Denver Broncos vs Indianapolis Colts Prediction 9/14/2025 Today’s NFL Picks

The Denver Broncos and Indianapolis Colts meet Sunday in NFL action at Lucas Oil Stadium. Here’s a Denver Broncos vs Indianapolis Colts Prediction. This article will include a Denver Broncos vs Indianapolis Colts Pick.

Denver Broncos Betting Preview

The Denver Broncos beat the Titans, and they play the Chargers and Bengals next. The Denver Broncos have won 6 of their last 8 games. Bo Nix is completing 62.5 percent of his passes for 176 yards, 1 touchdown, and 2 interceptions. Courtland Sutton and Troy Franklin have combined for 105 receiving yards and 1 touchdown, while Evan Engram has 3 receptions.

The Denver Broncos ground game is averaging 151 yards per contest, and RJ Harvey leads the way with 70 yards on 6 carries. Defensively, Denver is allowing 12 points and 133 yards per game. Talanoa Hufanga leads the Denver Broncos with 10 tackles, Nick Bonitto has 1 sack and Riley Moss has 2 pass deflections.

Indianapolis Colts Betting Preview

The Indianapolis Colts beat the Dolphins, and play the Titans and Chargers next. The Indianapolis Colts have won 5 of their last 8 games. Daniel Jones is completing 75.9 percent of his passes for 272 yards, 1 touchdown, and 0 interceptions. Michael Pittman Jr. and Tyler Warren have combined for 156 receiving yards and 1 touchdown, while Alec Pierce has 1 reception.

The Indianapolis Colts ground game is averaging 156 yards per contest, and Jonathan Taylor leads the way with 71 yards on 18 carries. Defensively, Indianapolis is allowing 8 points and 211 yards per game. Charvarius Ward leads the Indianapolis Colts with 6 tackles, Kenny Moore II has 1 sack and Cam Bynum has 1 interception.

Denver Broncos @ Indianapolis Colts Betting Trends: Week 2

Why the Indianapolis Colts will win

• The Broncos have lost 12 of their last 13 road games before a Division game.
• The underdogs have won each of the Colts’ last three Week 2 games.
• The Colts have covered the spread in each of their last five September games against AFC opponents.
• The Broncos have failed to cover the spread in each of their last four games as road favorites before a Division game.
• The Broncos have lost the first quarter in three of their last four games as road favorites following a win.
• The home team has won the first half in each of the Broncos’ last four games.

Why the Denver Broncos will win

• The Broncos have won each of their last 10 games as favorites.
• The Colts have lost five of their last six Week 2 games at Lucas Oil Stadium.
• The favorites have covered the spread in eight of the Broncos’ last nine games.
• The Colts have failed to cover the spread in each of their last four games against teams that held a winning record.
• The Colts have lost the first quarter in three of their last four Week 2 home games.
• The Broncos have won the first half in 10 of their last 12 games as favorites.

Total Points Facts

• Eight of the Broncos’ last nine games against AFC South opponents have gone UNDER the total points line.
• Five of the Colts’ last six games have gone OVER the total points line.

Indianapolis Colts Player Prop Facts

• Daniel Jones has recorded 236+ passing yards in four of his five previous September appearances against AFC opponents.
• Jonathan Taylor has scored a touchdown in each of his last four appearances with the Colts as underdogs following a home win.
• Jonathan Taylor has recorded 104+ rushing and receiving yards in five of his six previous appearances against AFC West opponents.
• Josh Downs has recorded 48+ receiving yards in each of his last five appearances with the Colts as home underdogs against AFC opponents.
• Anthony Richardson has recorded 46+ rushing yards in each of his last four Sunday appearances.
• Daniel Jones has recorded 22+ completions in each of his last five appearances following a win.
• Heading into Week 2, Daniel Jones ranks T1st in the NFL in rushing touchdowns (2) this season.

Denver Broncos Player Prop Facts

• Courtland Sutton has scored a touchdown in each of the Broncos’ last four day games against teams on a winning streak.
• Courtland Sutton has recorded 65+ receiving yards in six of the Broncos’ last seven games as road favorites against AFC opponents.
• Bo Nix has recorded 18+ rushing yards in each of the Broncos’ last six games against AFC opponents.
• J.K. Dobbins has recorded 75+ rushing and receiving yards in each of his last four Sunday appearances with his team as a road favorite.
• J.K. Dobbins has scored the last touchdown in three of his last four regular season appearances with his team as a favorite against AFC opponents.
• Bo Nix has recorded 22+ completions in each of the Broncos’ last four regular season road games.
• Heading into Week 2, Bo Nix has thrown the equal-most interceptions in a single game this season (2 vs Titans, Week 1).

Matchup/League Facts

• Colts – two different players have recorded one interception or more in a game this season – equal-most in the NFL, heading into Week 2.
• Heading into Week 2, the Colts rank 1st in the NFL in turnover differential (+3) this season.
• Broncos – six different players have recorded 1.0 sacks or more in a game this season – most in the NFL, heading into Week 2.
• Heading into Week 2, the Broncos rank 1st in the NFL in yards allowed per game (133.0) this season.

Denver Broncos vs Indianapolis Colts Prediction

It feels like the Colts are getting respect from oddsmakers because of their week 1 victory, but that had more to do with the Dolphins being inept than anything else. The Colts are still a middle of the road team that loses some points, being quarterbacked by Daniel Jones. Nix didn’t look good opening week, and it’s raising questions about a sophomore slump, but the Broncos do have the best defense in the land and that elevates this squad. Jones against the best defense in the league, this has a chance to get ugly.

The Broncos are 11-3 ATS in their last 14 games as a favorite. I’d need to get more points to consider the Colts in this spot. This feels like a game where the Broncos are just going to bury the Colts, lean on defense and running game and grind out a win by a touchdown. Give me the Broncos.