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Minnesota Timberwolves vs Portland Trail Blazers Prediction 10/22/2025 Today’s NBA Picks
Pick details
Minnesota (0-0) vs Portland (0-0)
October 22, 2025 at 10:00 PM EDT
The Line: Betting Odds: Portland +2.5 — Over/Under: +219.5
The Minnesota Timberwolves and Portland Trail Blazers meet Wednesday in NBA action at the Moda Center. Here’s a Minnesota Timberwolves vs Portland Trail Blazers Prediction. This article will include a Minnesota Timberwolves vs Portland Trail Blazers Pick.
The Minnesota Timberwolves won 49 games last year and have made the conference finals in back-to-back seasons. The Timberwolves are hoping this is the year they get over the hump.
The Timberwolves are pretty much the same team from a year ago with Anthony Edwards, Rudy Gobert, Julius Randle, Mike Coney and Jaden McDaniels in the starting five. Donte DiVincenzo and Naz Reid are the main guys off the bench. This group has shown it can get close to winning the title, the question is it enough to seal the deal, or is another move needed. We’ll find out soon enough.
The Portland Trail Blazers won 36 games last year and are looking for their first playoff trip since the 2020-21 season.
The Trail Blazers are a young team that made strides last season, so there’s some intrigue here. A young core of Shaedon Sharpe, Deni Avdija, Toumani Camara, and Donovan Clingan has potential and is worth keeping together. Jrue Holiday becomes the leader of the locker room and brings defensive pressure to the starting lineup. While Damian Lillard likely misses the entire season, just seeing him back in Portland should uplift the spirits of the entire franchise. The Trail Blazers finished last season strong and played hard until the end. If things carry over, this could be a sneaky dark horse playoff contender. Don’t sleep on these baby Trail Blazers.
Anthony Edwards is questionable for Minnesota due to a back injury.
The Trail Blazers will be without Damian Lillard, Scoot Henderson, and Robert Williams III.
This line feels soft because of the questionable status of Edwards, but I’m going to assume he finds a way to suit up. Either way, the Timberwolves are the better team and should be able to find a way to win. The Trail Blazers are a young squad that’s still trying to prove they can be trusted against the better teams in the league. If Edwards is cleared, this line will move greatly, so you can argue grabbing the soft line now has value if willing to take the chance. I’m rolling with the Timberwolves and banking that Ant-Man plays.
Minnesota Timberwolves Betting Preview
The Minnesota Timberwolves won 49 games last year and have made the conference finals in back-to-back seasons. The Timberwolves are hoping this is the year they get over the hump.
The Timberwolves are pretty much the same team from a year ago with Anthony Edwards, Rudy Gobert, Julius Randle, Mike Coney and Jaden McDaniels in the starting five. Donte DiVincenzo and Naz Reid are the main guys off the bench. This group has shown it can get close to winning the title, the question is it enough to seal the deal, or is another move needed. We’ll find out soon enough.
Portland Trail Blazers Betting Preview
The Portland Trail Blazers won 36 games last year and are looking for their first playoff trip since the 2020-21 season.
The Trail Blazers are a young team that made strides last season, so there’s some intrigue here. A young core of Shaedon Sharpe, Deni Avdija, Toumani Camara, and Donovan Clingan has potential and is worth keeping together. Jrue Holiday becomes the leader of the locker room and brings defensive pressure to the starting lineup. While Damian Lillard likely misses the entire season, just seeing him back in Portland should uplift the spirits of the entire franchise. The Trail Blazers finished last season strong and played hard until the end. If things carry over, this could be a sneaky dark horse playoff contender. Don’t sleep on these baby Trail Blazers.
Why the Portland Trail Blazers will win
- The home team has won each of the last five games between the Timberwolves and Trail Blazers.
- The Timberwolves have lost 31 of their last 37 games at Moda Center.
- The home team has covered the spread in eight of the Timberwolves’ last nine games.
- The Timberwolves have failed to cover the spread in 13 of their last 16 games at Moda Center.
Why the Minnesota Timberwolves will win
- The Trail Blazers have lost five of their last six season openers.
- The Timberwolves have won 10 of their last 11 games as favorites against Western Conference opponents.
- The Trail Blazers have failed to cover the spread in six of their last seven games against Northwest Division opponents.
- The Timberwolves have covered the spread in nine of their last 12 games as road favorites against Western Conference opponents.
Total Points Facts
- Each of the Timberwolves’ last five season openers have gone UNDER the total points line.
- Five of the Trail Blazers’ last six home games against the Timberwolves have gone OVER the total points line.
Minnesota Timberwolves vs Portland Trail Blazers Injury Report
Anthony Edwards is questionable for Minnesota due to a back injury.
The Trail Blazers will be without Damian Lillard, Scoot Henderson, and Robert Williams III.
Minnesota Timberwolves vs Portland Trail Blazers Prediction
This line feels soft because of the questionable status of Edwards, but I’m going to assume he finds a way to suit up. Either way, the Timberwolves are the better team and should be able to find a way to win. The Trail Blazers are a young squad that’s still trying to prove they can be trusted against the better teams in the league. If Edwards is cleared, this line will move greatly, so you can argue grabbing the soft line now has value if willing to take the chance. I’m rolling with the Timberwolves and banking that Ant-Man plays.
