Jacksonville Jaguars vs Indianapolis Colts Prediction 12/28/2025 Today’s NFL Picks

In this article, we will formulate a Jaguars vs Colts Prediction for this NFL Week 17 game on Sunday, December 28th. Let’s take a look at the prediction for this NFL matchup.

Indianapolis Colts Preview

The Indianapolis Colts have an 8-6 record this season and are sitting third in the AFC South. They are 8-5-1 ATS, 7-7 in Over/Under and have a 6-1 home record and a 2-5 away record. The Colts are coming off a 16-18 away loss against the Seattle Seahawks and will face the Texans next.

Offensively, the Colts average 28 points per game, ranking 6th in the NFL, while defensively, they allow 21.6 points per game, which is 13th. Indianapolis averages 357.9 total yards per game (229 passing and 128.9 rushing), while allowing 342.7 total yards per game (95.1 rushing and 247.6 passing).

Daniel Jones leads the Colts with 3101 passing yards with 68% completed passes and 19 touchdowns. Jonathan Taylor leads the team in rushing yards with 1443, while Michael Pittman Jr. has a team-high 72 receptions for 725 receiving yards, and seven touchdowns. Defensively, Zaire Franklin has a team-high 104 total tackles (52 of them solo), while Laiatu Latu leads the team in sacks, with 6.5, while Camryn Bynum and Laiatu Latu each have 3 interceptions.

Jacksonville Jaguars Preview

The Jacksonville Jaguars have a 11-4 record this season and are sitting first in the AFC South. They are 10-4-1 ATS, 9-6 in Over/Under and have a 6-2 home record and a 5-2 away record. The Jaguars are coming off a 34-20 away win against the Denver Broncos and will face the Titans next.

Offensively, the Jaguars average 27.3 points per game, ranking 7th in the NFL, while defensively, they allow 20.8 points per game, which is 10th. Jacksonville averages 336.4 total yards per game (218.3 passing and 118.1 rushing), while allowing 317.6 total yards per game (87.3 rushing and 230.3 passing).

Trevor Lawrence leads the Jaguars with 3489 passing yards with 60% completed passes and 26 touchdowns. Travis Etienne leads the team in rushing yards with 999, while Parker Washington has a team-high 45 receptions for 645 receiving yards, and four touchdowns. Defensively, Foyesade Oluokun has a team-high 122 total tackles (61 of them solo), while Josh Hines-Allen leads the team in sacks, with 7, while Devin Lloyd has a team-high 5 interceptions.

Jacksonville Jaguars @ Indianapolis Colts Betting Trends: Week 17

Why the Indianapolis Colts will win

• The home team has won 19 of the Jaguars’ last 20 Week 17 games.
• The Jaguars have lost each of their last eight road games without Travis Etienne.
• The Jaguars have failed to cover the spread in seven of their last eight games without Brenton Strange.
• The Colts have covered the spread in each of their last five games as underdogs without DeForest Buckner.
• The Colts have won the first quarter in four of their last five games as underdogs against AFC opponents.
• The Jaguars have lost the first half in 15 of their last 17 Week 17 road games.
• The Colts have scored the first touchdown in 12 of their last 13 games.

Why the Jacksonville Jaguars will win

• The favorites have won each of the Jaguars’ last 12 games at Lucas Oil Stadium.
• The Colts have lost each of their last seven games against opponents on a winning streak.
• The Jaguars have covered the spread in each of their last six games without Jordan Akins.
• The Colts have failed to cover the spread in each of their last six Week 17 games.
• The Jaguars have won the first quarter in each of their last six games against AFC opponents.
• The Jaguars have won the first half in each of their last six games as favorites against the Colts.
• The Jaguars have scored the first touchdown in each of their last seven games.

Total Points Facts

• Each of the last six games between the Jaguars and Colts have gone OVER the total points line.
• Each of the Jaguars’ last six Week 17 road games against AFC South opponents have gone UNDER the total points line.
• Three of the last four games between AFC South teams have gone UNDER the total points line.

Indianapolis Colts Player Prop Facts

• Jonathan Taylor has scored at least one touchdown in 10 of his 11 previous December appearances against AFC opponents.
• Philip Rivers has recorded 166+ passing yards in each of his last 30 December appearances against AFC opponents.
• Josh Downs has recorded 27+ receiving yards in each of his 11 previous appearances with the Colts as home underdogs.
• Jonathan Taylor has recorded 121+ rushing and receiving yards in each of the Colts’ last four home games against AFC South opponents.
• Jonathan Taylor has recorded 116+ rushing yards in each of his three previous home appearances against the Jaguars.
• Philip Rivers has recorded 21+ completions in each of his last nine appearances with his team as an underdog against AFC opponents.
• Heading into Week 17, Jonathan Taylor ranks 1st in the NFL in touchdowns (19) this season.

Jacksonville Jaguars Player Prop Facts

• Jakobi Meyers has scored a touchdown in each of his last five appearances with his team as a road favorite.
• Trevor Lawrence has recorded 234+ passing yards in seven of the Jaguars’ last eight games as favorites following a win.
• Jordan Akins has recorded 10+ receiving yards in each of his last six regular season appearances with his team as a favorite.
• Jakobi Meyers has recorded 56+ rushing and receiving yards in each of his last five appearances with his team as a road favorite against AFC opponents.
• Trevor Lawrence has recorded 20+ rushing yards in each of the Jaguars’ last five road games.
• Trevor Lawrence has recorded 20+ completions in each of his six previous December road appearances against AFC opponents.
• Heading into Week 17, Trevor Lawrence has recorded the equal-most passing touchdowns in a single game this season (5 vs Jets, Week 15).

Matchup/League Facts

• Heading into Week 17, the Colts have played in the equal-highest number of games that went to overtime this season (2).
• Heading into Week 17, the Colts have recorded the equal-most home wins by a margin of 20+ points this season (3).
• Jaguars – seven different players have recorded 70+ receiving yards in a game this season – equal-most in the NFL, heading into Week 17.
• Jaguars – five different players have recorded 90+ receiving yards in a game this season – equal-most in the NFL, heading into Week 17.

Jaguars vs Colts Prediction

In this Jaguars vs Colts Prediction, the Jaguars are coming as -6.5-point road favorites. The Jaguars have a better overall record and are very strong on the road, but the Colts have been almost perfect at home this season. Both teams are coming into this matchup on opposite trajectories, as the Colts have four consecutive losses, while on the other hand, the Jags have won six straight and have covered the spread in all six. Both teams have similar numbers both offensively and defensively, but given their recent form, I have to take the Jags here as they are also 4-1 in their last 5 meetings against the Colts. Take the Jaguars and lay the -6.5 points on the road.

Nikos Lagouretos's Pick: Jacksonville Jaguars -6.5