

Why the West Virginia Mountaineers will win

• Colorado has lost each of its last 10 November games as an underdog.
• West Virginia has won each of its last six November games as a favorite.
• Colorado has failed to cover the spread in each of its last five games as an underdog against non-AP-ranked teams.
• West Virginia has covered the spread in each of its last five November games as a home favorite.
• Colorado has lost the first half in 14 of its last 17 road games against conference opponents.

Why the Colorado Buffaloes will win

• West Virginia has lost each of its last four games against non-AP-ranked teams.
• The underdog has covered the spread in three of West Virginia’s last four games.
• West Virginia has failed to cover the spread in three of its last four games against non-AP-ranked teams.
• West Virginia has lost the first half in six of its last seven games against conference opponents.

Total Points Facts

• Seven of West Virginia’s last eight games in November have gone OVER the total points line.
• Four of Colorado’s last five games against non-AP-ranked teams have gone OVER the total points line.

West Virginia Mountaineers Player Prop Facts

• Heading into Week 11, Darrian Lewis ranks T7th in the Big 12 Conference for interceptions (2) this season.

Colorado Buffaloes Player Prop Facts

• Heading into Week 11, Quentin Gibson ranks 3rd amongst FBS players for kick return yards (483) this season.

Matchup/League Facts

• West Virginia ranks T132nd among FBS teams for 3rd down conversion percentage this season (28.6).
• West Virginia ranks 130th among FBS teams for time of possession per game this season (26:46).
• Colorado ranks 134th among FBS teams for rushing yards allowed per game this season (215.8).
• Colorado ranks T131st among FBS teams for Q2 opponent points per game this season (11.9).

Colorado Buffaloes vs. West Virginia Mountaineers Prediction

I’m on West Virginia here. Colorado’s just been terrible defensively and going on the road hasn’t helped the Buffs, as they’re 0-3 SU/ATS, and lost by 16, 14 and 46 in their three road games this season. You can run on Colorado and that’s where West Virginia butters their bread and I think the Mountaineers pumel the Buffs here. Give me the Mountaineers.

Chris Ruffolo's Pick: West Virginia -6