Indiana Pacers vs Cleveland Cavaliers Prediction 11/21/2025 Today’s NBA Picks

The Indiana Pacers and the Cleveland Cavaliers collide at the Rocket Arena on Friday night. Here’s a Indiana Pacers vs Cleveland Cavaliers Prediction. This article will include a Indiana Pacers vs Cleveland Cavaliers Pick.

Indiana Pacers Betting Preview 

The Indiana Pacers have endured a dreadful start to the season as they’ve lost 13 of their first 15 games, but they will be feeling much better after snapping an eight-game losing streak with a 127-118 win over the Hornets on Wednesday. Bennedict Mathurin led the team in scoring with 24 points and 12 rebounds on seven of 13 shooting, Pascal Siakam added 22 points with seven assists, Jay Huff provided 20 points off the bench while Andrew Nembhard chipped in with 16 points and seven assists.

As a team, the Pacers shot 54 percent from the field and 16 of 38 from the 3-point line as they stormed out of the gates with 70 points in the first half. They led by as many as 24 points before they took their foot off the gas in the fourth quarter.

Cleveland Cavaliers Betting Preview 

Meanwhile, the Cleveland Cavaliers have been in pretty good form as they’ve won seven of their last 10 games overall. They will be hoping to bounce back in this one after having their two-game win streak snapped by the red-hot Rockets in a 114-104 loss on Wednesday. De’Andre Hunter led the team with 25 points on six of 11 shooting, Donovan Mitchell added 21 points on eight of 17 shooting while Evan Mobley chipped in with 18 points on seven of 13 shooting.

As a team, the Cavaliers shot 44 percent from the field and 12 of 39 from the 3-point line as they battled in the third quarter to cut an early 22-point deficit to just one point midway through the fourth quarter. Before the Rockets went on their own run. 

Why the Cleveland Cavaliers will win

• The Cavaliers have won each of their last 17 games at Rocket Arena against Central Division opponents that held a losing record.
• The Pacers have lost each of their last 10 games as road underdogs.
• The Pacers have failed to cover the spread in seven of their last eight games.
• The Cavaliers have covered the spread in eight of their last 10 home games following a home loss.

Why the Indiana Pacers will win

• The Pacers have won four of their last five games as underdogs against the Cavaliers.
• The Cavaliers have lost each of their last two games as home favorites against Central Division opponents following a loss.
• The road team has covered the spread in eight of the last nine games between the Pacers and Cavaliers.
• The Cavaliers have failed to cover the spread in 11 of their last 13 home games.

Total Points Facts

• Seven of the Pacers’ last eight games as road underdogs have gone UNDER the total points line.
• Four of the Cavaliers’ last five games against Central Division opponents have gone UNDER the total points line.

Cleveland Cavaliers Player Facts

• De’Andre Hunter ranks 17th in the Eastern Conference amongst qualified players for FT% (86.0%) this season.

Indiana Pacers Player Facts

• Bennedict Mathurin leads all Pacers players for points per 36 minutes (30.2) this season.
• T.J. McConnell leads all Pacers players for assists per 36 minutes (8.4) this season.

Matchup/League Facts

• Eleven different Cavaliers players have scored 15+ points in a game this season – equal-most in the league.
• The Cavaliers rank 2nd in the league for Q3 win percentage this season (75.0%).
• The Pacers rank 30th in the league for three-point percentage this season (30.7%).
• The Pacers rank 30th in the league for opponent free throws made per game this season (24.3).

Indiana Pacers vs Cleveland Cavaliers Prediction

The Pacers are still missing a bunch of players including Tyrese Haliburton, Obi Toppin, Aaron Nesmith and Johnny Furphy, while the Cavaliers are keeping eyes on Darius Garland, Jaylon Tyson and Jarrett Allen who are all questionable for this one. The Pacers were able to get a much-needed win in their last outing to stop a string of eight defeats, but it’s hard to get too excited about beating the Hornets these days.

In contrast, the Cavaliers were playing some great basketball before they ran into a surging Rockets squad in their last outing so it’s no surprise to see them as heavy favorites in this matchup. The Pacers will be feeling better after their latest win, but I don’t think that feeling lasts at all as I have the Cavaliers winning this one comfortably at home despite the injury cloud hanging over them.

Peter Tran's Pick: Cleveland -13.5