49ers vs Seahawks Prediction 10/11/2026 Today’s NFL Picks

In this article we will formulate a 49ers vs Seahawks prediction for this NFL game on Sunday, October 11th at Lumen Field in Seattle, Washington. Let’s take a look at the prediction for this week 5 matchup.

San Francisco 49ers Betting Preview

The San Francisco 49ers are 4-0 this season after they defeated the Broncos by a score of 24-14 in their last game. San Francisco was tied 3-3 at halftime, but they scored 21 points in the second half to get another win. The 49ers out gained Denver by a total of 358-296, went 6-13 on third downs, and won the turnover battle by a total of 1-0 in the game. Brock Purdy threw for 218 yards and two touchdowns, while Mike Evans caught five passes for 76 yards. Christian McCaffrey rushed 15 times for 52 yards and one score in the win. 

Prior to that game, San Francisco defeated the Cardinals by a score of 36-30 and the Dolphins by a score of 35-13. The 49ers have scored 30.5 points per game with 251.8 passing yards and 137.3 rushing yards per game, while they have allowed 16.0 points against per game this season. Brock Purdy has thrown for 1,007 yards with 11 touchdowns and one interception this season. 

Seattle Seahawks Betting Preview

The Seattle Seahawks are 3-1 this year after they defeated the Chargers by a score of 30-23 last week. Seattle led 20-6 at halftime and 27-6 in the third quarter, but they allowed 17 points in the second half, before sealing the win. The Seahawks were out gained by a total of 301-286, went 3-12 on third downs, and won the turnover battle by a total of 4-1 in the game. Sam Darnold threw for 168 yards, two touchdowns, and one interception, while JSN caught five passes for 76 yards. Emanuel Wilson rushed 21 times for 81 yards and one score in the win.

Prior to that game, Seattle lost to the Commanders by a score of 33-31, but did beat the Cardinals by a score of 31-7 before that. The Seahawks have scored 26.3 points per game with 237.0 passing yards and 110.3 rushing yards per game, while they have allowed 18.3 points against per game this season. Sam Darnold has thrown for 560 yards with six touchdowns and three interceptions this year. 

Why the Seattle Seahawks will win

• The Seahawks have won each of their last eight games against teams that held a winning record.
• The 49ers have lost each of their last four games without Deebo Samuel.
• The favorites have covered the spread in eight of the 49ers’ last nine games at Lumen Field.
• The 49ers have failed to cover the spread in each of their last five games without Deebo Samuel.
• The 49ers have lost the first quarter in seven of their last eight games as underdogs following a win.
• The Seahawks have won the first half in seven of their last eight October games as favorites against NFC West opponents.

Why the San Francisco 49ers will win

• The 49ers have won each of their last six Sunday games played on the West Coast.
• The Seahawks have lost each of their last two October games as home favorites against NFC opponents.
• The Seahawks have failed to cover the spread in each of their last six Week 5 games against NFC opponents.
• The road team has covered the spread in six of the last seven games between the 49ers and Seahawks.
• The Seahawks have lost the first half in nine of their last 12 games at Lumen Field against teams that held a winning record.

Total Points Facts

• Each of the 49ers’ last five games without George Kittle have gone OVER the total points line.
• Each of the last five games between teams from the same division have gone OVER the total points line.
• Each of the Seahawks’ last four home games without Uchenna Nwosu have gone UNDER the total points line.

Seattle Seahawks Player Prop Facts

• Tory Horton has scored a touchdown in each of his last three Sunday home appearances.
• Cooper Kupp has recorded 43+ receiving yards in each of his last 10 October appearances with his team as a favorite against NFC opponents.
• Sam Darnold has recorded 20+ completions in four of his last five regular season appearances against NFC opponents.
• Drew Lock has recorded 210+ passing yards in four of his last five appearances as a starter.
• Cooper Kupp has recorded 59+ rushing and receiving yards in each of his last 10 October appearances with his team as a favorite against NFC opponents.
• Rashid Shaheed has recorded 20+ rushing yards in three of the Seahawks’ last four games as home favorites against NFC West opponents.
• Heading into Week 5, Sam Darnold has recorded the equal-most passing touchdowns in a single game this season (4 vs Commanders, Week 3).

San Francisco 49ers Player Prop Facts

• Deebo Samuel has scored the first touchdown in each of his three previous appearances at Lumen Field.
• George Kittle has scored at least one touchdown in each of his last six appearances in Sunday games played on the West Coast.
• Deebo Samuel has recorded 48+ receiving yards in each of his last seven appearances with the 49ers as underdogs against NFC West opponents.
• Brock Purdy has recorded 262+ passing yards in five of the 49ers’ last six Sunday games.
• Deebo Samuel has recorded 60+ rushing and receiving yards in each of his last six regular season appearances with the 49ers as underdogs against NFC West opponents.
• Brock Purdy has recorded 24+ rushing yards in each of the 49ers’ last six Sunday games.
• Heading into Week 5, Brock Purdy ranks 1st amongst qualified players for passer rating (126.2) this season.

Matchup/League Facts

• Heading into Week 5, the Seahawks rank 1st in the NFL in yards allowed per game (246.8) this season.
• Heading into Week 5, the Seahawks rank 1st in the NFL in passing yards allowed per game (144.8) this season.
• Heading into Week 5, the 49ers rank 1st in the NFL in Q3 points per game (10.3) this season.
• Heading into Week 5, the 49ers rank T1st in the NFL in Q1 win percentage (75.0) this season.

49ers vs Seahawks Prediction 

San Francisco comes into this matchup with a 4-0 record and they have scored 24+ in all four wins, but they are on the road and they are an underdog here. Seattle is 3-1 on the year, but they have not played great in their last two games. The Seahawks lost to the Commanders and were out gained by the Chargers, but capitalized on LA’s turnovers. It is never easy to win on the road, but I have to take the points with San Francisco with how they are playing.

David Racey's Pick: 49ers +3