Carolina Panthers vs Arizona Cardinals Prediction 9/14/2025 Today’s NFL Picks

In this article, we will formulate a Panthers vs Cardinals Prediction for this NFL Week 2 game on Sunday, September 14th at the State Farm Stadium. Let’s take a look at the prediction for this NFL matchup.

Arizona Cardinals Preview

Arizona is coming off a 20-13 road victory in New Orleans in their season opener last week. They covered the spread and the game went under the 44.5-point total. Arizona got outgained by their opponents by 315-276 yards. They had 21/29 completed passes, 130 passing yards, 146 rushing yards, with the turnover battle tied at 0-0. The Cardinals went 6-13 in third down efficiency and had 9-54 penalties.

Kyler Murray had 21/29 passes, a team-high 163 passing yards and two touchdowns. Trey Benson added a team-high 69 rushing yards, while Trey McBride caught 6 passes for 61 yards. Defensively, Budda Baker had 10 total tackles, five of them solo, while Baron Browning had one sack. Arizona had no interceptions.

Carolina Panthers Preview

Carolina is coming off a 10-26 road defeat in Jacksonville in their season opener last week. They failed to covered the spread and the game went under the 45-point total. Carolina got outgained by their opponents by 378-255 yards. They had 18/35 completed passes, 142 passing yards, 113 rushing yards, with Jacksonville winning the turnover battle 1-3. The Panthers went 8-15 in third down efficiency and had 4-35 penalties.

Bryce Young had 18/35 passes, a team-high 154 passing yards, one touchdown but also threw two interceptions. Chuba Hubbard added a team-high 57 rushing yards, while Tetairoa McMillan caught 5 passes for 68 yards. Defensively, Tre’von Moehrig had 11 total tackles, seven of them solo, while no Panther recorded a sack. Jaycee Horn had one interception.

Carolina Panthers @ Arizona Cardinals Betting Trends: Week 2

Why the Arizona Cardinals will win

• The Panthers have lost each of their last eight road games before a Division game.
• The Cardinals have won seven of their last eight Week 2 home games.
• The Panthers have failed to cover the spread in seven of their last eight games as road underdogs before a Division game.
• The Cardinals have covered the spread in each of their last four home games against teams that held a losing record.
• The Cardinals have scored the first touchdown in each of their last eight Sunday games as home favorites.
• The home team has won the first quarter in five of the Cardinals’ last six Week 2 games.
• The Panthers have lost the first half in each of their last 13 games following a road loss.

Why the Carolina Panthers will win

• The Cardinals have lost each of their last six games as home favorites before a Division game.
• The underdogs have won each of the last five games between the Panthers and Cardinals.
• The Cardinals have failed to cover the spread in each of their last six games as home favorites before a Division game.
• The Panthers have covered the spread in seven of their last eight games against the Cardinals.
• The Panthers have scored the first touchdown in seven of their last eight games against the Cardinals.
• The Cardinals have lost the first quarter in four of their last five games as favorites against NFC South opponents.
• The Panthers have won the first half in each of their last 11 Sunday games against the Cardinals.

Total Points Facts

• Eight of the Cardinals’ last nine games as home favorites have gone OVER the total points line.
• Each of the Panthers’ last five games against the Cardinals following a loss have gone OVER the total points line.
• Each of the last three Sunday games at State Farm Stadium have gone OVER the total points line.

Arizona Cardinals Player Prop Facts

• James Conner has scored at least one touchdown in each of his last six appearances against teams with a losing record.
• Kyler Murray has recorded 266+ passing yards in each of his five previous Week 2 appearances.
• Michael Wilson has recorded 31+ receiving yards in each of the Cardinals’ last five September home games.
• James Conner has recorded 113+ rushing and receiving yards in each of his last six home appearances.
• James Conner has recorded 90+ rushing yards in each of his last five appearances with the Cardinals as home favorites.
• Kyler Murray has recorded 22+ completions in each of the Cardinals’ last six games played on the West Coast.
• Heading into Week 2, James Conner ranks T1st amongst qualified players for catch rate (100.0%) this season.

Carolina Panthers Player Prop Facts

• Chuba Hubbard has scored at least one touchdown in six of his last seven appearances with the Panthers as underdogs.
• Rico Dowdle has recorded 51+ rushing and receiving yards in each of his last 13 regular season appearances against NFC opponents.
• Rico Dowdle has recorded 46+ rushing yards in each of his last six road appearances against NFC opponents.
• Andy Dalton has recorded 262+ passing yards in four of his last five appearances against the Cardinals.
• David Moore has recorded 15+ receiving yards in each of his last four appearances with his team as an underdog against NFC West opponents.
• Andy Dalton has recorded 26+ completions in each of his last four appearances against the Cardinals.
• Heading into Week 2, Bryce Young has thrown the equal-most interceptions in a single game this season (2 vs Jaguars, Week 1).

Matchup/League Facts

• Heading into Week 2, the Cardinals rank T1st in the NFL in Q1 win percentage (100.0) this season.
• Heading into Week 2, the Cardinals rank T1st in the NFL in Q2 win percentage (100.0) this season.
• Heading into Week 2, the Panthers rank T1st in the NFL in Q4 win percentage (100.0) this season.
• Heading into Week 2, the Panthers rank T1st in the NFL in H2 win percentage (100.0) this season.

Panthers vs Cardinals Prediction

Carolina won their only meeting last season at home by 36-30 in overtime, covering the spread, as the game went over the 47-point total. The Panthers are 7-1 in their last 8 head-to-head meetings against the Cardinals and 7-1 against the spread, having won their last two visits in Arizona. Over is 5-2-1 in their last 8 head-to-head meetings.

In this Panthers vs Cardinals Prediction, the Cardinals are coming as -6.5-point home favorites, with the total set at 45 points. Carolina has been dominating Arizona lately, but they were just 2-6 on the road last season, while Arizona was 6-3 at home, and 11-6 to the over. The Panthers did not look good in their season opener, and are forced to play their second game of the season again on the road, while the Cardinals are playing their home opener of the season. I like the hosts to get the job done in this one, so take the Arizona Cardinals and lay the -6.5 points at home.