Eagles vs Bills Prediction 12/28/2025 Today’s NFL Picks

In this article we will formulate an Eagles vs Bills prediction for this NFL game on Sunday, December 28th at Highmark Stadium in Orchard Park, New York. Let’s take a look at the prediction for this week 17 matchup.

Philadelphia Eagles Betting Preview

The Philadelphia Eagles are 10-5 this season after they defeated Washington by a score of 29-18 in their last game. Philadelphia trailed 10-7 at halftime, but they scored the first 22 points of the second half to get the comeback win. The Eagles out gained Washington by a total of 385-220, went 4-9 on third downs, and tied the turnover battle at one in the game. Jalen Hurts went 22-30 for 185 yards and two touchdowns, while Saquon Barkley rushed 21 times for 132 yards and one score. AJ Brown led the receivers with nine catches for 95 yards in the win. 

Prior to that game, Philadelphia defeated the Raiders by a score of 31-0, but lost to the Chargers by a score of 22-19 before that. The Eagles have won two games in a row and they clinched the NFC East standings. Philadelphia has scored 23.3 points per game with 197.9 passing yards and 121.7 rushing yards per game, while they have allowed 19.3 points against per game this season. Jalen Hurts has thrown for 3,114 yards, 24 touchdowns, and six interceptions, while AJ Brown has 73 receptions for 935 yards and seven scores this season. 

Buffalo Bills Betting Preview

The Buffalo Bills are 11-4 this year after they defeated Cleveland by a score of 23-20 in their last game. Buffalo trailed 7-0 in the first quarter, but they led 20-10 at halftime. Buffalo extended that lead to 23-10 in the third quarter, but they were outscored 10-0 the rest of the way and barely escaped with the win. The Bills were out gained by a total of 294-259, went 2-8 on third downs, and won the turnover battle by a total of 2-0 in the game. Josh Allen went 12-19 for 130 yards, while James Cook rushed 16 times for 117 yards and two scores. Khalil Shakir led the receivers with four catches for 34 yards in the win. 

Prior to that game, Buffalo defeated the Patriots by a score of 35-31 and the Bengals by a score of 39-34. The Bills have won four games in a row and they are currently second in the AFC East standings. Buffalo has scored 28.9 points per game with 214.2 passing yards and 158.9 rushing yards per game, while they have allowed 22.9 points against per game this season. Josh Allen has thrown for 3,406 yards, 25 touchdowns, and 10 interceptions, while James Cook has rushed for 1,532 yards and 12 scores on 287 carries this year. 

Why the Buffalo Bills will win

• The Bills have won each of their last 18 home games following a road win.
• The Bills have covered the spread in 10 of their last 11 Sunday games against teams that held a winning record.
• The Eagles have failed to cover the spread in four of their last five December games as road underdogs.
• The Eagles have lost the first quarter in each of their last three December road games against AFC opponents.
• The Eagles have lost the first half in three of their last four games.

Total Points Facts

• Eight of the Bills’ last nine games as home favorites following a road win have gone OVER the total points line.
• Each of the Eagles’ last four games without Grant Calcaterra have gone OVER the total points line.

Buffalo Bills Player Prop Facts

• James Cook has scored two or more touchdowns in three of the Bills’ last four games as favorites against teams on a winning streak.
• James Cook has scored at least one touchdown in six of the Bills’ last seven games as favorites against teams that held a winning record.
• James Cook has recorded 111+ rushing and receiving yards in each of the Bills’ last six games as favorites.
• James Cook has recorded 107+ rushing yards in four of the Bills’ last five games as favorites.
• Keon Coleman has recorded 16+ receiving yards in each of his 12 previous regular season appearances at Highmark Stadium.
• Heading into Week 17, James Cook has recorded the equal-most rushing attempts in a single game this season (32 vs Steelers, Week 13).

Philadelphia Eagles Player Prop Facts

• Saquon Barkley has scored at least one touchdown in each of his last five December road appearances.
• Jalen Hurts has recorded 19+ completions in five of the Eagles’ last six road games.
• Dallas Goedert has recorded 35+ receiving yards in each of his last five December appearances against AFC opponents.
• Jalen Hurts has recorded 197+ passing yards in seven of the Eagles’ last eight Sunday regular season games as road underdogs.
• Tank Bigsby has recorded 33+ rushing and receiving yards in each of his last six Sunday appearances with his team as an underdog.
• Tank Bigsby has recorded 28+ rushing yards in each of his last seven appearances with his team as an underdog against AFC opponents.
• Heading into Week 17, Jalen Hurts has thrown the equal-most interceptions in a single game this season (4 vs Chargers, Week 14).

Matchup/League Facts

• Heading into Week 17, the Bills rank 1st in the NFL in rushing yards per game (158.9) this season.
• Heading into Week 17, the Bills rank 32nd in the NFL in average punt return (5.5 yards) this season.
• Eagles – two different players have recorded 100+ rushing yards in a game this season – equal-most in the NFL, heading into Week 17.
• Heading into Week 17, the Eagles rank 1st in the NFL in red zone percentage (71.8%) this season.

Eagles vs Bills Prediction 

Buffalo comes into this matchup looking for their fifth win in a row and they are trying to catch the Patriots in the AFC East standings. The Bills are 6-1 at home this year and they have scored 26+ in three of their last four. Philadelphia has won two games in a row against two awful teams, but they did drop the three games before that. The Eagles are 5-3 on the road and while their offense has been inconsistent, they should be able to run the ball against a bad Buffalo defense. This should be a great game to watch, but I am going to side with Buffalo, as I will take Allen over Hurts all day.

David Racey is 101-79 (56%) in the NFL this season and is one of the top NFL cappers on the NFL Leaderboard. Click here for his premium plays for this week!

David Racey's Pick: Bills ML