Indiana Pacers vs Boston Celtics Prediction 12/22/2025 Today’s NBA Picks

The Indiana Pacers invade the TD Garden to take on the Boston Celtics on Monday night. Here’s a Indiana Pacers vs Boston Celtics Prediction. This article will include a Indiana Pacers vs Boston Celtics Pick.

Indiana Pacers Betting Preview 

The Indiana Pacers have gone cold again as they’ve lost six of their last eight games overall and they will be eager to arrest a four-game slide after getting trounced by the Pelicans in a 128-109 road defeat on Saturday. Pascal Siakam led the team with 22 points on six of 14 shooting, Johnny Furphy added 18 points on seven of 10 shooting off the bench while TJ McConnell chipped in with 16 points and eight assists on eight of 10 shooting.

As a team, the Pacers shot 43 percent from the field and eight of 42 from the 3-point line, but they got off to a terrible start and were always fighting an uphill battle after getting outscored by 44-27 in the first quarter. Andrew Nembhard had a rough game as he shot just two of 11 from the field to finish with seven points while Bennedict Mathurin shot just two of nine for his four points. 

Boston Celtics Betting Preview 

Meanwhile, the Boston Celtics have been in great shape as they’ve won seven of their last nine games overall and they will be aiming for a third straight victory after running past the Raptors in a 112-96 road win on Saturday. Payton Pritchard led the team with 33 points, seven rebounds and 10 assists on 13 of 24 shooting, Derrick White and Anfernee Simons each scored 15 points while Neemias Queta chipped in with 14 points on seven of seven shooting.

As a team, the Celtics shot 46 percent from the field and 12 of 39 from the 3-point line as they got off to a sloppy start. They scored just 17 points in the second quarter to squander an early 13-point lead, but they regrouped and dominated the second half by 63-45 to blow past the Raptors. Despite a cold shooting night from White, who shot just five of 20 from the field. 

Why the Boston Celtics will win

• The Pacers have lost each of their last 12 night games against teams that held a winning record.
• The Celtics have won 10 of their last 11 games against the Pacers at TD Garden following a win.
• The Pacers have failed to cover the spread in seven of their last eight road games on the first leg of a back-to-back.
• The Celtics have covered the spread in each of their last four games against opponents who are on the first leg of a back-to-back.

Why the Indiana Pacers will win

• The Celtics have lost each of their last four games as favorites against Central Division opponents following a win.
• The Pacers have won four of their last six games as road underdogs against Eastern Conference opponents following a loss.
• The Celtics have failed to cover the spread in nine of their last 10 games as favorites against Central Division opponents following a win.
• The Pacers have covered the spread in each of their last six Monday games against the Celtics.

Total Points Facts

• Each of the Pacers’ last six games at TD Garden have gone OVER the total points line.
• Eight of the last nine games between the Pacers and Celtics have gone OVER the total points line.

Indiana Pacers vs Boston Celtics Prediction

The Pacers are still missing Ben Sheppard, Aaron Nesmith and Tyrese Haliburton, while the Celtics have ruled out Jayson Tatum and Jaylen Brown. The Pacers have continued to struggle with their banged up roster, and they didn’t give themselves much of a chance in their last game after allowing the Pelicans to get off to a flyer.

In contrast, the Celtics have continued to win games despite missing their two leading scorers, and it’s no surprise to see them open as double-digit favorites at home in this matchup. The Celtics are certainly vulnerable at the moment, but Pritchard and White have picked up the slack so far, and I think they can maintain their momentum with a comfortable win and cover in this one.

Peter Tran's Pick: Boston -10.5