Seattle Seahawks vs San Francisco 49ers Prediction 1/3/2026 Today’s NFL Picks

The Seattle Seahawks and the San Francisco 49ers meet in week 18 NFL action from Levi’s Stadium on Saturday. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Seattle Seahawks vs. San Francisco 49ers prediction.

Seattle Seahawks Recap

The Seattle Seahawks come into this game looking to add on to their 27-10 win over Carolina last time out to sit at 13-3 this season.

Seahawks Looking To Secure Division & 1-seed

Sam Darnold has thrown for 3,850 yards, 25 touchdowns and 14 interceptions on 67.2% passing while Kenneth Walker III has 930 rushing yards with 5 touchdowns to lead Seattle and Zach Charbonnet has 656 rushing yards with 11 touchdowns. Jaxon Smith-Njigba leads the Seahawks in receiving with 113 catches for 1,709 yards and 10 touchdowns while Cooper Kupp has 564 receiving yards and AJ Barner has 505 receiving yards with 6 TDs. On defense, Ernest Jones IV leads the Seahawks with 121 total tackles along with 5 interceptions while Leonard Williams and Byron Murphy II each have a team-high 7 sacks. Uchenna Nwosu has 6 sacks and DeMarcus Lawrence also has 6 sacks. As a unit, Seattle’s defense has combined for 44 sacks and 17 interceptions so far this season.

San Francisco 49ers Recap

The San Francisco 49ers come into this game looking to add on to their 42-38 win over Chicago last time out to sit at 12-4 this season.

49ers Trying To Steal Division & Home Field

Mac Jones has thrown for 2,151 yards, 13 touchdowns and 6 interceptions on 69.6% passing while Brock Purdy has thrown for 2,040 yards, 20 touchdowns and 9 interceptions on 69.3% passing. Christian McCaffrey has a team-high 1,179 rushing yards and 10 TDs while also leading the 49ers in receiving with 96 grabs for 890 yards and 7 touchdowns. Ricky Pearsall has 528 receiving yards and 36 receptions while Kendrick Bourne has 551 receiving yards and Jauan Jennings has 608 receiving yards and 9 TDs. George Kittle also has 599 receiving yards and 52 catches along with 7 touchdowns this season. Three more 49ers have 200+ receiving yards as well on the year. On defense, Dee Winters has a team-high 99 total tackles. Bryce Huff and Clelin Ferrell each have a team-high 4 sacks. As a unit, San Francisco’s defense has combined for 18 sacks and 6 interceptions so far this season. 

Seattle Seahawks @ San Francisco 49ers Betting Trends: Week 18

Why the San Francisco 49ers will win

• The 49ers have won each of their last six games without Brandon Aiyuk.
• The Seahawks have lost three of their last four games at Levi’s Stadium.
• The Seahawks have failed to cover the spread in each of their last six January games as favorites against NFC West opponents.
• The 49ers have covered the spread in five of their last six January games as underdogs against NFC West opponents.
• The 49ers have scored the first touchdown in each of their last eight games against the Seahawks.
• The 49ers have won the first quarter in 12 of their last 13 home games following a home win.
• The 49ers have won the first half in each of their last six games.

Why the Seattle Seahawks will win

• The Seahawks have won each of their last nine games as slight favorites (<-3.5 points).
• The 49ers have lost each of their last five games without Kendrick Bourne.
• The 49ers have failed to cover the spread in 14 of their last 15 home games following a win.
• The Seahawks have covered the spread in seven of their last eight road games.
• The Seahawks have scored the first touchdown in each of their last six games as favorites against NFC West opponents.
• The Seahawks have won the first quarter in each of their last two games against teams that held a winning record.
• The favorites have won the first half in each of the 49ers’ last nine games.

Total Points Facts

• Seven of the 49ers’ last eight January games against NFC West opponents have gone OVER the total points line.
• Seven of the Seahawks’ last eight games as road favorites following a road win have gone UNDER the total points line.
• Six of the last seven games between NFC West teams have gone OVER the total points line.

San Francisco 49ers Player Prop Facts

• Jauan Jennings has scored at least one touchdown in each of the 49ers’ last six games following a win.
• Brock Purdy has recorded 244+ passing yards in 12 of his last 15 home appearances against NFC opponents.
• Brock Purdy has recorded 23+ completions in four of the 49ers’ last five games.
• Kendrick Bourne has recorded 19+ rushing and receiving yards in each of his last eight appearances with his team as an underdog following a win.
• Kendrick Bourne has recorded 16+ receiving yards in each of his last nine appearances with his team as an underdog against NFC West opponents.
• Brian Robinson has recorded 24+ rushing yards in each of his last 10 appearances with his team as a home underdog.
• Heading into Week 18, Brock Purdy has recorded the equal-most passing touchdowns in a single game this season (5 vs Colts, Week 16).

Seattle Seahawks Player Prop Facts

• Zach Charbonnet has scored at least one touchdown in six of the Seahawks’ last seven games played as favorites on the West Coast.
• Sam Darnold has recorded 22+ completions in three of his last four road appearances against NFC West opponents.
• Zach Charbonnet has recorded 12+ receiving yards in six of the Seahawks’ last seven games as road favorites against NFC opponents.
• Kenneth Walker III has recorded 67+ rushing and receiving yards in each of his last seven appearances with the Seahawks as favorites against NFC West opponents.
• Sam Darnold has recorded 249+ passing yards in three of the Seahawks’ last four games.
• Kenneth Walker III has recorded 64+ rushing yards in each of his last seven appearances with the Seahawks as favorites against NFC West opponents.
• Heading into Week 18, Jason Myers ranks 1st in the NFL in made field goals (39) this season.

Matchup/League Facts

• Heading into Week 18, the 49ers rank 32nd in the NFL in sacks (18.0) this season.
• Heading into Week 18, the 49ers rank 32nd in the NFL in total punt yards (1738) this season.
• Seahawks – two different players have recorded 80+ rushing yards in a game this season – equal-most in the NFL, heading into Week 18.
• Seahawks – two different players have recorded 90+ rushing yards in a game this season – equal-most in the NFL, heading into Week 18.

Seattle Seahawks vs. San Francisco 49ers Prediction

I’m leaning towards Seattle here. This might be a better game to watch because both teams are in great form, but in all honesty, San Francisco’s offense has done well against bad defenses as of late and Seattle’s defense is really solid this season. On the other side, Seattle has been great on the road and the Seahawks face a 49ers’ defense that hasn’t been drumming up sacks compared to past teams. I think Seattle gets another road win and wins the division here. Give me the Seahawks.

Chris Ruffolo's Pick: Seattle -1.5