Indianapolis Colts vs Los Angeles Rams Prediction 9/28/2025 Today’s NFL Picks

The Indianapolis Colts and the Los Angeles Rams meet in week 4 NFL action from SoFi Stadium on Sunday. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Indianapolis Colts vs. Los Angeles Rams prediction.

Indianapolis Colts Recap

The Indianapolis Colts come into this game looking to add on to their 41-20 win over Tennessee last time out to sit at 3-0 this season. After this game, the Colts will head home for a game against the Las Vegas Raiders.

Colts Looking To Stay Unbeaten

Daniel Jones has thrown for 816 yards and 3 touchdowns on 71.6% passing while also rushing for 3 TDs as well this season. Jonathan Taylor has rushed for 338 yards to lead the Colts on the ground while Tyler Warren has 14 catches for 193 yards and Michael Pittman Jr. has 16 grabs for 193 receiving yards and 2 touchdowns. Alec Pierce also has 171 receiving yards as well this season. On defense, Nick Cross has a team-high 20 total tackles while Cam Bynum has a pair of interceptions for the Colts’ defense so far this season. As a unit, Indianapolis’ defense has combined for 7 sacks and 4 interceptions so far this season.

Los Angeles Rams Recap

The Los Angeles Rams come into this game looking to rebound from a 33-26 loss at the hands of the Philadelphia Eagles last time out to slip to 2-1 this season. After this game, the Rams will take on the San Francisco 49ers in an NFC West matchup at home.

Rams Looking To Rebound From First L

Matthew Stafford has thrown for 739 yards, 5 touchdowns and 2 interceptions on 66.3% passing while Kyren Williams has rushed for 226 yards and a touchdown to lead the Rams on the ground. Puka Nacua has a team-high 29 catches for 333 yards while Davante Adams has 13 grabs for 213 yards and 2 touchdowns. On defense, Kam Curl has a team-high 26 total tackles including 19 solo tackles. Byron Young has a team-high 4 sacks while the Rams’ defense as a whole has combined for 12 sacks and an interception so far this season.

Indianapolis Colts @ Los Angeles Rams Betting Trends: Week 4

Why the Los Angeles Rams will win

• The Rams have won each of their last 12 Sunday games as favorites.
• The Colts have lost each of their last nine games as underdogs against NFC opponents.
• The Colts have failed to cover the spread in each of their last six games as underdogs against NFC opponents.
• The Rams have covered the spread in each of their last six Sunday games as favorites.
• The Rams have won the first quarter in 11 of their last 12 games against AFC South opponents.
• The Rams have won the first half in each of their last five Week 4 games against AFC opponents.
• The Rams have scored the first touchdown in seven of their last eight games against AFC South opponents.

Why the Indianapolis Colts will win

• The Colts have won four of their last five September games as underdogs.
• The Rams have lost three of their last four Week 4 games.
• The Colts have covered the spread in eight of their last nine games in September.
• The Rams have failed to cover the spread in each of their last five Week 4 home games.
• The Colts have won the first quarter in five of their last six games as underdogs following a win.
• The Rams have lost the first half in each of their last five games as slight favorites (<-3.5 points).
• The Colts have scored the first touchdown in each of their last seven games as road underdogs.

Total Points Facts

• Each of the Colts’ last eight Sunday games played on the West Coast have gone OVER the total points line.
• Seven of the Rams’ last eight home games following a loss have gone UNDER the total points line.
• Six of the last eight Sunday games at SoFi Stadium have gone OVER the total points line.

Los Angeles Rams Player Prop Facts

• Kyren Williams has scored the first touchdown in each of his last five home appearances.
• Matthew Stafford has recorded 278+ passing yards in each of his five previous appearances against the Colts.
• Puka Nacua has recorded 98+ receiving yards in each of his last seven regular season home appearances.
• Kyren Williams has scored at least one touchdown in each of his last nine Sunday home appearances.
• Kyren Williams has recorded 72+ rushing and receiving yards in 18 of his last 19 appearances.
• Matthew Stafford has recorded 24+ completions in five of his last six home appearances against AFC South opponents.
• Heading into Week 4, Puka Nacua ranks 1st in the NFL in receiving yards (333) this season.

Indianapolis Colts Player Prop Facts

• Daniel Jones has recorded 228+ passing yards in each of his last five September appearances.
• Jonathan Taylor has recorded 96+ rushing yards in seven of the Colts’ last eight games.
• Jonathan Taylor has scored at least one touchdown in five of the Colts’ last six games.
• Anthony Richardson has scored the first touchdown in three of his last four appearances with the Colts as road underdogs.
• Jonathan Taylor has recorded 108+ rushing and receiving yards in each of the Colts’ last four games played on the West Coast.
• Jonathan Taylor has recorded 16+ receiving yards in each of the Colts’ last six September games.
• Daniel Jones has recorded 20+ completions in seven of his last eight appearances with his team as an underdog.
• Heading into Week 4, Jonathan Taylor ranks 1st in the NFL in rushing yards (338) this season.

Matchup/League Facts

• Rams – two different players have recorded 100+ receiving yards in a game this season – equal-most in the NFL, heading into Week 4.
• Rams – eight different players have recorded 1.0 sacks or more in a game this season – equal-most in the NFL, heading into Week 4.
• Colts – one different players have recorded 100+ rushing yards in a game this season – equal-most in the NFL, heading into Week 4.
• Colts – five different players have recorded 50+ receiving yards in a game this season – equal-most in the NFL, heading into Week 4.

Indianapolis Colts vs. Los Angeles Rams Prediction

I’m on the Rams here. Maybe I’m just a Daniel Jones hater, but I just don’t believe in what he’s sold so far. Sure, the Colts are 3-0 but they could’ve and probably should’ve lost that game to Denver had the Broncos not shot themselves in the foot on that game-winning field goal, and the other two wins came against Miami and Tennessee who are a combined 0-6 so far this season. The Rams have a stout defensive unit that I think will be after Daniel Jones here and I think at home, Los Angeles wins this game by a touchdown. Give me the Rams here.