Buffalo vs Central Michigan Prediction 11/12/2025 Today’s College Football Picks

The Buffalo Bulls and the Central Michigan Chippewas meet in week 12 college football action from Kelly/Shorts Stadium on Wednesday. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Buffalo Bulls vs. Central Michigan Chippewas prediction.

Buffalo Bulls Recap

The Buffalo Bulls come into this game looking to build on a 28-3 win over Bowling Green last time out to improve to 5-4 this season. After this game, Buffalo will head home for a game against Miami-Ohio.

Bulls Win 3 Of Last 4

Ta’Quan Roberson has thrown for 1,739 yards, 12 touchdowns and 8 interceptions on 60.5% passing while Gunnar Gray has thrown for 174 yards, a touchdown and an interception on 52.3% passing while Al-Jay Henderson has rushed for 663 yards and 5 touchdowns and Lamar Sperling has 202 rushing yards and a TD as well. Nik McMillan has a team-high 590 receiving yards coming on 42 catches with a touchdown while Victor Snow has 586 receiving yards with 7 TDs and a team-high 45 catches. Jasaiah Gathings has 274 receiving yards and a touchdown as well for the Bulls. On defense, Red Murdock has a team-high 105 total tackles and 4.5 sacks while Junior Poyser also has a team-high 4.5 sacks. As a unit, Buffalo’s defense has combined for 33 sacks and 4 interceptions so far this season.

Central Michigan Chippewas Recap

The Central Michigan Chippewas come into this game looking to bounce back from a 24-21 loss at the hands of Western Michigan last time out to sit at 5-4 this season. After this game, Central Michigan will head on the road for a game against Kent State.

Chippewas Have Two-Game Win Streak Snapped

Joe Labas has thrown for 1,066 yards, 8 touchdowns and 2 interceptions on 71.6% passing while Angel Flores leads the Chippewas in rushing with 519 yards and 8 TDs and Nahree Biggins have 426 rushing yards and 2 TDs. Trey Cornist has 299 rushing yards and a TD and Brock Townsend has 288 rushing yards with 2 TDs as well. Langston Lewis has 21 catches for 295 yards and 2 TDs while Tommy McIntosh has 225 receiving yards. Three more Chippewas have 100+ receiving yards as well on the year. On defense, Jordan Kwiatkowski has a team-high 70 total tackles and a pair of interceptions while Michael Heidman has a team-high 5.5 sacks as well this season. As a unit, Central Michigan’s defense has combined for 16 sacks and 10 interceptions so far this season. 

Buffalo Bulls @ Central Michigan Chippewas Betting Trends: Week 12

Why the Central Michigan Chippewas will win

• Central Michigan has won each of its last nine games as a home favorite.
• Central Michigan has covered the spread in each of its last six home games.
• Buffalo has failed to cover the spread in six of its last seven games.
• Central Michigan has won the first quarter in four of its last five games against conference opponents.
• Central Michigan has won the first half in four of its last five games against conference opponents.

Why the Buffalo Bulls will win

• Buffalo has won each of its last three November games as an underdog.
• Central Michigan has lost nine of its last 10 games in November.
• Buffalo has covered the spread in each of its last four games as a road underdog.
• Buffalo has won the first quarter in four of its last five road games against conference opponents.

Total Points Facts

• Each of Central Michigan’s last five home games against teams from New York have gone OVER the total points line.
• Six of Buffalo’s last seven games in Michigan have gone OVER the total points line.

Central Michigan Chippewas Player Prop Facts

• Heading into Week 12, Angel Flores ranks T2nd in the Mid-American Conference for rushing touchdowns (8) this season.

Buffalo Bulls Player Prop Facts

• Heading into Week 12, Nik McMillan is one of only three players in the FBS to record 100+ receiving yards in three or more consecutive games this season.

Matchup/League Facts

• Central Michigan ranks 135th among FBS teams for Q4 points per game this season (2.4).
• Central Michigan ranks 127th among FBS teams for H2 points per game this season (7.8).
• Buffalo ranks 5th among FBS teams for Q1 opponent points per game this season (1.9).
• Buffalo ranks 9th among FBS teams for H1 opponent points per game this season (6.9).

Buffalo Bulls vs. Central Michigan Chippewas Prediction

I’m on Central Michigan here. I could easily make the case that Buffalo could be winless in MAC play if they didn’t get a couple of bounces, and I’ve sold my stock on this Buffalo team as I’m simply not a believer. Central Michigan is still a solid squad, especially at home, and I think they get the win at home here. Give me Central Michigan in this one.

Chris Ruffolo's Pick: Central Michigan -1.5