Buffalo Bills vs. Cleveland Browns Prediction 8/22/2026 Today’s NFL Picks

The Buffalo Bills and the Cleveland Browns meet in week 2 NFL preseason action from Huntington Bank Field on Saturday. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Buffalo Bills vs. Cleveland Browns Prediction.

Buffalo Bills Recap

The Buffalo Bills come into this game looking to add on to their 29-14 preseason opening win over the Bills last time out to sit at 1-0. After this game, the Bills will take on the Steelers in a game at home.

Bills Looking For Another Strong Showing

Josh Alen threw for 111 yards and a touchdown on 6 of 8 passing while Kyle Allen threw for 108 yards on 14 of 16 passing and Shane Buechele threw for 50 yards on 6 of 9 passing. Ian Wheeler rushed for a team-high 41 yards and a touchdown while Frank Gore Jr. added 38 rushing yards and a TD as well. DJ Moore led the Bills with 61 receiving yards on 3 catches while Stephen Gosnell added 3 grabs for 44 yards and Khalil Shakir had 41 receiving yards. Keleki Latu and Ray Davis each had a team-high 4 receptions. On defense, Toriano Prider. has a team-high 6 total tackles while Jordan Hancock has 2 TFLs. Mike Danna had a pair of sacks while Deone Walker and TJ Parker each had a sack as well in the win. Kani Walker also had an interception as well for the Bills in the win. 

Cleveland Browns Recap

The Cleveland Browns come into this game looking to rebound from a 34-10 loss at the hands of Chicago last time out to sit at 0-1 in the preseason. After this game, the Browns will take on the New England Patriots in a matchup at home.

Browns Throw Up Stinker In Preseason Debut

Deshaun Watson threw for 126 yards on 11 of 15 passing while Shedeur Sanders threw for 79 yards and an interception on 6 of 11 passing and Dillon Gabriel went 5 of 8 for 23 yards and a pick. Davon Booth led the Browns on the ground with 53 rushing yards while KC Concepcion’s lone carry went for 14 yards and a TD. Dylan Sampson added a pair of catches for 43 yards while Gage Larvadain had 4 grabs for 37 yards to led the Browns in catches. On defense, Christopher Edmonds led the Browns with 6 total tackles including 6 solo tackles and a TFL while Winston Reid had 6 total tackles and 3 solo tackles. Khordae Sydnor and Julian Okwara each had a sack and Michael Coats Jr. had an interception as well in the losing effort.

Buffalo Bills vs. Cleveland Browns Prediction

I’m on the Bills here. Buffalo looked really good in their opener and the Browns just did Browns things, finding new and creative ways to lose football games, even in the preseason. I think this is going to be all Bills, even with backups and on the road so give me Buffalo in this one.

Chris Ruffolo's Pick: Buffalo +3