Buffalo Bills (9-2) vs San Francisco 49ers (5-6)
Game Info: Sunday, December 1, 2024 at 8:20 pm (Highmark Stadium)
Betting Odds: Buffalo Bills -7 / San Francisco 49ers +7 --- Over/Under: 47.5 Click Here for the Latest Odds
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The San Francisco 49ers and the Buffalo Bills meet in week 13 NFL action from Highmark Stadium on Sunday night football. We will look at this from a betting perspective and determine the best bets for this game. Here’s a San Francisco 49ers vs. Buffalo Bills prediction.
San Francisco 49ers Recap
The San Francisco 49ers will be out to rebound from a 38-10 loss to the Green Bay Packers last time out to drop the Niners to 5-6 on the year. After this game, the 49ers will head home for a matchup with the Chicago Bears.
49ers Drop Back-To-Back Games
Brock Purdy has thrown for 2,613 yards, 13 touchdowns, and 8 interceptions on 66% passing while Jordan Mason’s rushed for 711 yards and 3 touchdowns on the year. George Kittle has a team-high 49 receptions for 642 yards and 8 touchdowns while Deebo Samuel has 511 receiving yards and Jauan Jennings has 47 catches for 628 receiving yards as well on the year. On defense, Fred Warner has a team-high 84 total tackles including 50 solo tackles and 2 interceptions while Nick Bosa has 7 sacks and Leonard Floyd has 6.5 sacks. As a unit, San Francisco’s defense has combined for 28 sacks and 11 interceptions so far this season.
Why the San Francisco 49ers will win
- The 49ers have won each of their last four games as road underdogs following a road loss.
- The 49ers have covered the spread in eight of their last nine games as road underdogs when playing with a rest disadvantage.
- The Bills have failed to cover the spread in each of their last four games at Highmark Stadium following a home win.
Buffalo Bills Recap
The Buffalo Bills come into this game looking to maintain their momentum after their bye week, picking up a 30-21 win over Kansas City last time out to improve to 9-2 on the year. After this game, the Bills will head on the road for a matchup with the Los Angeles Rams.
Bills Win 6th Straight
Josh Allen has thrown for 2,543 yards, 18 touchdowns, and 5 interceptions on 64% passing while also rushing for 316 yards and 5 touchdowns. James Cook has a team-high 596 rushing yards with 10 TDs while Ray Davis has 279 rushing yards and 2 TDs. Khalil Shakir has a team-high 56 receptions for 599 yards and 2 touchdowns while Keon Coleman has 417 receiving yards and 3 TDs. Dalton Kincaid also has 356 receiving yards as well. On defense, Dorian Williams has a team-high 97 total tackles including 59 solo tackles while Greg Rousseau has a team-high 5.5 sacks and AJ Epenesa has 5 sacks as well on the year. As a unit, Buffalo’s defense has put up 27 sacks and 13 interceptions this season.
Why the Buffalo Bills will win
- The Bills have won each of their last 12 home games against opponents on a losing streak.
- The 49ers have lost five of their last six road games against AFC East opponents on a winning streak.
- The 49ers have failed to cover the spread in each of their last six Sunday games against teams that held a winning record.
- The favorites have covered the spread in eight of the Bills' last nine games.
49ers vs. Bills Prediction
I’m on the Bills here. This line seems a bit large, but this is going to be a game where you’ll have to monitor the injury report all week. As it stands, if the 49ers are anything less than 100%, I think you have to roll with Buffalo given how good they’ve been against everyone regardless of how good or bad the opposition is. San Fran would have to get everyone back for me to consider them here as they need a win to really stay alive in the playoff hunt, but I’m not sure even that would be enough. Give me the Bills.
Chris’s Pick Buffalo -7
AUTHOR: Chris Ruffolo
