Aug 16, 2025; Paradise, Nevada, USA; Las Vegas Raiders quarterback Geno Smith (7) warms up before a preseason game against the San Francisco 49ers at Allegiant Stadium. Mandatory Credit: Stephen R. Sylvanie-Imagn Images

Las Vegas Raiders vs Arizona Cardinals Prediction 8/23/2025 Today’s NFL Picks

Pick details

Las Vegas (0-1-1) vs Arizona (1-1)

August 23, 2025 at 10:00 PM EDT

The Line: Betting Odds: Arizona +2.5 — Over/Under: +37.5

(Get latest betting odds)

The Las Vegas Raiders and the Arizona Cardinals meet in week 3 NFL Preseason action from State Farm Stadium on Saturday. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Las Vegas Raiders vs. Arizona Cardinals prediction.

Las Vegas Raiders Recap

The Las Vegas Raiders come into this game looking to rebound after falling to 0-1-1 in the preseason thanks to a 22-19 loss at the hands of the San Francisco 49ers last time out. After this game, the Raiders will kick off their 2025 regular season with a game against the New England Patriots.

Raiders Looking To Salvage Win In Preseason Finale

Aidan O’Connell threw for 138 yards and an interception on 15 of 23 passing while Geno Smith threw for 55 yards on 6 of 8 passing and Cam Miller tossed for 25 yards and an INT on 2 of 6 passing. Ashton Jeanty led the Raiders with 33 rushing yards and a TD on the ground while Chris Collier chipped in 26 rushing yards as well. Carter Runyon led the way for the Raiders with 2 grabs for 29 yards while Brock Bowers and Shedrick Jackson each had 28 receiving yards with Jackson logging 3 receptions as well. On defense, Chris Smith II had a team-high 7 solo tackles while Tommy Eichenberg added 7 total tackles including 4 solo tackles. Andre Carter II had a sack and Jeremy Chinn added an INT as well for the Raiders’ defense.

Arizona Cardinals Recap

The Arizona Cardinals come into this game looking to bounce back from a 27-7 loss at the hands of the Denver Broncos last time out to fall to 1-1 in the preseason. After this game, the Cardinals will kick off their 2025 regular season with a road game against the New Orleans Saints.

Cardinals Looking To Rebound In Final Preseason Matchup

Jacoby Brissett threw for 57 yards and a TD on 6 of 8 passing while Clayton Tune threw for 56 yards on 13 of 20 passing. Emari Demercado added a team-high 15 rushing yards while Simi Fehoko added 21 receiving yards and a touchdown. Michael Carter also had a team-high 5 receptions for Arizona in the losing effort. On defense, Jammie Robinson led the way with 8 total tackles including 5 solo tackles while Kitan Crawford added 7 total tackles with 5 solo tackles.

Las Vegas Raiders vs. Arizona Cardinals Prediction

I’m looking at the under in this game. I just really am not a fan of the depth across the board on both sides, as the Raiders QB depth is a bit unnerving and Arizona’s depth is almost non-existent with that offensive showing they had against the Broncos, or lack thereof. Maybe it was just going against the Broncos that threw off the Cardinals, but I don’t expect much here either from either side. Give me the under in this one.

Chris Ruffolo's Pick: Under 37.5

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