Jacksonville Jaguars vs Denver Broncos Prediction 9/20/2026 Today’s NFL Picks

The Jacksonville Jaguars and the Denver Broncos meet Sunday in NFL action from Empower Field at Mile High in Denver. Here’s a Jaguars vs Broncos prediction. We will look at this from a betting perspective and determine the best Jaguars vs Broncos pick. We will examine the recent form and player performances for both teams, as well as the recent betting trends and streaks pertaining to this matchup. As we conclude, we will tie it all together with a summary that produces a sensible pick for a favorable betting outcome in this game.

Jacksonville Jaguars Betting Preview

The Jaguars had something of an overachieving season in 2025, improving on their 2024 mark of 4-13 and flipping it to go 13-4. It was the team’s first 10-win season since 2017, and they would clinch the AFC South title. Unfortunately for the Jags however, they would lose a tough game versus the Buffalo Bills in the Wild Card Playoffs, falling 27-24.

In their opener last weekend versus the Cleveland Browns, the Jags played a pretty nice game. Jacksonville was up 24-0 by the end of the first half, then added 10 more points from there in an eventual 34-10 victory. QB Trevor Lawrence was 18-of-23 for 245 yards and four touchdowns. Tops in receiving was Parker Washington with five catches for 83 yards and a score.

Denver Broncos Betting Preview

Over on the Denver side, they won a string of close games in 2025, powering their way to a nice 14-3 overall record. The Broncos tied the franchise record for victories (1998) with that run, also bagging their first AFC West division championship and No. 1 seed since 2015. Denver took out the Buffalo Bills in the Divisional Playoffs but lost the AFC Championship to the New England Patriots.

In the Monday matchup versus the Kansas City Chiefs, the Broncos were all tied up after one quarter and went into the locker room down just seven points. Denver was outscored 17-3 the rest of the way however, leading to a 31-10 loss. QB Bo Nix was 17-of-28 for 131 yards, one TD and one pick. JK Dobbins rushed eight times for 36 yards in the defeat as well.

Jacksonville Jaguars @ Denver Broncos Betting Trends: Week 2

Why the Denver Broncos will win

• The Jaguars have lost each of their last eight Week 2 road games against AFC opponents.
• The Broncos have won each of their last seven home games following a Division game.
• The Broncos have covered the spread in each of their last seven home games following a Division game.
• The Jaguars have failed to cover the spread in five of their last six games as underdogs without Brenton Strange.
• The Jaguars have lost the first half in 22 of their last 25 games as underdogs against AFC West opponents.
• The Broncos have won the first quarter in 10 of their last 14 home games against teams that held a winning record.

Why the Jacksonville Jaguars will win

• The Jaguars have won each of their last six Sunday games against opponents on a losing streak.
• The Broncos have lost each of their last two Week 2 games as favorites.
• The Jaguars have covered the spread in nine of their last 10 Sunday games.
• The Broncos have failed to cover the spread in each of their last four home openers.
• The Broncos have lost the first quarter in three of their last four games as home favorites against AFC opponents.

Total Points Facts

• Each of the Broncos’ last six home openers against AFC opponents have gone UNDER the total points line.
• Nine of the Jaguars’ last 10 games as underdogs following a win have gone OVER the total points line.

Denver Broncos Player Prop Facts

• Courtland Sutton has scored a touchdown in six of the Broncos’ last seven games following a road loss.
• Bo Nix has recorded 247+ passing yards in five of the Broncos’ last six Sunday regular season home games.
• J.K. Dobbins has recorded 50+ rushing yards in each of his last nine appearances with his team as a home favorite.
• Pat Bryant has recorded 31+ receiving yards in each of his last seven regular season appearances.
• J.K. Dobbins has recorded 55+ rushing and receiving yards in each of his last nine appearances with his team as a home favorite.
• Bo Nix has recorded 25+ completions in each of the Broncos’ last five games as favorites following a loss.
• Heading into Week 2, Zach Allen has recorded the equal-most sacks in a single game this season (2.0 vs Chiefs, Week 1).

Jacksonville Jaguars Player Prop Facts

• Parker Washington has scored a touchdown in four of the Jaguars’ last five games.
• Trevor Lawrence has recorded 244+ passing yards in each of the Jaguars’ last six regular season games against AFC opponents.
• Trevor Lawrence has recorded 20+ rushing yards in each of the Jaguars’ last six Sunday road games.
• Jakobi Meyers has recorded 42+ receiving yards in each of his last 11 appearances with his team as an underdog against AFC West opponents.
• Jakobi Meyers has recorded 42+ rushing and receiving yards in each of his last 11 appearances with his team as an underdog against AFC West opponents.
• Trevor Lawrence has recorded 23+ completions in each of his four previous regular season road appearances against AFC West opponents.
• Heading into Week 2, Trevor Lawrence ranks 1st amongst qualified players for passer rating (150.6) this season.

Matchup/League Facts

• Heading into Week 2, the Broncos rank 32nd in the NFL in 1st downs (9) this season.
• Heading into Week 2, the Broncos have averaged just 8.5 points over their last two games – equal-fewest in the league over that span.
• Heading into Week 2, the Jaguars rank T1st in the NFL in red zone percentage against (0.0%) this season.
• Heading into Week 2, the Jaguars rank 1st in the NFL in 3rd down percentage against (12.5%) this season.

Jaguars vs Broncos Prediction

I’ll take a stab on the Jaguars here but you could argue it either way. Sure, it was a home game against the Browns, but Jacksonville looked good in their opener last weekend. The Jaguars posted 360 total yards with 6.4 yards per play and 23 first downs without a turnover. The defense gave up just 14 first downs and 1-of-8 on third downs alongside two takeaways on the other side. Most people have Jacksonville pegged for a regression this year, but if they continue to show up in winnable games they’ve got a good shot at a return to the playoffs. This weekend’s matchup will be a better barometer of where the Jags stand at this point in the early-going. 

As for Denver, they didn’t play all that well in a tricky road opener versus the Chiefs. The Broncos gained only 176 total yards (61 rushing) with nine first downs, 2-of-12 on third-down tries and two turnovers. The defense surrendered 220 rush yards and 9-of-17 on third downs on the other side. Denver can certainly turn it around and play better here, but they’ve got lots to improve upon stats-wise. Should be a pretty good matchup overall.

Andrew Jett's Pick: Jacksonville Jaguars +2.5