Indiana Pacers vs Boston Celtics Prediction 1/21/2026 Today’s NBA Picks

The Boston Celtics play host to the Indiana Pacers at the TD Garden on Wednesday night. Here’s a Indiana Pacers vs Boston Celtics Prediction. This article will include a Indiana Pacers vs Boston Celtics Pick.

Indiana Pacers Betting Preview 

The Indiana Pacers have cooled off again as they’ve dropped three of their past four games and they will be hoping to snap a two-game skid after getting beaten by the 76ers in a 113-104 road defeat on Monday. Andrew Nembhard led the team with 25 points and five assists on nine of 15 shooting, Pascal Siakam added 24 points with six rebounds and seven assists while Jay Huff chipped in with 10 points and three blocks.

As a team, the Pacers shot 48 percent from the field and 13 of 34 from the 3-point line as they held the 76ers to just 17 points in the second quarter to take a narrow lead into halftime. But they got smashed by 63-49 in the second half as they just couldn’t take care of the ball, finishing with 24 turnovers for the game to gift the 76ers an easy win in the end. Aaron Nesmith had a night to forget as he shot just one of nine from the field to finish with just seven points with six turnovers. 

Boston Celtics Betting Preview 

Meanwhile, the Boston Celtics haven’t been at their best as they’ve lost four of their last seven games overall. However, they were on a two-game win streak before they fell painfully short to the Pistons in a 104-103 loss on Monday. Jaylen Brown led the team with 32 points and 11 rebounds, Payton Pritchard added 17 points while Sam Hauser chipped in with 16 points on six of nine shooting.

As a team, the Celtics shot 40 percent from the field and 13 of 41 from the 3-point line as they got off to a slow start and had to claw back from an early 12-point deficit to tie the scores with just 2:44 left in the fourth quarter, but they allowed the Pistons to reclaim the lead and fell just short when Brown missed the game winner at the buzzer. 

Why the Boston Celtics will win

• The Pacers have lost each of their last 10 road games against Eastern Conference opponents that held a winning record.
• The Celtics have won 14 of their last 16 games against the Pacers at TD Garden.
• The Celtics have covered the spread in six of their last seven games against the Pacers following a road loss.
• The Pacers have failed to cover the spread in five of their last six road games against Eastern Conference opponents that held a winning record.

Why the Indiana Pacers will win

• The Celtics have lost each of their last two games as home favorites against Central Division opponents following a loss.
• The Pacers have covered the spread in each of their last four night games against the Celtics following a road loss.
• The Celtics have failed to cover the spread in four of their last five games at TD Garden.

Total Points Facts

• Each of the Pacers’ last six games as underdogs have gone UNDER the total points line.
• Nine of the Celtics’ last 10 night games against Central Division opponents have gone UNDER the total points line.

Boston Celtics Player Facts

• Derrick White is one of only two qualified players in the league averaging at least 1.5 threes and 1.5 blocks this season.
• Anfernee Simons is one of only four players to have scored 35+ points off the bench in a game this season.

Indiana Pacers Player Facts

• Pascal Siakam is one of only two qualified players in the league to be leading their team in rebounds per game (6.9) and three-point shooting percentage (38.0%) this season.
• Andrew Nembhard ranks 3rd amongst qualified Forwards for assists per game (7.1) this season.

Matchup/League Facts

• The Celtics rank 30th in the league for free throw attempts per game this season (19.2).
• The Celtics have made the playoffs in 11 consecutive seasons – longest active streak in the NBA.
• The Pacers rank 30th in the league for H1 points per game this season (55.1).
• The Pacers rank 30th in the league for true shooting percentage this season (55.1%).

Indiana Pacers vs Boston Celtics Prediction

The Pacers are still missing Tyrese Haliburton, Obi Toppin and Bennedict Mathurin, while the Celtics have ruled out Jayson Tatum and Josh Minott once again. These teams have already met three times this season with the Pacers leading the series by 2-1 but the last meeting could’ve gone either way with the Pacers eventually winning by 98-96 back on Jan 12. It’s hard to picture anything but a win for the Celtics at home in this spot, but the Pacers have had success against the Celtics this season. I think they can at least keep this one to single digits in the end.

Peter Tran's Pick: Indiana +10.5