Sep 13, 2025; Oxford, Mississippi, USA; Arkansas Razorback quarterback Taylen Green (10) drops back to pass during the first quarter against the Mississippi Rebels at Vaught-Hemingway Stadium. Mandatory Credit: Petre Thomas-Imagn Images

Arkansas vs Memphis Prediction 9/20/2025 Today’s College Football Picks

Pick details

Arkansas (2-1) vs Memphis (3-0)

September 20, 2025 at 12:00 PM EDT

The Line: Betting Odds: Memphis +7.5 — Over/Under: +62.5

(Get latest betting odds)

Arkansas and Memphis meet Saturday in Week 4 college football action from Liberty Bowl Memorial Stadium. Here’s a Arkansas vs Memphis prediction. We will look at this from a betting perspective and determine the best Memphis Tigers vs Arkansas Razorbacks pick. We will examine:

The Arkansas Razorbacks’ recent form and player performance

The Memphis Tigers’’ recent form and player performance

Recent betting trends and streaks involving the Razorbacks’

Recent betting trends and streaks involving the Tigers

Recent betting trends in games played between Memphis and Arkansas

A summary that ties it all together and produces a favorable betting outcome for the Arkansas and Memphis game.

How Does Arkansas Bounce Back?

Arkansas might have lost the last game against Ole Miss, but there actually were some positives that could be taken away from that game, especially on the offensive side of the ball. The Arkansas offense scored 35 points, including 21 in the second period. Arkansas actually outgained Ole Miss 526-475. Quarterback Taylen Green completed 22 of his 35 passes for 305 yards, one touchdown, and zero interceptions. He also ahd a huge game on the ground rushing 14 times for 115 yards and a touchdown. Arkansas obviously needs a better defense, but they have to be happy with the way the offense stepped up. 

Arkansas on the season is averaging 47.67 runs while their defense is giving up 20.67 runs per game. The offense is ranked 11th in all of college football, while the defense is ranked 65th. Green on the season has thrown for 866 yards, 11 touchdowns, and two interceptions. He has also rushed for 307 yards and two touchdowns. 

Why Arkansas Will Beat Memphis

  • The favorite has won 17 of Memphis’ last 18 games at Simmons Bank Liberty Stadium.
  • Memphis has failed to cover the spread in seven of its last eight September games at Simmons Bank Liberty Stadium.
  • Arkansas has covered the spread in each of its last four games in Tennessee.
  • Memphis has lost the first half in each of its last three games against opponents from the Southeastern Conference.

Strong Start for Memphis 

It has been a strong season so far for Memphis, and they come into this game with a perfect 3-0 record. Two games ago, against Georgia State they were able to secure the 38-16 victory, and in the last game against Troy, they were able to pick up the 28-7 victory. At halftime against Troy, they were up able to pick up the 21-7 and they never looked back on the way to the victory. Brendon Lewis is under center for Troy and he completed 17 of his 27 passes for 213 yards , one touchdown, and zero interceptions. Sutton Smith was a star on the ground and he finished with 18 carries for 113 yards and two touchdowns. 

Memphis on the season is averaging 37 points while their defense is giving up 11 points per game. The offense is ranked 41st while the defense is ranked 11th. On the season, Lewis has thrown for 608 yards, two touchdowns, and one interception. 

Why Memphis Will Beat Arkansas

  • Memphis has won each of its last 10 games against non-conference opponents at Simmons Bank Liberty Stadium.
  • Memphis has covered the spread in eight of its last nine games against non-conference opponents.
  • Arkansas has failed to cover the spread in three of its last four September games as a favorite against non-AP-ranked teams.

Arkansas vs Memphis Prediction 


Give me Memphis here. Is Memphis the better team in this matchup? I don’t think so, but Memphis is getting way too many points here. Taylen Green is good, but the way the Arkansas defense looked in the last game, I expect they are going to really struggle here. Memphis has a really good quarterback in Lewis, and he’s going to have no issue running up the score against this Arkansas defense. Arkansas still probably wins this game, but Memphis is going to keep this game close. Back Memphis to cover the spread.

Shane Mickle's Pick: Memphis +7.5

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