Clemson vs Louisville Prediction 11/14/2025 Today’s College Football Picks

The Clemson Tigers and Louisville Cardinals meet Friday in college football action at L&N Federal Credit Union Stadium. Here’s a Clemson vs Louisville Prediction. This article will include a Clemson vs Louisville Pick.

Clemson Tigers Betting Preview

The Clemson Tigers lost to Duke, beat Florida State, and they play Furman next. Clemson has lost 4 of its last 7 games. Cade Klubnik is completing 67.9 percent of his passes for 2,136 yards, 14 touchdowns, and 5 interceptions. Bryant Wesco Jr. and T.J. Moore have combined for 1,073 receiving yards and 10 touchdowns, while Antonio Williams has 39 receptions.

The Clemson Tigers ground game is averaging 120.9 yards per contest, and Adam Randall leads the way with 570 yards and 6 touchdowns. Defensively, Clemson is allowing 22.4 points and 351.3 yards per game. Sammy Brown leads the Clemson Tigers with 67 tackles, Will Heldt has 5 sacks and Ricardo Jones has 4 interceptions.

Louisville Cardinals Betting Preview

The Louisville Cardinals beat Virginia Tech, lost to Cal, and they play SMU next. Louisville has won 10 of its last 12 games. Miller Moss is completing 63.8 percent of his passes for 2,132 yards, 11 touchdowns, and 7 interceptions. Chris Bell and Caullin Lacy have combined for 1,274 receiving yards and 8 touchdowns, while Jaleel Skinner has 15 receptions.

The Louisville Cardinals ground game is averaging 174.3 yards per contest, and Isaac Brown leads the way with 782 yards and 5 touchdowns. Defensively, Louisville is allowing 24.4 points and 333.9 yards per game. TJ Quinn leads the Louisville Cardinals with 67 tackles, Wesley Bailey has 5 sacks and Antonio Watts has 3 interceptions.

Louisville Cardinals Player Prop Facts

• Heading into Week 12, Isaac Brown leads the league for yards per carry (8.6) this season.

Clemson Tigers Player Prop Facts

• Heading into Week 12, Adam Randall is one of only eight players in the FBS to record 3+ rushing and 3+ receiving TDs this season.

Matchup/League Facts

• Louisville ranks 10th among FBS teams for 1st downs against this season (143).
• Louisville ranks 13th among FBS teams for yards allowed per game this season (296.8).
• Clemson ranks T22nd among FBS teams for Q3 opponent points per game this season (3.4).
• Clemson ranks 112th among FBS teams for rushing yards per game this season (120.9).

Clemson vs Louisville Prediction

Clemson got a nice win over Florida State to keep its bowl hopes alive, but that doesn’t mean everything is fine. Clemson is still an underachieving team that can’t run the ball offensively and can’t stop the pass. Clemson is 3-6 ATS on the season and hasn’t been able to string together winning performances. Louisville has the more explosive offense and despite two losses, both games were decided in overtime. A bounce here or a bounce there, and Louisville is undefeated and looking at a playoff spot. There’s no reason to get behind Clemson, especially with a soft line. Give me Louisville by a touchdown on Friday night.

Randy Chambers's Pick: Louisville -3