Los Angeles Rams vs Tennessee Titans Prediction 9/14/2025 Today’s NFL Picks

The Los Angeles Rams and the Tennessee Titans meet in week 2 NFL action from Nissan Stadium on Sunday. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Los Angeles Rams vs. Tennessee Titans prediction.

Los Angeles Rams Recap

The Los Angeles Rams come into this game looking to add on to their season-opening 14-9 win over the Houston Texans to start the year 1-0. After this game, the Rams will head on the road for a game against the Philadelphia Eagles.

Rams Looking For Strong Start To Season

Matthew Stafford threw for 245 yards and a touchdown on 21 of 29 passing while Kyren Williams rushed for 66 yards and a touchdown. Puka Nacua led the Rams’ receiving group with 10 catches for 130 yards while Davante Adams had 4 catches for 51 yards and Davis Allen recorded the Rams’ lone receiving TD in the win. On defense, Kam Curl and Nate Landman each had a team-high 10 total tackles, while Byron Young, Tyler Davis and Jaylen McCollough each had a sack and Cobie Durant chipped in an interception for hte Rams defensively in the win.

Tennessee Titans Recap

The Tennessee Titans come into this game looking to rebound from their 20-12 loss at the hands of the Denver Broncos last time out to start the year at 0-1. After this game, the Titans will head home for a game against the Indianapolis Colts.

Titans Looking To Shake Off Opening Loss

Cam Ward threw for 112 yards on 12 of 28 pastting while Tony Pollard led the Titans on the ground with 60 rushing yards on 18 carries. Pollard led the Titans with 29 receiving yards while Calvin Ridley had a team-high 4 receptions for 27 yards and Chig Okonkwo added 3 receptions for 19 yards as well. On defense, Jarvis Brownlee Jr. and Cody Barton each had a team-high 9 total tackles with Brownlee Jr. adding 6 solo tackles while Jeffery Simmons had a sack. Xavier Woods and Roger McCreary each had an interception as well for Tennessee in the defeat. 

Los Angeles Rams @ Tennessee Titans Betting Trends: Week 2

Why the Tennessee Titans will win

• The Titans have won four of their last five September games as home underdogs.
• The Rams have lost each of their last four road games in September.
• The Rams have failed to cover the spread in each of their last four road games in September.
• The Titans have covered the spread in five of their last six September games as underdogs against NFC opponents.
• The Rams have lost the first quarter in each of their last four road games against teams that held a losing record.
• The Rams have lost the first half in nine of their last 10 Sunday road games.
• The Titans have scored the first touchdown in six of their last seven games as home underdogs.

Why the Los Angeles Rams will win

• The Rams have won each of their last 11 Sunday games as favorites.
• The Titans have lost each of their last seven games.
• The Titans have failed to cover the spread in each of their last eight home games.
• The Rams have covered the spread in each of their last six road games.
• The Rams have won the first half in each of their last eight games as moderate favorites (-3.5 to -7.0 points).
• The Rams have scored the first touchdown in six of their last seven games against AFC South opponents.
• The Rams have won the first quarter in each of their last seven road games against AFC South opponents.

Total Points Facts

• Seven of the Rams’ last eight games as favorites have gone UNDER the total points line.
• Eight of the Titans’ last 10 games as underdogs have gone OVER the total points line.

Tennessee Titans Player Prop Facts

• Calvin Ridley has scored at least one touchdown in five of his six previous Week 2 appearances.
• Tony Pollard has recorded 70+ rushing yards in four of his last five September appearances against NFC opponents.
• Calvin Ridley has recorded 58+ receiving yards in each of the Titans’ last seven games following a road loss.
• Calvin Ridley has recorded 58+ rushing and receiving yards in each of the Titans’ last seven games following a road loss.
• Heading into Week 2, Joey Slye ranks T1st in the NFL in made field goals (4) this season.

Los Angeles Rams Player Prop Facts

• Kyren Williams has scored the first touchdown in four of his last five Sunday regular season appearances.
• Matthew Stafford has recorded 240+ passing yards in each of his 15 previous September appearances against AFC opponents.
• Puka Nacua has recorded 84+ receiving yards in eight of his last nine appearances against AFC opponents.
• Kyren Williams has recorded 87+ rushing yards in eight of his last nine appearances following a home win.
• Kyren Williams has scored at least one touchdown in 10 of his last 11 appearances in day games against teams with a losing record.
• Kyren Williams has recorded 95+ rushing and receiving yards in each of his last nine appearances following a home win.
• Matthew Stafford has recorded 22+ completions in each of his four previous appearances against the Titans.
• Heading into Week 2, Puka Nacua ranks T1st in the NFL in receptions (10) this season.

Matchup/League Facts

• Titans – two different players have recorded one interception or more in a game this season – equal-most in the NFL, heading into Week 2.
• Heading into Week 2, the Titans rank 32nd in the NFL in yards per game (133.0) this season.
• Rams – one different players have recorded 100+ receiving yards in a game this season – equal-most in the NFL, heading into Week 2.
• Heading into Week 2, the Rams rank T1st in the NFL in 4th down percentage (100.0%) this season.

Los Angeles Rams vs. Tennessee Titans Prediction

I’m on the under here. I wasn’t overly enthused with either side offensively in their openers, as the Rams just leaned heavily on their defense to get the job done, and the Titans still look like there’s going to be some definite growing pains to go through with Cam Ward under center. This to me feels like a first to 20 wins kind of game, so give me the under in this one.