San Diego FC vs Seattle Sounders 5/28/25 Prediction MLS Picks

San Diego FC will visit Seattle Sounders on Wednesday, May 28th, 2025, at the Lumen Field in this Week 16 Major League Soccer matchup. We will look at this from a betting perspective and determine the best bets for this game. Here’s a San Diego FC vs Seattle Sounders Prediction. We will examine:

Seattle Sounders recent form and player performance

San Diego FC recent form and player performance

Recent betting trends and streaks involving Seattle Sounders 

Recent betting trends and streaks involving San Diego FC

Recent betting trends in games played between the San Diego FC and Seattle Sounders 

A summary that ties it all together and produces a favorable betting outcome for San Diego FC vs Austin FC game

Seattle Sounders Preview

Seattle has 23 points this season and are tied with two more teams on the 4th place of the Western Conference. Seattle has a 6-4-5 record, and have a 4-0-2 home record. Seattle is coming off a 1-0 home victory over Dallas, and have only one loss in their last 8 games. Both teams to score – No is 3-1 in their last 4 home games.  

Seattle is averaging 1.47 goals per game, which is the tied for 7th in the West, while allowing 1.27 goals per game, which is 5th-best in the conference. Albert Rusnák is the top scorer for Seattle this season with 7 total goals.

San Diego FC Preview

San Diego has 27 points this season and sitting on the second place of the Western Conference. San Diego has an 8-4-3 record this season, and are 3-3 on the road. San Diego is coming off a 2-1 home victory over the LA Galaxy, and have been undefeated in their last five games, with four wins and one draw. They are 1-3 in their last four road games, and over is 5-0 in their last 5 games on the road.

San Diego is averaging 1.80 goals per game, which is the tied for second-best in the West, while allowing 1.13 goals per game, which is tied for third-best in the conference. Anders Dreyer is the top scorer for San Diego this season with 6 total goals.

Why Seattle Sounders will win

• Seattle has won four of its last five MLS home games.
• Seattle has won each of its last three MLS games as a home favorite.
• San Diego FC has lost three of its last four MLS away games.
• The home team has won eight of San Diego FC’s last 11 MLS games.
• The favorite has won four of Seattle’s last five MLS games.
• The favorite has won four of Seattle’s last five MLS games at Lumen Field.

Why San Diego FC will win

• San Diego FC has won four of its last five MLS games.

Total Points Facts

• The ‘Both Teams to Score’ market has hit in four of San Diego FC’s last five MLS away games.
• The ‘Both Teams to Score’ market has hit in four of Seattle’s last five MLS games as a favorite.
• The ‘Over 2.5 Goals’ market has hit in each of San Diego FC’s last five MLS away games.
• The ‘Over 2.5 Goals’ market has hit in nine of San Diego FC’s last 11 MLS games.

San Diego FC vs Seattle Sounders Prediction

In their only previous meeting earlier this season, San Diego won 3-0 at home. In this San Diego FC vs Seattle Sounders Prediction, Seattle is coming as -130 home favorites. San Diego has more points than Seattle, but Seattle has been undefeated at home, so that is why there are favorited in that spot. Both teams have been in excellent form lately, as Seattle has lost only once in their last 8 games and San Diego is undefeated in its last five. This looks very balanced from a side perspective, so I will pass on the side. Both teams have been scoring consistently, and they have top-7 offenses this season, so I really like the Both teams to score – Yes in this one.

Nikos Lagouretos's Pick: Both teams to score – Yes