Los Angeles Chargers vs New York Giants Prediction 9/28/2025 Today’s NFL Picks

The Los Angeles Chargers and the New York Giants meet in week 4 NFL action from MetLife Stadium on Sunday. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Los Angeles Chargers vs. New York Giants prediction.

Los Angeles Chargers Recap

The Los Angeles Chargers come into this game looking to add on to their 23-20 win over the Denver Broncos last time out to start the year at 3-0. After this game, the Chargers will head home for a game against the Washington Commanders.

Chargers Looking To Stay Undefeated

Justin Herbert has thrown for 860 yards, 8 touchdowns and an interception on 66.7% passing while Omarion Hampton leads Los Angeles in rushing with 142 rushing yards and a TD this season. Quentin Johnston has 239 receiving yards and 3 touchdowns to lead the Chargers’ group while Keenan Allen has 194 receiving yards and 3 touchdowns with 19 grabs and Ladd McConkey’s added 15 catches and 163 receiving yards as well. On defense, Derwin James Jr. has a team-high 26 total tackles including 18 solo tackles while Daiyan Henley has a pair of sacks and an interception while the Chargers’ defensive unit as a whole has combined for 7 sacks and 3 interceptions so far this season. 

New York Giants Recap

The New York Giants come into this game looking to rebound from their 22-9 loss at the hands of the Kansas City Chiefs last time out to sit at 0-3 this season. After this game, the Giants will head on the road for a game against the New Orleans Saints.

Giants Still Searching For First W

Russell Wilson has thrown for 778 yards, 3 touchdowns and 3 interceptions on 59.1% passing while also rushing for 94 rushing yards. Cam Skattebo also has 102 rushing yards with 2 touchdowns while Malik Nabers leads the Giants with 16 catches for 251 yards and 2 touchdowns and Wan’Dale Robinson has 15 grabs for 223 yards and a TD. On defense, Bobby Okereke has a team-high 34 total tackles including 15 solo tackles while Paulson Adebo has 27 total tackles including a team-high 23 solo tackles. Brian Burns also leads the Giants with 4 sacks as well this season. 

Los Angeles Chargers @ New York Giants Betting Trends: Week 4

Why the New York Giants will win

• The Chargers have lost three of their last four September games as favorites against NFC opponents.
• The home team has won five of the Giants’ last six games.
• The Giants have covered the spread in five of their last six Week 4 games.
• The Chargers have failed to cover the spread in four of their last five September games as favorites against NFC opponents.
• The Chargers have lost the first quarter in each of their last two Week 4 games as favorites against NFC opponents.
• The Chargers have lost the first half in three of their last four games against NFC East opponents.
• The Giants have scored the first touchdown in each of their last five home games against AFC West opponents.

Why the Los Angeles Chargers will win

• The Giants have lost 14 of their last 15 games.
• The Chargers have won each of their last six road games against NFC opponents on a losing streak.
• The Chargers have covered the spread in each of their last six games against teams that held a losing record.
• The Giants have failed to cover the spread in each of their last five games against teams that held a winning record.
• The Chargers have won the first quarter in each of their last six games in September.
• The Chargers have won the first half in each of their last nine Sunday games as favorites.
• The Chargers have scored the first touchdown in each of their last four Week 4 games.

Total Points Facts

• Each of the Chargers’ last seven Sunday games played on the East Coast have gone UNDER the total points line.
• Each of the Giants’ last six September games as home underdogs have gone UNDER the total points line.

New York Giants Player Prop Facts

• Malik Nabers has recorded 64+ receiving yards in nine of the Giants’ last 10 games.
• Tyrone Tracy has scored a touchdown in three of the Giants’ last four games as underdogs following a home loss.
• Tyrone Tracy has recorded 23+ rushing yards in each of the Giants’ last 10 games played on the East Coast.
• Tyrone Tracy has recorded 32+ rushing and receiving yards in each of the Giants’ last 16 games.
• Heading into Week 4, Malik Nabers ranks T1st in the NFL in 20+ yard receiving touchdowns (2) this season.

Los Angeles Chargers Player Prop Facts

• Keenan Allen has scored the first touchdown in three of his last four September road appearances.
• Keenan Allen has scored a touchdown in each of the Chargers’ last three games.
• Justin Herbert has recorded 23+ completions in five of the Chargers’ last six regular season games.
• Keenan Allen has recorded 49+ receiving yards in each of his last nine appearances with the Chargers as road favorites.
• Justin Herbert has recorded 281+ passing yards in five of the Chargers’ last six regular season games.
• Najee Harris has recorded 28+ rushing yards in 22 of his last 23 appearances with his team as a favorite.
• Najee Harris has recorded 42+ rushing and receiving yards in each of his last 10 appearances on the East Coast.
• Heading into Week 4, Justin Herbert ranks 1st in the NFL in passing yards (860) this season.

Matchup/League Facts

• Giants – four different players have recorded 60+ receiving yards in a game this season – equal-most in the NFL, heading into Week 4.
• Giants – two different players have recorded 100+ receiving yards in a game this season – equal-most in the NFL, heading into Week 4.
• Chargers – five different players have recorded 50+ receiving yards in a game this season – equal-most in the NFL, heading into Week 4.
• Heading into Week 4, the Chargers rank 1st in the NFL in red zone percentage against (25.0%) this season.

Los Angeles Chargers vs. New York Giants Prediction

I’m on the Chargers here. Not always easy to lay points on the road and the Giants have announced the QB change to Jaxson Dart, so that could give the Giants a bit of a jolt offensively and there’s no real tape on Dart in the NFL. However, the Chargers are still a really tough defense to go up against in your NFL regular season debut, and the Chargers have looked really stout on defense and really consistent on offense. I’ll side with the Chargers in this one.