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San Antonio Spurs vs Los Angeles Lakers Prediction 11/5/2025 Today’s NBA Picks
Pick details
San Antonio (5-1) vs Los Angeles (6-2)
November 5, 2025 at 10:00 PM EST
The Line: Betting Odds: Los Angeles -2.5 — Over/Under: +228.5
The San Antonio Spurs and LA Lakers meet Wednesday in NBA action at the crypto.com Arena. Here’s a San Antonio Spurs vs Los Angeles Lakers Prediction. This article will include a San Antonio Spurs vs Los Angeles Lakers Pick.
The San Antonio Spurs beat the Heat, lost to the Suns, and they play the Rockets next. The Spurs have won 5 of their last 6 games.
The San Antonio Spurs are averaging 118.3 points on 49.8 percent shooting and allowing 108.3 points on 44.5 percent shooting. Victor Wembanyama is averaging 26.7 points and 13.7 rebounds, while Stephon Castle is averaging 20 points and 5.3 assists. Devin Vassell is the third double-digit scorer and Dylan Harper is dishing 3.8 assists. The San Antonio Spurs are shooting 35.2 percent from beyond the arc and 73.8 percent from the free throw line. The San Antonio Spurs are allowing 39.3 percent shooting from deep and are grabbing 47.8 rebounds per game.
The LA Lakers beat the Heat and Trail Blazers, and they play the Hawks next. The Lakers have won 12 of their last 17 regular season games.
The LA Lakers are averaging 119.8 points on 52.9 percent shooting and allowing 116.8 points on 47.3 percent shooting. Luka Doncic is averaging 41.3 points and 11.5 rebounds, while Austin Reaves is averaging 31.1 points and 5.1 rebounds. Rui Hachimura is the third double-digit scorer, and Deandre Ayton is grabbing 8.1 rebounds. The LA Lakers are shooting 33.1 percent from beyond the arc and 79.2 percent from the free-throw line. The LA Lakers are allowing 34.9 percent shooting from deep and are grabbing 40.1 rebounds per game.
The Lakers will be without Adou Thiero, Gabe Vincent, Maxi Kleber, and LeBron James. Austin Reaves is questionable with a groin issue.
The Spurs will be without Kelly Olynyk, Dylan Harper, De’Aaron Fox, and Luke Kornet. Jeremy Sochan and Lindy Waters III are questionable.
The Spurs in the underdog role is appealing when you consider this start, but at some point all of their injuries catch up to them, and now we’re seeing Dylan Harper on the report as well. The Lakers are playing great ball despite their issues, and that includes a 6-2 SU and ATS record. Obviously, I’d like to see the status of Reaves before locking in something, but this chalk is soft. I have to lean Lakers with the way they keep finding ways to win regular season games dating back to last season.
San Antonio Spurs Betting Preview
The San Antonio Spurs beat the Heat, lost to the Suns, and they play the Rockets next. The Spurs have won 5 of their last 6 games.
The San Antonio Spurs are averaging 118.3 points on 49.8 percent shooting and allowing 108.3 points on 44.5 percent shooting. Victor Wembanyama is averaging 26.7 points and 13.7 rebounds, while Stephon Castle is averaging 20 points and 5.3 assists. Devin Vassell is the third double-digit scorer and Dylan Harper is dishing 3.8 assists. The San Antonio Spurs are shooting 35.2 percent from beyond the arc and 73.8 percent from the free throw line. The San Antonio Spurs are allowing 39.3 percent shooting from deep and are grabbing 47.8 rebounds per game.
LA Lakers Betting Preview
The LA Lakers beat the Heat and Trail Blazers, and they play the Hawks next. The Lakers have won 12 of their last 17 regular season games.
The LA Lakers are averaging 119.8 points on 52.9 percent shooting and allowing 116.8 points on 47.3 percent shooting. Luka Doncic is averaging 41.3 points and 11.5 rebounds, while Austin Reaves is averaging 31.1 points and 5.1 rebounds. Rui Hachimura is the third double-digit scorer, and Deandre Ayton is grabbing 8.1 rebounds. The LA Lakers are shooting 33.1 percent from beyond the arc and 79.2 percent from the free-throw line. The LA Lakers are allowing 34.9 percent shooting from deep and are grabbing 40.1 rebounds per game.
Why the Los Angeles Lakers will win
- The Lakers have won each of their last nine night games against Southwest Division opponents.
- The Spurs have lost seven of their last eight night games at Crypto.com Arena.
- The Lakers have covered the spread in each of their last eight games against Southwest Division opponents.
- The Spurs have failed to cover the spread in six of their last eight games at Crypto.com Arena.
Why the San Antonio Spurs will win
- The Spurs have won each of their last four Wednesday games as underdogs.
- The Lakers have lost nine of their last 11 games at Crypto.com Arena against Spurs teams that held a winning record.
- The Spurs have covered the spread in each of their last 12 games as road underdogs against Pacific Division opponents following a loss.
Total Points Facts
- Each of the Lakers’ last four home games have gone OVER the total points line.
- Each of the Spurs’ last six Wednesday games as road underdogs have gone UNDER the total points line.
Los Angeles Lakers Player Facts
- Deandre Ayton has recorded the most field goal attempts without a three-point attempt (86) of any player in the league this season.
- Marcus Smart ranks T14th amongst qualified players for steals per game (1.7) this season.
San Antonio Spurs Player Facts
- Devin Vassell has recorded the most field goal attempts without being blocked (80) of any player in the league this season.
- Keldon Johnson ranks 1st amongst qualified Guards for FG% (61.2%) this season.
Matchup/League Facts
- The Lakers rank 1st in the league for true shooting percentage this season (63.2%).
- The Lakers have used six different starting fives this season – most in the league.
- The Spurs rank 1st in the league for opponent blocks per game this season (2.7).
- The Spurs rank 1st in the league for H2 opponent points per game this season (50.8).
San Antonio Spurs vs Los Angeles Lakers Injury Report
The Lakers will be without Adou Thiero, Gabe Vincent, Maxi Kleber, and LeBron James. Austin Reaves is questionable with a groin issue.
The Spurs will be without Kelly Olynyk, Dylan Harper, De’Aaron Fox, and Luke Kornet. Jeremy Sochan and Lindy Waters III are questionable.
San Antonio Spurs vs Los Angeles Lakers Prediction
The Spurs in the underdog role is appealing when you consider this start, but at some point all of their injuries catch up to them, and now we’re seeing Dylan Harper on the report as well. The Lakers are playing great ball despite their issues, and that includes a 6-2 SU and ATS record. Obviously, I’d like to see the status of Reaves before locking in something, but this chalk is soft. I have to lean Lakers with the way they keep finding ways to win regular season games dating back to last season.
