Nov 10, 2025; Detroit, Michigan, USA;  Detroit Pistons center Jalen Duren (0) dribbles defended by Washington Wizards forward Marvin Bagley III (35) in the second half at Little Caesars Arena. Mandatory Credit: Rick Osentoski-Imagn Images
Rick Osentoski-Imagn Images

Chicago Bulls vs Detroit Pistons Prediction 11/12/2025 Today’s NBA Picks

Pick details

MATCHUP Bulls Chicago Pistons Detroit
Team Records 6-4 9-2
Spread +2.5 -110 -2.5 -110
Moneyline +114 -135
Total Over 234.5 (-108) Under 234.5 (-112)
Where Little Caesars Arena, Detroit, MI
When Wednesday, November 12, 2025
Time 07:00 PM EST
TV CHSN

The Chicago Bulls invade Little Caesars Arena to battle the Detroit Pistons on Wednesday night. Here’s a Chicago Bulls vs Detroit Pistons Prediction. This article will include a Chicago Bulls vs Detroit Pistons Pick.

Chicago Bulls Betting Preview 

The Chicago Bulls have cooled off lately as they’ve lost four of their last five games and they will be hoping to avoid a fourth straight defeat after getting stopped by the Spurs in a 121-117 defeat on Monday. Kevin Huerter led the team with 23 points and five assists on eight of 14 shooting, Tre Jones and Ayo Dosunmu each scored 20 points while Matas Buzelis chipped in with 15 points. As a team, the Bulls shot 44 percent from the field and 16 of 38 from the 3-point line as they poured in 38 points in the second quarter to control most of the contest. But even with a five-point lead late in the fourth quarter, the Bulls couldn’t defeat the Spurs who closed the final 1:32 on a 12-3 run to snatch the game away. 

Detroit Pistons Betting Preview 

Meanwhile, the Detroit Pistons have been on fire as they’ve won nine of their first 11 games and they will be eager to build on their current seven-game win streak after outlasting the Wizards in a 137-135 home win on Monday. Cade Cunningham led the team with a triple-double of 46 points with 12 rebounds, 11 assists and five steals, Daniss Jenkins added 24 points off the bench while Jalen Duren chipped in with 19 points and 14 rebounds. As a team, the Pistons shot just 41 percent from the field and 13 of 41 from the 3-point line as they exploded for 40 points in the fourth quarter to tie the game after trailing by 13 points. Before they went on a crucial 7-1 run in overtime to escape with the narrow win at home. 

Why the Detroit Pistons will win

  • The Bulls have lost each of their last seven road games against Eastern Conference opponents that held a winning record.
  • The Pistons have won nine of their last 10 games.
  • The Bulls have failed to cover the spread in each of their last seven Wednesday road games.
  • The Pistons have covered the spread in eight of their last 10 night games against Bulls teams that held a winning record.

Why the Chicago Bulls will win

  • The Pistons have lost 29 of their last 30 night games against Central Division opponents that held a winning record.
  • The Bulls have won each of their last six games at Little Caesars Arena following a loss.
  • The Bulls have covered the spread in each of their last six road games against Central Division opponents following a loss.
  • The Pistons have failed to cover the spread in each of their last five home games against teams that held a winning record.

Total Points Facts

  • Nine of the Bulls’ last 11 games as road underdogs have gone OVER the total points line.
  • Four of the Pistons’ last five home games against the Bulls have gone OVER the total points line.

Chicago Bulls vs Detroit Pistons Prediction

The Bulls have ruled out Coby White again and they are keeping an eye on Josh Giddey who is questionable with an ankle injury. The Pistons have ruled out Isaiah Stewart and Ausar Thompson, with Cade Cunningham listed as questionable for this one. This is definitely one of those games where you want to check the lineups before tipoff given the injury cloud hanging over both teams. With that being said, the Bulls were almost good enough to take down the red-hot Spurs in their last outing without Giddey. I think they can go one better against this Pistons team who rely heavily on Cunningham, who could be sitting this one out.

Peter Tran's Pick: Chicago +1.5

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