Oct 24, 2025; New Orleans, Louisiana, USA;  New Orleans Pelicans forward Zion Williamson (1) reacts to a play against the San Antonio Spurs during the second half at Smoothie King Center. Mandatory Credit: Stephen Lew-Imagn Images
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Boston Celtics vs New Orleans Pelicans Prediction 10/27/2025 Today’s NBA Picks

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Boston (0-3) vs New Orleans (0-2)

October 27, 2025 at 08:00 PM EDT

The Line: Betting Odds: New Orleans -2 — Over/Under: +232.5

(Get latest betting odds)

The Boston Celtics and the New Orleans Pelicans duke it out at the Smoothie King Center on Monday night. Here’s a Boston Celtics vs New Orleans Pelicans Prediction. This article will include a Boston Celtics vs New Orleans Pelicans Pick.

Boston Celtics Betting Preview 

The Boston Celtics are still searching for their first win of the season after coming up just short to the Pistons in a 119-113 road defeat last night. Jaylen Brown led the team with a season-high 41 points, six rebounds, and four assists on 12 of 25 shooting. Payton Pritchard added 21 points with 10 rebounds and four assists on eight of 16 shooting, while Derrick White chipped in with 15 points, three assists, and four steals on six of 18 shooting.

As a team, the Celtics shot just 42 percent from the field and 15 of 45 from the 3-point line as they stormed out to an early 17-point lead. However, it didn’t last long at all as they were quickly trailing by as many as 15 points before they went on a rally that proved to be all too late in the end. 

New Orleans Pelicans Betting Preview 

Meanwhile, the New Orleans Pelicans have yet to taste victory this season as they are now looking to avoid a third straight defeat after falling just short to the Spurs in a painful 120-116 overtime defeat on Friday night. Zion Williamson led the team with 27 points, 10 rebounds, and seven assists on eight of 18 shooting. Trey Murphy III added 24 points with 10 rebounds and five assists, Jordan Poole scored 21 points with five assists, and Derik Queen chipped in with 15 points off the bench.

As a team, the Pelicans shot 43 percent from the field and 10 of 32 from the 3-point line. They missed on a crucial opportunity to win the game at the end of regulation when Williamson missed a go-ahead free throw with 12.2 seconds on the clock. That came back to bite them in the overtime period where the Spurs opened with a 9-3 run to take the game away from them. 

Why the New Orleans Pelicans will win

  • The favorites have won each of the Pelicans’ last nine games at Smoothie King Center.
  • The Celtics have lost each of their last four road games.
  • The Celtics have failed to cover the spread in each of their last four road games.
  • The Pelicans have covered the spread in each of their last four games as home favorites.
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Why the Boston Celtics will win

  • The Celtics have won each of their last 10 games against Western Conference opponents that held a losing record.
  • The Pelicans have lost each of their last nine games.
  • The Celtics have covered the spread in each of their last six night games against the Pelicans following a road loss.
  • The Pelicans have failed to cover the spread in nine of their last 10 games after coming off overtime.

Total Points Facts

  • Eight of the Celtics’ last nine games as road underdogs have gone UNDER the total points line.
  • Each of the Pelicans’ last four games as home favorites have gone UNDER the total points line.

Boston Celtics vs New Orleans Pelicans Prediction

The Celtics are still shorthanded with Jayson Tatum still ruled out, while the Pelicans have ruled out Dejounte Murray, and they are keeping eyes on Karlo Matkovic, Yves Missi and Kevon Looney who are all questionable. The Celtics will be disappointed that they haven’t been able to win any of their first three games. They might still be kicking themselves after blowing a 17-point lead in last night’s defeat to the Pistons, while the Pelicans’ last game was an overtime loss to the Spurs back on Friday.

The Celtics beat the Pelicans in both meetings last season, and they are currently on an eight-game win streak between the teams, but it’s the Pelicans who open as the slight favorites. I think it’s justified given home court advantage and the extra rest they have had. The Celtics have a chance if Brown can have another big game, but I prefer a play on the more balanced Pelicans squad to earn their first win of the season.

Peter Tran's Pick: New Orleans -2

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