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Clemson vs North Carolina Prediction 10/4/2025 Today’s College Football Picks
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Clemson (1-3) vs North Carolina (2-2)
October 4, 2025 at 12:00 PM EDT
The Line: Betting Odds: North Carolina +14 — Over/Under: +45.5
The Clemson Tigers and North Carolina Tar Heels meet Saturday in college football action at Kenan Stadium. Here’s a Clemson vs North Carolina Prediction. This article will include a Clemson vs North Carolina Pick.
The Clemson Tigers lost to Georgia Tech and Syracuse, and they play Boston College next. Clemson has lost 4 of its last 5 games. Cade Klubnik is completing 60.1 percent of his passes for 996 yards, 6 touchdowns, and 4 interceptions. Bryant Wesco Jr. and T.J. Moore have combined for 553 receiving yards and 5 touchdowns, while Tyler Brown has 13 receptions.
The Clemson Tigers ground game is averaging 116.3 yards per contest, and Adam Randall leads the way with 338 yards and 3 touchdowns. Defensively, Clemson is allowing 22.8 points and 362 yards per game. Wade Woodaz leads the Clemson Tigers with 35 tackles, Will Heldt has 3 sacks and Ronan Hanafin has 1 interception.
The North Carolina Tar Heels beat Richmond, lost to UCF, and they play Cal next. North Carolina has lost 5 of its last 7 games. Gio Lopez is completing 62.7 percent of his passes for 430 yards, 3 touchdowns, and 3 interceptions. Jordan Shipp and Chris Culliver have combined for 307 receiving yards and 3 touchdowns, while Javarius Green has 6 receptions.
The North Carolina Tar Heels ground game is averaging 113.5 yards per contest, and Demon June leads the way with 250 yards and 1 touchdown. Defensively, North Carolina is allowing 22.8 points and 344.5 yards per game. Andrew Simpson leads the North Carolina Tar Heels with 28 tackles, Melkart Abou Jaoude has 2 sacks and Malcolm Ziglar has 1 interception.
I know North Carolina isn’t a good team, as it’s led by one of the worst offenses in the country and has a head coach who may have watched the game pass him by. However, what in the world has Clemson done to deserve to be a double-digit favorite on the road? Clemson has 3 ugly losses and didn’t look convincing in its lone win against Troy. Clemson has underachieved on other sides of the ball and can’t be trusted at the moment. This line feels like oddsmakers haven’t been watching football this season. Clemson has also failed to cover each of its last 6 games as a double-digit favorite, and 2 of those games were outright losses. I’m going to grab the points with North Carolina at home.
Clemson Tigers Betting Preview
The Clemson Tigers lost to Georgia Tech and Syracuse, and they play Boston College next. Clemson has lost 4 of its last 5 games. Cade Klubnik is completing 60.1 percent of his passes for 996 yards, 6 touchdowns, and 4 interceptions. Bryant Wesco Jr. and T.J. Moore have combined for 553 receiving yards and 5 touchdowns, while Tyler Brown has 13 receptions.
The Clemson Tigers ground game is averaging 116.3 yards per contest, and Adam Randall leads the way with 338 yards and 3 touchdowns. Defensively, Clemson is allowing 22.8 points and 362 yards per game. Wade Woodaz leads the Clemson Tigers with 35 tackles, Will Heldt has 3 sacks and Ronan Hanafin has 1 interception.
North Carolina Tar Heels Betting Preview
The North Carolina Tar Heels beat Richmond, lost to UCF, and they play Cal next. North Carolina has lost 5 of its last 7 games. Gio Lopez is completing 62.7 percent of his passes for 430 yards, 3 touchdowns, and 3 interceptions. Jordan Shipp and Chris Culliver have combined for 307 receiving yards and 3 touchdowns, while Javarius Green has 6 receptions.
The North Carolina Tar Heels ground game is averaging 113.5 yards per contest, and Demon June leads the way with 250 yards and 1 touchdown. Defensively, North Carolina is allowing 22.8 points and 344.5 yards per game. Andrew Simpson leads the North Carolina Tar Heels with 28 tackles, Melkart Abou Jaoude has 2 sacks and Malcolm Ziglar has 1 interception.
Clemson Tigers @ North Carolina Tar Heels Betting Trends: Week 6
Why the North Carolina Tar Heels will win
- Clemson has lost four of its last five games.
- Clemson has failed to cover the spread in nine of its last 10 games as a favorite.
- The underdog has covered the spread in each of Clemson’s last four games.
Why the Clemson Tigers will win
- Clemson has won 33 of its last 36 games against teams from North Carolina.
- North Carolina has lost four of its last five games in October.
- North Carolina has failed to cover the spread in each of its last six games against conference opponents at Kenan Stadium.
- Clemson has covered the spread in each of its last four games against teams from North Carolina.
Total Points Facts
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- Each of Clemson’s last five road games against non-AP-ranked teams have gone UNDER the total points line.
- Each of North Carolina’s last four games as an underdog against teams from South Carolina have gone UNDER the total points line.
North Carolina Tar Heels Player Prop Facts
- Heading into Week 6, Jordan Shipp leads North Carolina for touchdowns (2) this season.
Clemson Tigers Player Prop Facts
- Heading into Week 6, Bryant Wesco Jr. leads the Atlantic Coast Conference for receiving touchdowns (5) this season.
Matchup/League Facts
- North Carolina ranks 9th among FBS teams for red zone percentage against this season (64.7).
- North Carolina ranks 125th among FBS teams for time of possession per game this season (26:26).
- Clemson ranks 123rd among FBS teams for H1 points per game this season (8.5).
- Clemson ranks 116th among FBS teams for points per game this season (19.8).
Clemson vs North Carolina Prediction
I know North Carolina isn’t a good team, as it’s led by one of the worst offenses in the country and has a head coach who may have watched the game pass him by. However, what in the world has Clemson done to deserve to be a double-digit favorite on the road? Clemson has 3 ugly losses and didn’t look convincing in its lone win against Troy. Clemson has underachieved on other sides of the ball and can’t be trusted at the moment. This line feels like oddsmakers haven’t been watching football this season. Clemson has also failed to cover each of its last 6 games as a double-digit favorite, and 2 of those games were outright losses. I’m going to grab the points with North Carolina at home.
