Arizona vs Colorado Prediction 11/1/2025 Today’s College Football Picks

The Arizona Wildcats and the Colorado Buffaloes meet in week 10 college football action from Folsom Field on Saturday. We will look at this from a betting perspective and determine the best bets for this game. Here’s an Arizona Wildcats vs. Colorado Buffaloes prediction.

Arizona Wildcats Recap

The Arizona Wildcats come into this game looking to bounce back from a 31-28 loss at the hands of Houston last time out to slide to 4-3 this season. After this game, Arizona will head home for a game against the Kansas Jayhawks.

Wildcats Drop Back-To-Back Games

Noah Fifita leads Arizona in passing with 1,829 yards, 17 touchdowns and 4 interceptions on 66% passing while Ismail Mahdi leads Arizona in rushing with 445 rushing yards and a touchdown this season. Javin Whatley leads Arizona’s receiving group with 32 grabs for 370 yards and 3 touchdowns while Kris Hutson’s added 24 catches for 318 yards and 2 TDs. On defense, Dalton Johnson has a team-high 52 total tackles while Riley Wilson has a team-high 3 sacks. As a unit, Arizona’s defense has combined for 14 sacks and 9 interceptions so far this season.

Colorado Buffaloes Recap

The Colorado Buffaloes will be out to bounce back from a 53-7 loss at the hands of Utah in their last game to slip to 3-5 this season. After this game, Colorado will head on the road for a game against West Virginia.

Buffaloes Drop 3 Of Last 4

Kaidon Salter leads Colorado in passing with 1,193 yards, 9 touchdowns and 5 interceptions on 62.2% passing while also rushing for 266 yards and 5 TDs. Micah Welch leads Colorado in rushing with 281 yards and 2 touchdowns while Omarion Miller has 23 catches for 430 yards and 4 TDs and Joseph Williams has 370 receiving yards with a team-high 24 catches and 3 TDs. Tawfiq Byard leads Colorado’s defense with 57 total tackles including 41 solo tackles while the Buffaloes’ defense as a whole has combined for 9 sacks and 3 interceptions so far this season.

Arizona Wildcats @ Colorado Buffaloes Betting Trends: Week 10

Why the Colorado Buffaloes will win

• Colorado has won each of its last nine November home games against non-AP-ranked teams.
• Arizona has lost each of its last five road games.
• Colorado has covered the spread in each of its last nine games against conference opponents at Folsom Field.
• Arizona has failed to cover the spread in seven of its last eight November road games against non-AP-ranked teams.
• Arizona has lost the first half in each of its last five road games against conference opponents.
• Colorado has won the first quarter in seven of its last eight games against conference opponents at Folsom Field.

Why the Arizona Wildcats will win

• Colorado has lost each of its last nine November games as an underdog.
• The favorite has won 12 of Colorado’s last 13 games at Folsom Field.
• Colorado has failed to cover the spread in each of its last four games as an underdog against non-AP-ranked teams.
• The favorite has covered the spread in nine of Arizona’s last 11 games.

Total Points Facts

• Nine of Colorado’s last 10 games as an underdog against teams from Arizona have gone OVER the total points line.
• Each of Arizona’s last five road games have gone OVER the total points line.

Colorado Buffaloes Player Prop Facts

• Heading into Week 10, Quentin Gibson ranks 3rd amongst FBS players for kick return yards (483) this season.

Arizona Wildcats Player Prop Facts

• Heading into Week 10, Tre Spivey leads Arizona for touchdowns (6) this season.

Matchup/League Facts

• Colorado ranks 134th among FBS teams for rushing yards allowed per game this season (217.3).
• Colorado ranks T123rd among FBS teams for 1st downs against this season (184).
• Arizona ranks T7th among FBS teams for Q1 points per game this season (10.4).
• Arizona ranks 9th among FBS teams for passing yards allowed per game this season (153.1).

Arizona Wildcats vs. Colorado Buffaloes Prediction

I’m on Colorado and the points here. I think last week’s drubbing at the hands of Utah left a bad taste in Colorado and Coach Prime’s mouth and it wouldn’t surprise me to see them bounce back here. Arizona has been in some close ones as well as of late, and this is a Colorado team that’s usually solid as an underdog and a home underdog as well. I’ll take my chances with Colorado and the points here.