Arizona Cardinals vs New York Giants Prediction 10/4/2026 Today’s NFL Picks

The Arizona Cardinals and the New York Giants meet in week 4 NFL action from MetLife Stadium on Sunday. We will look at this from a betting perspective and determine the best bets for this game. Here’s an Arizona Cardinals vs. New York Giants prediction.

Arizona Cardinals Recap

The Arizona Cardinals come into this game looking to rebound from a 36-30 loss at the hands of San Francisco last time out to sit at 1-2 this season. After this game, the Cardinals will head home for a game against the Detroit Lions.

Cardinals Drop Back-To-Back Games

Jacoby Brissett has thrown for 652 yards, 4 touchdowns and 1 interception on 70.1% passing while Jeremiyah Love leads Arizona in rushing with 160 yards and 1 touchdown through 3 games this season. Tyler Allgeier sits behind Love on the ground with 70 yards and 0 TDs. Trey McBride leads the Cardinals in receiving with 211 yards and 26 catches along with 2 TDs, while Michael Wilson trails with 163 yards and 18 catches. On defense, Jack Gibbens has a team-high 24 tackles while Arizona’s defense as a whole has combined for 4 sacks and 1 interception through 3 games this season.

New York Giants Recap

The New York Giants come into this game looking to add on to their 12-7 win over the New York Giants last time out to sit at 2-1 this season. After this game, the Giants will head on the road for a game against the Commanders.

Giants Looking To Stay Above .500

Jaxson Dart has thrown for 250 yards, 3 touchdowns and 0 interceptions on 76.5% passing while Cam Skattebo leads New York in rushing with 177 yards and 1 touchdown through 3 games this season. Najee Harris sits behind Skattebo on the ground with 58 yards and 0 TDs. Isaiah Likely leads the Giants in receiving with 124 yards and 15 catches along with 2 TDs, while Malik Nabers trails with 96 yards and 12 catches. On defense, Arvell Reese has a team-high 25 tackles while New York’s defense as a whole has combined for 1 sack and 3 interceptions through 3 games this season.

Arizona Cardinals @ New York Giants Betting Trends: Week 4

Why the New York Giants will win

• The Cardinals have lost each of their last eight games against NFC opponents.
• The Giants have won five of their last six games as underdogs without Jason Pinnock.
• The Cardinals have failed to cover the spread in each of their last five games without Marvin Harrison Jr..
• The Giants have covered the spread in each of their last four home games without Jason Pinnock.
• The Cardinals have lost the first quarter in four of their last five Week 4 games as favorites.
• The Giants have scored the first touchdown in seven of their last nine games as home underdogs.
• The Cardinals have lost the first half in each of their last eight road games against teams that held a winning record.

Why the Arizona Cardinals will win

• The Giants have lost each of their last 10 games against NFC opponents on a losing streak.
• The road team has won seven of the last eight games between the Cardinals and Giants.
• The Cardinals have covered the spread in each of their last seven road games against NFC East opponents.
• The Giants have failed to cover the spread in 13 of their last 14 home games against NFC West opponents.
• The Cardinals have won the first quarter in each of their last six games against the Giants.
• The Cardinals have scored the first touchdown in each of their last seven games as favorites following a loss.
• The Giants have lost the first half in 17 of their last 18 games against NFC West opponents.

Total Points Facts

• Each of the Cardinals’ last eight games as favorites following a loss have gone OVER the total points line.
• Eight of the Giants’ last nine home games in October have gone UNDER the total points line.

New York Giants Player Prop Facts

• Jameis Winston has recorded 21+ completions in six of his seven previous appearances with his team as an underdog against NFC West opponents.
• Najee Harris has recorded 31+ rushing yards in each of his 10 previous home appearances against NFC opponents.
• Jameis Winston has recorded 220+ passing yards in six of his seven previous appearances with his team as an underdog against NFC West opponents.
• Darnell Mooney has recorded 36+ receiving yards in 16 of his last 17 October appearances against NFC opponents.
• Cameron Skattebo has scored at least one touchdown in four of his last five appearances with the Giants as underdogs.
• Najee Harris has recorded 40+ rushing and receiving yards in each of his last 11 October appearances.
• Heading into Week 4, Jevon Holland ranks T1st in the NFL in interceptions (3) this season.

Arizona Cardinals Player Prop Facts

• Jacoby Brissett has recorded 243+ passing yards in eight of the Cardinals’ last nine road games.
• Kendrick Bourne has recorded 33+ receiving yards in each of his last 11 regular season appearances against NFC East opponents.
• James Conner has scored at least one touchdown in each of his last eight October appearances with his team as a favorite.
• James Conner has recorded 55+ rushing yards in each of his last six appearances against NFC East opponents.
• Kendrick Bourne has recorded 33+ rushing and receiving yards in each of his last 11 regular season appearances against NFC East opponents.
• Heading into Week 4, Jacoby Brissett has recorded the most completions in a single game this season (38 vs 49ers, Week 3).

Matchup/League Facts

• Giants – three different players have recorded 50+ rushing yards in a game this season – equal-most in the NFL, heading into Week 4.
• Heading into Week 4, the Giants rank T1st in the NFL in 4th down percentage against (0.0%) this season.
• Heading into Week 4, the Cardinals rank T1st in the NFL in 4th down percentage (100.0%) this season.
• Heading into Week 4, the Cardinals have allowed an average of 31.0 points over their last five games – most in the league over that span.

Arizona Cardinals vs. New York Giants Prediction

I’m on the Cardinals here. Not an ideal spot to come into a game having to lay points on the road with the Cardinals, but the fact is that they actually have more stability at QB with Brissett and I’m not sure how much longer Jameis Winston can get away with this. I think the Cardinals are seeing rare opportunities to get wins and I think this is one of the more winnable spots they’ll have for the next little bit. Give me the Cardinals.

Chris Ruffolo's Pick: Arizona -2.5