Notre Dame (3-1) vs Louisville (3-0)
Game Info: Saturday, September 28, 2024 at 3:30 pm (Notre Dame Stadium)
Betting Odds: Notre Dame -6 / Louisville +6 --- Over/Under: 48.5 Click Here for the Latest Odds
Where to Watch: Peacock Stream live sports and exclusive originals on ESPN+. Sign up now! 
The Louisville Cardinals and the Notre Dame Fighting Irish meet in week 5 college football action from Notre Dame Stadium on Saturday afternoon. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Louisville vs. Notre Dame prediction.
Louisville Recap
The Louisville Cardinals come into this one looking to build on their 3-0 start to the year after taking out Georgia last time out by a final score of 31-19. After this game, Louisville will head back home for a matchup with SMU.
Cardinals Hoping To Sustain Success In First True Road Game
Tyler Shough has thrown for 850 yards and 8 touchdowns on 68.4% passing while Isaac Brown has rushed for a team-high 173 yards. Duke Watson and Keyjuan Brown each have 100+ rushing yards as well while Ja’Corey Brooks has a team-high 17 receptions for 297 yards and Chris Bell has 6 grabs for 167 yards as well on the year. On defense, TJ Quinn and Stanquan Clark each have a team-high 14 total tackles while Tramel Logan has 3 sacks to lead Louisville, and Tamarion McDonald and Jared Dawson each have 2 sacks.
Why the Louisville Cardinals will win
- Louisville has won each of its last eight games in September.
- The road team has covered the spread in each of Notre Dame's last four games.
- Notre Dame has failed to cover the spread in each of its last four home games in September.
Notre Dame Recap
The Notre Dame Fighting Irish come into this game hoping to build on back-to-back wins after a 28-3 win over Miami-Ohio in their last matchup to improve to 3-1 on the year. After this game, Notre Dame will welcome Stanford to town.
Irish Hoping To Keep Defensive Pressure Up
Riley Leonard has thrown for 587 yards, a touchdown, and 2 interceptions on 63.1% passing while also rushing for 322 yards and 6 touchdowns on the ground. Jeremiyah Love has a team-high 339 rushing yards and 4 touchdowns while Jadarian Price has 193 rushing yards and 2 TDs. Beaux Collins has a team-high 16 receptions for 176 yards as well to lead Notre Dame’s receivers. On defense, Jack Kiser has a team-high 22 total tackles including 13 solo tackles while the Irish defense as a whole has combined for 9 sacks and 6 interceptions as well on the year.
Why the Notre Dame Fighting Irish will win
- Notre Dame has won each of its last 18 games against opponents from the Atlantic Coast Conference at Notre Dame Stadium.
- Louisville has lost each of its last five September games against AP-ranked teams.
- Notre Dame has covered the spread in 12 of its last 13 games as a favorite against AP-ranked teams.
- Louisville has failed to cover the spread in four of its last five September games against AP-ranked teams.
Louisville vs. Notre Dame Prediction
I’m on the Cardinals and the points here. I just think this ends up being a 3-4 point game as Louisville’s defense is solid and while they’ve played a bit of a soft schedule, I still think there’s a lot to like with an experienced QB like Shough leading this Louisville offense. I also think the Cardinals have a coaching edge here as I’m still not really sold on Marcus Freeman with Notre Dame. Give me the Cardinals and the points.
Chris’s Pick Louisville +6
AUTHOR: Chris Ruffolo
Mitch's Take...
