Cleveland Cavaliers vs Philadelphia 76ers Prediction 1/16/2026 Today’s NBA Picks

The Philadelphia 76ers play host to the Cleveland Cavaliers once again at the Xfinity Mobile Arena on Friday night. Here’s a Cleveland Cavaliers vs Philadelphia 76ers Prediction. This article will include a Cleveland Cavaliers vs Philadelphia 76ers Pick.

Cleveland Cavaliers Betting Preview 

The Cleveland Cavaliers have been in pretty good form lately as they’ve won six of their last nine games overall and they will be eager to stay hot after blowing past the 76ers in a 133-107 road win on Wednesday. Donovan Mitchell led the team with 35 points, seven rebounds and nine assists, Darius Garland added 20 points with seven assists on eight of 13 shooting while Evan Mobley tallied 17 points with 13 rebounds and six assists.

As a team, the Cavaliers shot 53 percent from the field and 20 of 46 from the 3-point line as they stormed out of the gates and dominated the first quarter by 33-18 to take a 13-point lead into halftime. Before they really broke loose with 73 points in the second half to make it a complete blowout on the road. 

Philadelphia 76ers Betting Preview 

Meanwhile, the Philadelphia 76ers have been in great shape as they’ve won six of their last nine games overall, but they will be hoping to bounce back here after getting beaten by the Cavaliers in a 133-107 loss on Wednesday. Joel Embiid led the team with 20 points on seven of 14 shooting, Paul George added 17 points on seven of 14 shooting while Tyrese Maxey chipped in with 14 points.

As a team, the 76ers shot 40 percent from the field and 12 of 43 from the 3-point line as they got off to a nightmare start and scored just 18 points in the first quarter to fall behind by double digits right off the bat. But that was only the beginning of their nightmare as they leaked 73 points in the second half to get blown out in their own building. 

Why the Philadelphia 76ers will win

• The Cavaliers have lost each of their last four games against Eastern Conference opponents following a win.
• The 76ers have won six of their last seven home games following a loss.
• The 76ers have covered the spread in each of their last nine games against the Cavaliers at Xfinity Mobile Arena following a loss.
• The Cavaliers have failed to cover the spread in each of their last eight night games following a road win.

Why the Cleveland Cavaliers will win

• The 76ers have lost each of their last eight games at Xfinity Mobile Arena against teams that held a winning record.
• The underdogs have won four of the last five games between the Cavaliers and 76ers at Xfinity Mobile Arena.
• The 76ers have failed to cover the spread in each of their last seven games at Xfinity Mobile Arena against teams that held a winning record.
• The underdogs have covered the spread in eight of the last nine games between the Cavaliers and 76ers.

Total Points Facts

• Each of the 76ers’ last nine Friday night games have gone UNDER the total points line.
• Six of the Cavaliers’ last seven games at Xfinity Mobile Arena have gone OVER the total points line.

Philadelphia 76ers Player Facts

• VJ Edgecombe ranks 7th amongst qualified players for steals per game (1.6) this season.
• Quentin Grimes ranks 10th in the Eastern Conference amongst qualified players for FT% (87.0%) this season.

Cleveland Cavaliers Player Facts

• Jaylon Tyson ranks 5th amongst qualified players for 3P% (45.8%) this season.
• Jarrett Allen ranks 4th in the Eastern Conference amongst qualified players for FG% (59.6%) this season.

Matchup/League Facts

• The 76ers rank 1st in the league for Q4 opponent points per game this season (25.7).
• The 76ers rank 1st in the league for Q2 win percentage this season (74.4%).
• The Cavaliers rank 1st in the league for H2 points per game this season (61.8).
• The Cavaliers rank 2nd in the league for field goal attempts per game this season (92.3).

Cleveland Cavaliers vs Philadelphia 76ers Prediction

The Cavaliers are still missing Max Strus, Darius Garland, Sam Merrill and Dean Wade, while the 76ers are keeping an eye on Dominick Barlow who is questionable for this one. Both teams are coming into this contest in similar form, but it was the Cavaliers who won rather easily on Wednesday thanks to a big game from Mitchell.

The Cavaliers are still dealing with a bunch of injuries, but it’s the loss of Garland that hurts them the most in this matchup as Garland was instrumental in Wednesday’s win. It’s always tough to beat the same team twice in a row in their own building, so I will back the 76ers to get their revenge in this spot.

Peter Tran's Pick: Philadelphia -1.5